RANBP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	27 studies	26% ± 11%	Explore
endothelial cell	23 studies	27% ± 11%	Explore
classical monocyte	16 studies	22% ± 4%	Explore
CD4-positive, alpha-beta T cell	16 studies	19% ± 3%	Explore
B cell	15 studies	21% ± 5%	Explore
natural killer cell	15 studies	20% ± 3%	Explore
fibroblast	14 studies	21% ± 7%	Explore
plasmacytoid dendritic cell	14 studies	31% ± 10%	Explore
CD8-positive, alpha-beta T cell	14 studies	21% ± 3%	Explore
mast cell	13 studies	26% ± 8%	Explore
smooth muscle cell	13 studies	20% ± 2%	Explore
conventional dendritic cell	13 studies	22% ± 8%	Explore
memory B cell	12 studies	20% ± 4%	Explore
regulatory T cell	12 studies	21% ± 4%	Explore
microglial cell	11 studies	31% ± 10%	Explore
mucosal invariant T cell	11 studies	20% ± 4%	Explore
astrocyte	11 studies	27% ± 11%	Explore
T cell	10 studies	24% ± 12%	Explore
dendritic cell	10 studies	26% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	21% ± 4%	Explore
gamma-delta T cell	10 studies	27% ± 11%	Explore
monocyte	9 studies	25% ± 7%	Explore
pericyte	9 studies	26% ± 10%	Explore
ciliated cell	9 studies	28% ± 13%	Explore
epithelial cell	9 studies	36% ± 23%	Explore
naive B cell	9 studies	20% ± 4%	Explore
glutamatergic neuron	9 studies	45% ± 27%	Explore
oligodendrocyte	9 studies	27% ± 9%	Explore
endothelial cell of lymphatic vessel	8 studies	24% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	19% ± 2%	Explore
non-classical monocyte	8 studies	20% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	22% ± 6%	Explore
myeloid cell	8 studies	30% ± 13%	Explore
mature NK T cell	8 studies	21% ± 5%	Explore
basal cell	7 studies	26% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	19% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	19% ± 5%	Explore
GABAergic neuron	7 studies	42% ± 23%	Explore
type I pneumocyte	6 studies	21% ± 5%	Explore
type II pneumocyte	6 studies	20% ± 4%	Explore
leukocyte	6 studies	26% ± 3%	Explore
neuron	6 studies	35% ± 15%	Explore
goblet cell	6 studies	33% ± 19%	Explore
club cell	5 studies	23% ± 7%	Explore
retinal cone cell	5 studies	28% ± 7%	Explore
T follicular helper cell	5 studies	21% ± 6%	Explore
innate lymphoid cell	5 studies	21% ± 7%	Explore
oligodendrocyte precursor cell	5 studies	30% ± 10%	Explore
alveolar macrophage	5 studies	23% ± 9%	Explore
hematopoietic precursor cell	4 studies	25% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 2%	Explore
mononuclear phagocyte	4 studies	22% ± 4%	Explore
hematopoietic stem cell	4 studies	20% ± 6%	Explore
adipocyte	4 studies	22% ± 5%	Explore
lymphocyte	4 studies	31% ± 13%	Explore
respiratory goblet cell	4 studies	25% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 4%	Explore
connective tissue cell	4 studies	20% ± 4%	Explore
interneuron	4 studies	48% ± 22%	Explore
plasma cell	3 studies	25% ± 11%	Explore
ionocyte	3 studies	26% ± 4%	Explore
secretory cell	3 studies	20% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	21% ± 6%	Explore
plasmablast	3 studies	29% ± 14%	Explore
GABAergic interneuron	3 studies	20% ± 1%	Explore
retinal ganglion cell	3 studies	29% ± 5%	Explore
cardiac muscle cell	3 studies	15% ± 0%	Explore
endothelial cell of artery	3 studies	16% ± 0%	Explore
OFF-bipolar cell	3 studies	29% ± 9%	Explore
retina horizontal cell	3 studies	22% ± 8%	Explore
rod bipolar cell	3 studies	24% ± 6%	Explore
capillary endothelial cell	3 studies	18% ± 1%	Explore
hepatocyte	3 studies	31% ± 20%	Explore
granulocyte	3 studies	23% ± 5%	Explore
neutrophil	3 studies	18% ± 2%	Explore
enteroendocrine cell	3 studies	31% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 10%	Explore
vein endothelial cell	3 studies	29% ± 16%	Explore
granule cell	3 studies	22% ± 3%	Explore
renal principal cell	3 studies	26% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	32% ± 20%	Explore
peripheral blood	10 studies	19% ± 2%	Explore
lung	6 studies	24% ± 5%	Explore
eye	4 studies	27% ± 12%	Explore
kidney	4 studies	20% ± 1%	Explore
