CMTR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006370Biological process7-methylguanosine mRNA capping
GO_0006397Biological processmRNA processing
GO_0032259Biological processmethylation
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004483Molecular functionmRNA (nucleoside-2'-O-)-methyltransferase activity
GO_0003676Molecular functionnucleic acid binding

IV. Literature review

[source]
Gene nameCMTR1
Protein nameCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95)
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap1 2'O-ribose methyltransferase 1)
SynonymsMTR1
KIAA0082
FTSJD2
DescriptionFUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. .

FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1). .

FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1). .

FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1). .

AccessionsENST00000373451.9
Q5T7F5
ENST00000475364.1
ENST00000457419.1
H0YCQ1
Q8N1G2
ENST00000455891.5
H0Y4T0