PPP3CC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	24 studies	28% ± 11%	Explore
endothelial cell	23 studies	32% ± 12%	Explore
B cell	22 studies	30% ± 11%	Explore
CD4-positive, alpha-beta T cell	17 studies	21% ± 5%	Explore
memory B cell	15 studies	28% ± 8%	Explore
CD8-positive, alpha-beta T cell	15 studies	26% ± 8%	Explore
regulatory T cell	14 studies	24% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	34% ± 11%	Explore
naive B cell	13 studies	26% ± 6%	Explore
fibroblast	13 studies	24% ± 10%	Explore
mature NK T cell	12 studies	26% ± 9%	Explore
T cell	12 studies	24% ± 8%	Explore
astrocyte	12 studies	34% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	28% ± 8%	Explore
pericyte	10 studies	27% ± 10%	Explore
oligodendrocyte precursor cell	10 studies	34% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	28% ± 10%	Explore
mucosal invariant T cell	9 studies	25% ± 4%	Explore
adipocyte	9 studies	23% ± 5%	Explore
gamma-delta T cell	9 studies	28% ± 9%	Explore
GABAergic neuron	8 studies	38% ± 22%	Explore
glutamatergic neuron	8 studies	41% ± 25%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	24% ± 5%	Explore
plasma cell	7 studies	32% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	29% ± 5%	Explore
microglial cell	7 studies	28% ± 10%	Explore
retinal cone cell	7 studies	45% ± 14%	Explore
smooth muscle cell	7 studies	26% ± 8%	Explore
endothelial cell of lymphatic vessel	7 studies	36% ± 15%	Explore
macrophage	7 studies	28% ± 9%	Explore
retinal rod cell	6 studies	39% ± 19%	Explore
oligodendrocyte	6 studies	27% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	23% ± 5%	Explore
type I pneumocyte	6 studies	26% ± 8%	Explore
plasmablast	5 studies	42% ± 19%	Explore
neuron	5 studies	32% ± 15%	Explore
capillary endothelial cell	5 studies	23% ± 5%	Explore
cardiac muscle cell	5 studies	40% ± 9%	Explore
epithelial cell	5 studies	26% ± 11%	Explore
T follicular helper cell	5 studies	20% ± 5%	Explore
interneuron	5 studies	38% ± 23%	Explore
plasmacytoid dendritic cell	5 studies	20% ± 5%	Explore
pro-B cell	4 studies	36% ± 12%	Explore
immature B cell	4 studies	30% ± 8%	Explore
lymphocyte	4 studies	39% ± 16%	Explore
Mueller cell	4 studies	34% ± 14%	Explore
muscle cell	4 studies	32% ± 15%	Explore
dendritic cell	4 studies	22% ± 5%	Explore
club cell	4 studies	22% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	30% ± 8%	Explore
GABAergic interneuron	3 studies	22% ± 2%	Explore
retinal ganglion cell	3 studies	27% ± 10%	Explore
endothelial cell of artery	3 studies	17% ± 0%	Explore
vein endothelial cell	3 studies	28% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	22% ± 8%	Explore
exhausted T cell	3 studies	21% ± 6%	Explore
myeloid cell	3 studies	24% ± 4%	Explore
endothelial cell of vascular tree	3 studies	38% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	27% ± 1%	Explore
alveolar macrophage	3 studies	23% ± 6%	Explore
monocyte	3 studies	22% ± 5%	Explore
type II pneumocyte	3 studies	21% ± 4%	Explore
granule cell	3 studies	19% ± 2%	Explore
mural cell	3 studies	37% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	12 studies	32% ± 18%	Explore
peripheral blood	9 studies	22% ± 3%	Explore
eye	5 studies	41% ± 11%	Explore
heart	4 studies	32% ± 4%	Explore
lung	4 studies	21% ± 5%	Explore
adipose	4 studies	26% ± 4%	Explore
kidney	3 studies	19% ± 4%	Explore
lymph node	3 studies	17% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	1178.59	244 / 245	100%	16.20	502 / 502
thymus	100%	1439.27	653 / 653	100%	20.50	602 / 605
kidney	100%	923.69	89 / 89	99%	17.23	896 / 901
skin	100%	1042.65	1808 / 1809	99%	21.19	469 / 472
lung	100%	1774.78	578 / 578	99%	14.14	1146 / 1155
breast	100%	1746.93	459 / 459	99%	16.07	1107 / 1118
esophagus	100%	1155.80	1445 / 1445	99%	11.92	181 / 183
uterus	100%	1406.36	170 / 170	98%	13.67	450 / 459
bladder	100%	1314.62	21 / 21	98%	12.22	494 / 504
adrenal gland	100%	920.57	258 / 258	97%	14.86	223 / 230
stomach	100%	929.69	359 / 359	97%	11.53	277 / 286
intestine	100%	1198.73	966 / 966	96%	10.92	508 / 527
pancreas	98%	644.45	321 / 328	98%	16.44	175 / 178
brain	94%	721.45	2496 / 2642	100%	20.67	705 / 705
ovary	100%	1047.48	180 / 180	92%	6.25	395 / 430
liver	86%	397.25	195 / 226	93%	8.06	378 / 406
adipose	100%	2108.46	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	30.32	29 / 29
muscle	100%	4282.75	803 / 803	0%	0	0 / 0
spleen	100%	1622.52	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.63	45 / 45
blood vessel	100%	2040.88	1334 / 1335	0%	0	0 / 0
heart	99%	1676.88	849 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	11.75	75 / 80
peripheral blood	83%	1154.79	774 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1900244	Biological process	positive regulation of synaptic vesicle endocytosis
GO_0006470	Biological process	protein dephosphorylation
GO_0070886	Biological process	positive regulation of calcineurin-NFAT signaling cascade
GO_0033173	Biological process	calcineurin-NFAT signaling cascade
GO_1905665	Biological process	positive regulation of calcium ion import across plasma membrane
GO_0097720	Biological process	calcineurin-mediated signaling
GO_1905949	Biological process	negative regulation of calcium ion import across plasma membrane
GO_0098978	Cellular component	glutamatergic synapse
GO_0098793	Cellular component	presynapse
GO_0005739	Cellular component	mitochondrion
GO_0005955	Cellular component	calcineurin complex
GO_0005829	Cellular component	cytosol
GO_0008287	Cellular component	protein serine/threonine phosphatase complex
GO_0005737	Cellular component	cytoplasm
GO_0017018	Molecular function	myosin phosphatase activity
GO_0046872	Molecular function	metal ion binding
GO_0033192	Molecular function	calmodulin-dependent protein phosphatase activity
GO_0005516	Molecular function	calmodulin binding
GO_0005515	Molecular function	protein binding
GO_0004723	Molecular function	calcium-dependent protein serine/threonine phosphatase activity

IV. Literature review

[source]

Gene name	PPP3CC
Protein name	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform) Protein phosphatase 3 catalytic subunit gamma Serine/threonine-protein phosphatase (EC 3.1.3.16)
Synonyms	CNA3 CALNA3 hCG_15020
Description	FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. .
Accessions	G3V111 H0YB04 ENST00000521651.5 E5RJH4 ENST00000523620.1 ENST00000289963.12 [P48454-2] ENST00000522000.1 ENST00000397775.7 [P48454-3] ENST00000240139.10 [P48454-1] ENST00000522034.5 ENST00000518852.5 H0YB02 P48454 H0YC26

PPP3CC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review