PSMC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901800Biological processpositive regulation of proteasomal protein catabolic process
GO_0043921Biological processmodulation by host of viral transcription
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000502Cellular componentproteasome complex
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0034774Cellular componentsecretory granule lumen
GO_0000932Cellular componentP-body
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0008540Cellular componentproteasome regulatory particle, base subcomplex
GO_0022624Cellular componentproteasome accessory complex
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0036402Molecular functionproteasome-activating activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene namePSMC3
Protein name26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Proteasome 26S subunit, ATPase 3
SynonymsTBP1
DescriptionFUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. .

AccessionsENST00000531051.6
ENST00000602866.5
E9PMD8
E9PN50
ENST00000530651.5
ENST00000298852.8
ENST00000530887.5
ENST00000530912.5
P17980
ENST00000527906.5
E9PS45
ENST00000619920.4
E9PKD5
E9PMW0
ENST00000526993.1
E9PLG2
E9PM69
ENST00000524447.6
R4GNH3