PSMB10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000902Biological processcell morphogenesis
GO_0042098Biological processT cell proliferation
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0006959Biological processhumoral immune response
GO_0000502Cellular componentproteasome complex
GO_0005839Cellular componentproteasome core complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0019774Cellular componentproteasome core complex, beta-subunit complex
GO_1990111Cellular componentspermatoproteasome complex
GO_0005634Cellular componentnucleus
GO_0004175Molecular functionendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0004298Molecular functionthreonine-type endopeptidase activity

IV. Literature review

[source]
Gene namePSMB10
Protein nameProteasome subunit beta
Proteasome subunit beta type-10 (EC 3.4.25.1) (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i)
proteasome endopeptidase complex (EC 3.4.25.1)
SynonymsMECL1
LMP10
DescriptionFUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

FUNCTION: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. .

AccessionsP40306
Q6IB22
ENST00000574576.2
J3QQN1
ENST00000358514.9