RBCK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0000209Biological processprotein polyubiquitination
GO_0050852Biological processT cell receptor signaling pathway
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0060546Biological processnegative regulation of necroptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0042742Biological processdefense response to bacterium
GO_0009893Biological processpositive regulation of metabolic process
GO_0097039Biological processprotein linear polyubiquitination
GO_0071797Cellular componentLUBAC complex
GO_0005829Cellular componentcytosol
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_1990757Molecular functionubiquitin ligase activator activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameRBCK1
Protein nameHCG2019817, isoform CRA_d (RANBP2-type and C3HC4-type zinc finger containing 1)
RANBP2-type and C3HC4-type zinc finger containing 1
RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31)
RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3)
RANBP2-type and C3HC4-type zinc finger containing 1 (cDNA FLJ60704, highly similar to RanBP-type and C3HC4-type zincfinger-containing protein 1)
SynonymshCG_2019817
UBCE7IP3
XAP3
XAP4
C20orf18
RNF54
DescriptionFUNCTION: E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates . Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination . Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome . Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation . LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways . Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation . LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex . The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria . LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin . The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation . Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis . Binds polyubiquitin of different linkage types . .

AccessionsENST00000441733.5
ENST00000411647.5
A0A8V8TLQ1
ENST00000400245.3
A6PVJ6
ENST00000475269.5
A0A8V8TMQ4
Q5JWR1
ENST00000400247.3
ENST00000415942.5
ENST00000697804.1
ENST00000697805.1
A0A8V8TMZ2
Q9BYM8
ENST00000353660.7 [Q9BYM8-3]
A6PVJ7
H0Y4S7
A6PVJ5
ENST00000382214.7
B4DML5
G3XAG9
ENST00000414880.1
ENST00000382181.2 [Q9BYM8-4]
ENST00000356286.10 [Q9BYM8-1]