RNF167 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	27 studies	28% ± 10%	Explore
CD8-positive, alpha-beta T cell	25 studies	30% ± 10%	Explore
CD4-positive, alpha-beta T cell	22 studies	24% ± 8%	Explore
T cell	19 studies	26% ± 8%	Explore
regulatory T cell	19 studies	29% ± 8%	Explore
mature NK T cell	15 studies	29% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	32% ± 11%	Explore
B cell	12 studies	21% ± 4%	Explore
gamma-delta T cell	12 studies	31% ± 9%	Explore
naive B cell	12 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	27% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	26% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	31% ± 11%	Explore
non-classical monocyte	9 studies	23% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	22% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	26% ± 5%	Explore
mucosal invariant T cell	9 studies	27% ± 6%	Explore
memory B cell	9 studies	21% ± 4%	Explore
ciliated cell	8 studies	30% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	29% ± 11%	Explore
endothelial cell	7 studies	26% ± 8%	Explore
fibroblast	7 studies	26% ± 8%	Explore
epithelial cell	7 studies	35% ± 17%	Explore
T follicular helper cell	7 studies	23% ± 4%	Explore
plasmacytoid dendritic cell	7 studies	24% ± 6%	Explore
basal cell	6 studies	30% ± 14%	Explore
classical monocyte	6 studies	23% ± 4%	Explore
exhausted T cell	5 studies	40% ± 5%	Explore
pericyte	5 studies	20% ± 3%	Explore
smooth muscle cell	5 studies	22% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	42% ± 10%	Explore
hematopoietic precursor cell	4 studies	20% ± 4%	Explore
conventional dendritic cell	4 studies	29% ± 9%	Explore
myofibroblast cell	4 studies	22% ± 4%	Explore
type I pneumocyte	4 studies	26% ± 7%	Explore
abnormal cell	4 studies	29% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	38% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	30% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	33% ± 10%	Explore
plasmablast	3 studies	45% ± 14%	Explore
secretory cell	3 studies	21% ± 5%	Explore
myeloid cell	3 studies	19% ± 2%	Explore
plasma cell	3 studies	28% ± 9%	Explore
immature B cell	3 studies	21% ± 5%	Explore
type II pneumocyte	3 studies	26% ± 12%	Explore
intraepithelial lymphocyte	3 studies	24% ± 11%	Explore
macrophage	3 studies	21% ± 3%	Explore
dendritic cell	3 studies	29% ± 10%	Explore
enteroendocrine cell	3 studies	24% ± 9%	Explore
goblet cell	3 studies	23% ± 7%	Explore
T-helper 1 cell	3 studies	25% ± 5%	Explore
T-helper 17 cell	3 studies	23% ± 1%	Explore
hematopoietic stem cell	3 studies	21% ± 1%	Explore
double negative thymocyte	3 studies	37% ± 5%	Explore
neuron	3 studies	26% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	23% ± 4%	Explore
lung	7 studies	23% ± 6%	Explore
lymph node	4 studies	20% ± 2%	Explore
bone marrow	3 studies	21% ± 5%	Explore
brain	3 studies	22% ± 2%	Explore
intestine	3 studies	23% ± 9%	Explore
liver	3 studies	27% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6265.12	1445 / 1445	100%	92.36	183 / 183
ovary	100%	4660.85	180 / 180	100%	156.47	430 / 430
pancreas	100%	3254.88	328 / 328	100%	99.98	178 / 178
prostate	100%	5456.30	245 / 245	100%	147.44	502 / 502
thymus	100%	5757.27	653 / 653	100%	160.12	605 / 605
brain	100%	4614.59	2640 / 2642	100%	147.11	705 / 705
intestine	100%	6118.30	966 / 966	100%	102.53	526 / 527
skin	100%	5967.12	1809 / 1809	100%	141.81	471 / 472
uterus	100%	5799.39	170 / 170	100%	131.50	458 / 459
liver	100%	4949.38	226 / 226	100%	99.57	405 / 406
lung	100%	4754.61	578 / 578	100%	110.71	1151 / 1155
kidney	100%	5051.58	89 / 89	100%	127.15	897 / 901
breast	100%	4500.16	459 / 459	100%	140.75	1113 / 1118
adrenal gland	100%	5707.48	258 / 258	99%	102.46	228 / 230
bladder	100%	6129.38	21 / 21	99%	118.14	499 / 504
stomach	100%	4787.20	359 / 359	99%	99.64	283 / 286
adipose	100%	4179.69	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	140.76	80 / 80
lymph node	0%	0	0 / 0	100%	116.83	29 / 29
muscle	100%	5225.18	803 / 803	0%	0	0 / 0
spleen	100%	6600.95	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	130.50	45 / 45
ureter	0%	0	0 / 0	100%	54.88	1 / 1
blood vessel	100%	4398.13	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	9397.77	926 / 929	0%	0	0 / 0
heart	99%	3846.57	854 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045786	Biological process	negative regulation of cell cycle
GO_0000209	Biological process	protein polyubiquitination
GO_1990253	Biological process	cellular response to leucine starvation
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0051966	Biological process	regulation of synaptic transmission, glutamatergic
GO_0051640	Biological process	organelle localization
GO_0032418	Biological process	lysosome localization
GO_0070534	Biological process	protein K63-linked ubiquitination
GO_0035519	Biological process	protein K29-linked ubiquitination
GO_1904263	Biological process	positive regulation of TORC1 signaling
GO_1904262	Biological process	negative regulation of TORC1 signaling
GO_0005886	Cellular component	plasma membrane
GO_0005764	Cellular component	lysosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005768	Cellular component	endosome
GO_0005765	Cellular component	lysosomal membrane
GO_0036020	Cellular component	endolysosome membrane
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0008270	Molecular function	zinc ion binding
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RNF167
Protein name	RING-type E3 ubiquitin transferase (EC 2.3.2.27) Ring finger protein 167 E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167)
Synonyms	LP2254 RING105
Description	FUNCTION: E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway . Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 . Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex . Also involved in protein trafficking and localization . Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 . Does not catalyze ubiquitination of GluA1/GRIA1 . Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 . Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B . Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 . Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N . .
Accessions	ENST00000262482.11 [Q9H6Y7-1] I3L0V7 ENST00000573404.5 ENST00000575400.5 ENST00000575111.5 [Q9H6Y7-1] ENST00000570328.5 I3L2D4 K7EN24 ENST00000576452.5 I3L1K4 I3L2Y3 ENST00000576229.5 [Q9H6Y7-2] ENST00000576965.1 ENST00000572430.5 [Q9H6Y7-1] Q9H6Y7 I3L462 ENST00000571816.5 [Q9H6Y7-1] ENST00000572382.5

RNF167 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review