RNGTT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006370Biological process7-methylguanosine mRNA capping
GO_0006396Biological processRNA processing
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0004484Molecular functionmRNA guanylyltransferase activity
GO_0050355Molecular functioninorganic triphosphate phosphatase activity
GO_0140818Molecular functionmRNA 5'-triphosphate monophosphatase activity
GO_0008192Molecular functionRNA guanylyltransferase activity
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0004651Molecular functionpolynucleotide 5'-phosphatase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameRNGTT
Protein namemRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)]
SynonymsCAP1A
DescriptionFUNCTION: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate. .

AccessionsENST00000538899.2 [O60942-3]
ENST00000369475.7 [O60942-2]
O60942
ENST00000369485.9 [O60942-1]