Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 14 studies | 30% ± 13% | |
B cell | 13 studies | 20% ± 5% | |
astrocyte | 12 studies | 36% ± 19% | |
microglial cell | 12 studies | 31% ± 13% | |
glutamatergic neuron | 11 studies | 43% ± 27% | |
oligodendrocyte precursor cell | 11 studies | 35% ± 15% | |
oligodendrocyte | 11 studies | 30% ± 14% | |
GABAergic neuron | 9 studies | 47% ± 23% | |
macrophage | 8 studies | 31% ± 10% | |
fibroblast | 7 studies | 24% ± 6% | |
epithelial cell | 6 studies | 27% ± 16% | |
interneuron | 6 studies | 51% ± 24% | |
adipocyte | 6 studies | 22% ± 5% | |
neuron | 5 studies | 44% ± 18% | |
plasma cell | 5 studies | 29% ± 7% | |
myeloid cell | 5 studies | 24% ± 7% | |
endothelial cell of lymphatic vessel | 5 studies | 26% ± 8% | |
monocyte | 5 studies | 26% ± 6% | |
pericyte | 5 studies | 22% ± 9% | |
smooth muscle cell | 5 studies | 19% ± 3% | |
granule cell | 4 studies | 28% ± 3% | |
precursor B cell | 4 studies | 38% ± 11% | |
immature B cell | 4 studies | 41% ± 14% | |
dendritic cell | 4 studies | 20% ± 3% | |
mast cell | 4 studies | 19% ± 3% | |
retinal cone cell | 4 studies | 38% ± 15% | |
retinal rod cell | 4 studies | 36% ± 9% | |
T cell | 4 studies | 23% ± 6% | |
club cell | 4 studies | 24% ± 9% | |
naive B cell | 4 studies | 23% ± 8% | |
GABAergic interneuron | 3 studies | 37% ± 4% | |
progenitor cell | 3 studies | 28% ± 2% | |
CD4-positive, alpha-beta T cell | 3 studies | 20% ± 0% | |
hepatocyte | 3 studies | 40% ± 19% | |
ependymal cell | 3 studies | 37% ± 7% | |
alveolar macrophage | 3 studies | 29% ± 10% | |
ciliated cell | 3 studies | 21% ± 7% | |
natural killer cell | 3 studies | 24% ± 3% | |
type I pneumocyte | 3 studies | 24% ± 6% | |
type II pneumocyte | 3 studies | 23% ± 6% | |
lymphocyte | 3 studies | 35% ± 10% | |
basal cell | 3 studies | 35% ± 22% | |
memory B cell | 3 studies | 19% ± 3% | |
abnormal cell | 3 studies | 29% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 983.05 | 1445 / 1445 | 100% | 17.69 | 183 / 183 |
lung | 100% | 908.53 | 578 / 578 | 100% | 14.57 | 1155 / 1155 |
brain | 100% | 985.50 | 2635 / 2642 | 100% | 15.07 | 705 / 705 |
uterus | 100% | 1127.09 | 170 / 170 | 100% | 15.20 | 457 / 459 |
breast | 100% | 955.00 | 459 / 459 | 99% | 15.77 | 1112 / 1118 |
thymus | 100% | 836.46 | 653 / 653 | 99% | 12.44 | 600 / 605 |
prostate | 100% | 866.88 | 245 / 245 | 99% | 11.74 | 496 / 502 |
bladder | 100% | 1058.10 | 21 / 21 | 98% | 12.22 | 496 / 504 |
stomach | 100% | 623.75 | 358 / 359 | 98% | 12.89 | 280 / 286 |
adrenal gland | 100% | 1082.83 | 258 / 258 | 97% | 15.34 | 224 / 230 |
intestine | 100% | 921.02 | 966 / 966 | 97% | 12.56 | 512 / 527 |
kidney | 100% | 648.67 | 89 / 89 | 96% | 10.72 | 869 / 901 |
ovary | 100% | 861.56 | 180 / 180 | 96% | 8.48 | 412 / 430 |
skin | 100% | 1190.53 | 1808 / 1809 | 95% | 15.64 | 449 / 472 |
pancreas | 94% | 339.48 | 309 / 328 | 99% | 10.09 | 176 / 178 |
liver | 100% | 635.62 | 226 / 226 | 91% | 7.30 | 371 / 406 |
adipose | 100% | 957.75 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1253.50 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 40.50 | 29 / 29 |
spleen | 100% | 1518.02 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 16.23 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.03 | 1 / 1 |
muscle | 100% | 675.94 | 801 / 803 | 0% | 0 | 0 / 0 |
heart | 96% | 640.52 | 825 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 93% | 1307.57 | 860 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 75% | 6.06 | 60 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006370 | Biological process | 7-methylguanosine mRNA capping |
GO_0006396 | Biological process | RNA processing |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005525 | Molecular function | GTP binding |
GO_0004484 | Molecular function | mRNA guanylyltransferase activity |
GO_0050355 | Molecular function | inorganic triphosphate phosphatase activity |
GO_0140818 | Molecular function | mRNA 5'-triphosphate monophosphatase activity |
GO_0008192 | Molecular function | RNA guanylyltransferase activity |
GO_0004721 | Molecular function | phosphoprotein phosphatase activity |
GO_0005515 | Molecular function | protein binding |
GO_0004651 | Molecular function | polynucleotide 5'-phosphatase activity |
GO_0005524 | Molecular function | ATP binding |
Gene name | RNGTT |
Protein name | mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] |
Synonyms | CAP1A |
Description | FUNCTION: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate. . |
Accessions | ENST00000538899.2 [O60942-3] ENST00000369475.7 [O60942-2] O60942 ENST00000369485.9 [O60942-1] |