liver	4 studies	26% ± 12%	Explore
uterus	3 studies	27% ± 11%	Explore
adipose	3 studies	20% ± 3%	Explore
lymph node	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	7226.98	1445 / 1445	100%	49.21	183 / 183
prostate	100%	8858.17	245 / 245	100%	61.77	502 / 502
breast	100%	7156.42	459 / 459	100%	46.39	1116 / 1118
lung	100%	7740.44	578 / 578	100%	32.31	1152 / 1155
pancreas	100%	5491.38	328 / 328	99%	29.57	177 / 178
thymus	100%	8579.57	653 / 653	99%	37.53	600 / 605
uterus	100%	8058.29	170 / 170	99%	29.64	455 / 459
brain	99%	4908.92	2612 / 2642	100%	27.70	704 / 705
bladder	100%	6919.62	21 / 21	99%	26.06	497 / 504
stomach	100%	6979.16	359 / 359	98%	32.84	280 / 286
intestine	100%	7367.23	966 / 966	97%	32.32	512 / 527
kidney	100%	4983.03	89 / 89	97%	24.08	870 / 901
adrenal gland	100%	11031.03	258 / 258	97%	33.59	222 / 230
ovary	100%	12378.07	180 / 180	96%	16.36	414 / 430
skin	100%	8055.83	1808 / 1809	95%	33.52	449 / 472
liver	100%	3865.10	226 / 226	89%	13.42	361 / 406
blood vessel	100%	8597.04	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	30.96	29 / 29
muscle	100%	9281.29	803 / 803	0%	0	0 / 0
spleen	100%	6413.66	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.08	45 / 45
ureter	0%	0	0 / 0	100%	7.89	1 / 1
adipose	100%	7384.31	1203 / 1204	0%	0	0 / 0
heart	97%	5180.02	832 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	86%	16.31	69 / 80
peripheral blood	82%	3955.36	762 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016925	Biological process	protein sumoylation
GO_0051028	Biological process	mRNA transport
GO_0051642	Biological process	centrosome localization
GO_0051168	Biological process	nuclear export
GO_0006111	Biological process	regulation of gluconeogenesis
GO_0006457	Biological process	protein folding
GO_0006913	Biological process	nucleocytoplasmic transport
GO_0001975	Biological process	response to amphetamine
GO_0006607	Biological process	NLS-bearing protein import into nucleus
GO_0042405	Cellular component	nuclear inclusion body
GO_0106068	Cellular component	SUMO ligase complex
GO_0005643	Cellular component	nuclear pore
GO_0016020	Cellular component	membrane
GO_0005642	Cellular component	annulate lamellae
GO_1990723	Cellular component	cytoplasmic periphery of the nuclear pore complex
GO_0005654	Cellular component	nucleoplasm
GO_0005635	Cellular component	nuclear envelope
GO_0044615	Cellular component	nuclear pore nuclear basket
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0044614	Cellular component	nuclear pore cytoplasmic filaments
GO_0031965	Cellular component	nuclear membrane
GO_0019789	Molecular function	SUMO transferase activity
GO_0003755	Molecular function	peptidyl-prolyl cis-trans isomerase activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0031267	Molecular function	small GTPase binding
GO_0061665	Molecular function	SUMO ligase activity
GO_0005096	Molecular function	GTPase activator activity
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0016018	Molecular function	cyclosporin A binding

IV. Literature review

[source]

Gene name	RANBP2
Protein name	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) RAN binding protein 2 peptidylprolyl isomerase (EC 5.2.1.8)
Synonyms	NUP358
Description	FUNCTION: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I . Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates . Binds single-stranded RNA (in vitro) . May bind DNA . Component of the nuclear export pathway . Specific docking site for the nuclear export factor exportin-1 . Inhibits EIF4E-dependent mRNA export . Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB . Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle . Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity . .
Accessions	ENST00000283195.11 P49792 ENST00000425282.4 ENST00000697740.1 ENST00000697737.1 A0A8V8TLN4 F8WBP7 A0A8V8TMX6 A0A8V8TLA0 ENST00000697747.1 ENST00000697744.1 ENST00000697745.1 A0A8V8TL79 A0A8V8TMN6

RANBP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review