RALBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090141Biological processpositive regulation of mitochondrial fission
GO_0006897Biological processendocytosis
GO_0043547Biological processpositive regulation of GTPase activity
GO_0055085Biological processtransmembrane transport
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_1990961Biological processxenobiotic detoxification by transmembrane export across the plasma membrane
GO_0032489Biological processregulation of Cdc42 protein signal transduction
GO_0006935Biological processchemotaxis
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0043087Biological processregulation of GTPase activity
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_1900753Biological processdoxorubicin transport
GO_0005886Cellular componentplasma membrane
GO_0000922Cellular componentspindle pole
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0008559Molecular functionABC-type xenobiotic transporter activity
GO_0015431Molecular functionABC-type glutathione S-conjugate transporter activity
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0042910Molecular functionxenobiotic transmembrane transporter activity
GO_0005524Molecular functionATP binding
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameRALBP1
Protein nameRALBP1
RalA binding protein 1
RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1)
SynonymsRLIP
RLIP1
RLIP76
DescriptionFUNCTION: Multifunctional protein that functions as a downstream effector of RALA and RALB . As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity . As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis . During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle . During mitosis, also controls mitochondrial fission as an effector of RALA . Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L . .; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. .

AccessionsENST00000383432.8
E7ENF8
ENST00000458039.3
A0A2X0U2N0
ENST00000609094.2
ENST00000019317.8
Q15311
ENST00000585015.6
J3QLT3
A0A1W2PRI7