PSMC6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901800Biological processpositive regulation of proteasomal protein catabolic process
GO_0045899Biological processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
GO_0090261Biological processpositive regulation of inclusion body assembly
GO_0036503Biological processERAD pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502Cellular componentproteasome complex
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0016234Cellular componentinclusion body
GO_0005829Cellular componentcytosol
GO_0008540Cellular componentproteasome regulatory particle, base subcomplex
GO_0031597Cellular componentcytosolic proteasome complex
GO_0022624Cellular componentproteasome accessory complex
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0036402Molecular functionproteasome-activating activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePSMC6
Protein nameProteasome 26S subunit, ATPase 6
26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)
SynonymsSUG2
DescriptionFUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. .

AccessionsENST00000553798.5
A0A087X2I1
H0YJT1
H0YJX2
P62333
ENST00000612399.4
H0YJW2
H0YJE9
ENST00000555339.5
H0YJY8
H0YJS8
ENST00000556813.1
H0YJC0
ENST00000554044.5
ENST00000557517.1
ENST00000557240.5
ENST00000553899.5
ENST00000555175.1
ENST00000445930.7
H0YJD2