PUM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035196Biological processmiRNA processing
GO_0007283Biological processspermatogenesis
GO_0043488Biological processregulation of mRNA stability
GO_0008344Biological processadult locomotory behavior
GO_0016441Biological processpost-transcriptional gene silencing
GO_0061157Biological processmRNA destabilization
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0006417Biological processregulation of translation
GO_1900246Biological processpositive regulation of RIG-I signaling pathway
GO_0051983Biological processregulation of chromosome segregation
GO_0048863Biological processstem cell differentiation
GO_0060964Biological processregulation of miRNA-mediated gene silencing
GO_0051726Biological processregulation of cell cycle
GO_2000637Biological processpositive regulation of miRNA-mediated gene silencing
GO_0005654Cellular componentnucleoplasm
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0010494Cellular componentcytoplasmic stress granule
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePUM1
Protein namePumilio homolog 1 (HsPUM) (Pumilio-1)
Pumilio RNA binding family member 1
Pumilio homolog 1
SynonymsKIAA0099
hCG_19946
PUMH1
DescriptionFUNCTION: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) . Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation . Also mediates deadenylation-independent repression by promoting accessibility of miRNAs . Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle . Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation . Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm . Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery . Plays a role in cytoplasmic sensing of viral infection . In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level . .

AccessionsE9PMX1
ENST00000498419.5
ENST00000373741.8
H0YDC5
ENST00000525948.5
ENST00000527498.1
H0YED4
Q5T1Z4
H0YC97
ENST00000257075.9 [Q14671-1]
E9PR38
H0YEH2
H0YDK8
ENST00000529846.5
E9PL65
ENST00000426105.7 [Q14671-3]
ENST00000373747.7
ENST00000530669.1
Q14671
ENST00000440538.6 [Q14671-2]
ENST00000532678.1
Q5T1Z8
ENST00000373742.6 [Q14671-4]
ENST00000525843.5
ENST00000424085.6
ENST00000480602.1
ENST00000531867.1
E9PM68
H0YCK1
ENST00000525997.1
H0YDQ6
ENST00000526215.5