RNASEK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
classical monocyte	21 studies	52% ± 29%	Explore
natural killer cell	19 studies	39% ± 20%	Explore
non-classical monocyte	18 studies	61% ± 28%	Explore
regulatory T cell	17 studies	46% ± 24%	Explore
macrophage	16 studies	53% ± 26%	Explore
B cell	15 studies	44% ± 18%	Explore
conventional dendritic cell	15 studies	53% ± 30%	Explore
CD8-positive, alpha-beta T cell	14 studies	49% ± 23%	Explore
plasmacytoid dendritic cell	12 studies	61% ± 28%	Explore
endothelial cell	11 studies	33% ± 20%	Explore
naive B cell	11 studies	40% ± 18%	Explore
CD4-positive, alpha-beta T cell	11 studies	48% ± 24%	Explore
pericyte	11 studies	45% ± 18%	Explore
memory B cell	10 studies	48% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	41% ± 22%	Explore
fibroblast	10 studies	42% ± 21%	Explore
T cell	9 studies	32% ± 15%	Explore
gamma-delta T cell	9 studies	40% ± 17%	Explore
mature NK T cell	9 studies	48% ± 10%	Explore
mucosal invariant T cell	9 studies	48% ± 14%	Explore
endothelial cell of lymphatic vessel	8 studies	40% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	35% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	50% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	48% ± 24%	Explore
dendritic cell	8 studies	59% ± 26%	Explore
mast cell	8 studies	44% ± 23%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	41% ± 12%	Explore
plasma cell	7 studies	57% ± 16%	Explore
monocyte	6 studies	44% ± 30%	Explore
myeloid cell	6 studies	38% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	51% ± 27%	Explore
smooth muscle cell	6 studies	50% ± 10%	Explore
secretory cell	6 studies	44% ± 20%	Explore
plasmablast	5 studies	71% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	63% ± 15%	Explore
epithelial cell	5 studies	25% ± 11%	Explore
basal cell	5 studies	23% ± 10%	Explore
CD4-positive helper T cell	4 studies	42% ± 20%	Explore
innate lymphoid cell	4 studies	30% ± 10%	Explore
neutrophil	4 studies	37% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	66% ± 22%	Explore
platelet	4 studies	34% ± 9%	Explore
alveolar macrophage	4 studies	48% ± 31%	Explore
endothelial cell of artery	4 studies	38% ± 19%	Explore
ciliated cell	4 studies	51% ± 26%	Explore
T follicular helper cell	4 studies	42% ± 17%	Explore
vein endothelial cell	4 studies	30% ± 20%	Explore
erythrocyte	4 studies	29% ± 14%	Explore
immature B cell	4 studies	36% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	41% ± 14%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	60% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	41% ± 12%	Explore
hematopoietic precursor cell	3 studies	34% ± 16%	Explore
leukocyte	3 studies	45% ± 20%	Explore
common myeloid progenitor	3 studies	56% ± 28%	Explore
hematopoietic stem cell	3 studies	72% ± 8%	Explore
precursor B cell	3 studies	34% ± 16%	Explore
pro-B cell	3 studies	35% ± 21%	Explore
exhausted T cell	3 studies	55% ± 29%	Explore
intermediate monocyte	3 studies	45% ± 21%	Explore
capillary endothelial cell	3 studies	31% ± 18%	Explore
endothelial cell of vascular tree	3 studies	56% ± 5%	Explore
microglial cell	3 studies	27% ± 12%	Explore
abnormal cell	3 studies	42% ± 14%	Explore
oligodendrocyte precursor cell	3 studies	31% ± 21%	Explore
interneuron	3 studies	25% ± 10%	Explore
connective tissue cell	3 studies	32% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	60% ± 22%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	45% ± 18%	Explore
uterus	3 studies	43% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	5095.28	180 / 180	94%	2.29	404 / 430
