PSMB4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002862Biological processnegative regulation of inflammatory response to antigenic stimulus
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502Cellular componentproteasome complex
GO_0070062Cellular componentextracellular exosome
GO_0036064Cellular componentciliary basal body
GO_0005839Cellular componentproteasome core complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0019774Cellular componentproteasome core complex, beta-subunit complex
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0001530Molecular functionlipopolysaccharide binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePSMB4
Protein nameProteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)
SynonymsPROS26
DescriptionFUNCTION: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. .

AccessionsP28070
ENST00000290541.7