NCBP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006406Biological processmRNA export from nucleus
GO_0051607Biological processdefense response to virus
GO_0006408Biological processsnRNA export from nucleus
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0006370Biological process7-methylguanosine mRNA capping
GO_0035194Biological processregulatory ncRNA-mediated post-transcriptional gene silencing
GO_0005846Cellular componentnuclear cap binding complex
GO_0016607Cellular componentnuclear speck
GO_0034518Cellular componentRNA cap binding complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0000339Molecular functionRNA cap binding
GO_0000340Molecular functionRNA 7-methylguanosine cap binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNCBP3
Protein nameNuclear cap-binding protein subunit 3
Nuclear cap binding subunit 3
Nuclear cap-binding protein subunit 3 (Protein ELG)
SynonymsC17orf85
DescriptionFUNCTION: Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth . .

AccessionsQ53F19
ENST00000389005.6 [Q53F19-1]
ENST00000574911.5
K7EQA5
K7ELP6
L0R6D6
ENST00000576523.1