esophagus	100%	4958.88	1445 / 1445	93%	2.11	171 / 183
bladder	100%	4858.62	21 / 21	93%	2.54	467 / 504
brain	100%	6213.24	2639 / 2642	93%	2.47	654 / 705
stomach	100%	4434.75	359 / 359	91%	1.93	261 / 286
pancreas	100%	2653.24	328 / 328	90%	2.41	161 / 178
skin	100%	5910.51	1808 / 1809	89%	2.21	421 / 472
thymus	100%	5833.37	653 / 653	88%	2.09	532 / 605
uterus	100%	5223.25	170 / 170	87%	1.94	401 / 459
lung	100%	7571.29	577 / 578	86%	2.10	994 / 1155
intestine	100%	5261.25	966 / 966	85%	2.08	446 / 527
kidney	100%	9259.09	89 / 89	84%	2.55	754 / 901
adrenal gland	100%	11815.96	258 / 258	78%	1.49	179 / 230
prostate	100%	5562.32	245 / 245	76%	1.48	382 / 502
breast	100%	5922.90	459 / 459	69%	1.34	770 / 1118
liver	100%	3246.54	226 / 226	52%	1.07	210 / 406
adipose	100%	6204.80	1204 / 1204	0%	0	0 / 0
peripheral blood	100%	12597.57	929 / 929	0%	0	0 / 0
spleen	100%	8544.87	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	1.57	1 / 1
blood vessel	100%	6484.65	1334 / 1335	0%	0	0 / 0
muscle	99%	3663.81	796 / 803	0%	0	0 / 0
heart	99%	4267.74	849 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	3.38	27 / 29
eye	0%	0	0 / 0	93%	2.15	74 / 80
tonsil	0%	0	0 / 0	80%	1.62	36 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007035	Biological process	vacuolar acidification
GO_1902600	Biological process	proton transmembrane transport
GO_0061795	Biological process	Golgi lumen acidification
GO_0019065	Biological process	receptor-mediated endocytosis of virus by host cell
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0007042	Biological process	lysosomal lumen acidification
GO_0048388	Biological process	endosomal lumen acidification
GO_0051452	Biological process	intracellular pH reduction
GO_0000220	Cellular component	vacuolar proton-transporting V-type ATPase, V0 domain
GO_0010008	Cellular component	endosome membrane
GO_0000139	Cellular component	Golgi membrane
GO_0005886	Cellular component	plasma membrane
GO_0030665	Cellular component	clathrin-coated vesicle membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0033176	Cellular component	proton-transporting V-type ATPase complex
GO_0016020	Cellular component	membrane
GO_0004521	Molecular function	RNA endonuclease activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RNASEK
Protein name	Ribonuclease kappa isoform 4 Ribonuclease K Ribonuclease kappa isoform 8 (Ribonuclease kappa isoform 9) Ribonuclease kappa isoform 7 Ribonuclease kappa (RNase K) (RNase kappa) (EC 3.1.-.-) (V-type proton ATPase subunit f) (V-ATPase subunit f) Ribonuclease kappa isoform 8 Ribonuclease kappa isoform 5 Ribonuclease kappa isoform 6 (Ribonuclease kappa isoform 7) Ribonuclease kappa isoform 9
Synonyms
Description	FUNCTION: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate . Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments . Required at an early stage of receptor-mediated endocytosis . .; FUNCTION: (Microbial infection) Required at an early stage of both clathrin-mediated and clathrin-independent endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, influenza, and human rhinoviruses . .
Accessions	A0A3Q7ZZZ6 H0YIU3 A0A1L2BPI1 ENST00000549393.2 H0YIM4 ENST00000552842.1 A0A1L2BPI6 ENST00000593646.6 Q6P5S7 ENST00000552321.2 A0A3S6CYT1 A0A3Q7ZYN9 F8W1G5 A0A087WSZ8 ENST00000548577.5 [Q6P5S7-1] ENST00000552039.2 A0A0C4DH85 A0A1L2BPJ0 A0A0C4DH89 ENST00000570898.1 ENST00000546395.5 A0A3S7I545

RNASEK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review