PNRC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	27 studies	30% ± 7%	Explore
natural killer cell	26 studies	27% ± 7%	Explore
fibroblast	26 studies	31% ± 12%	Explore
CD4-positive, alpha-beta T cell	22 studies	26% ± 8%	Explore
CD8-positive, alpha-beta T cell	22 studies	25% ± 7%	Explore
pericyte	20 studies	26% ± 8%	Explore
smooth muscle cell	20 studies	29% ± 8%	Explore
T cell	18 studies	25% ± 7%	Explore
memory B cell	18 studies	30% ± 9%	Explore
naive B cell	18 studies	30% ± 9%	Explore
endothelial cell	17 studies	29% ± 9%	Explore
macrophage	16 studies	24% ± 8%	Explore
classical monocyte	16 studies	24% ± 10%	Explore
non-classical monocyte	16 studies	26% ± 12%	Explore
gamma-delta T cell	14 studies	30% ± 12%	Explore
regulatory T cell	14 studies	30% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	29% ± 10%	Explore
conventional dendritic cell	13 studies	29% ± 14%	Explore
epithelial cell	13 studies	34% ± 20%	Explore
monocyte	12 studies	22% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	24% ± 6%	Explore
connective tissue cell	12 studies	29% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	27% ± 9%	Explore
mature NK T cell	11 studies	27% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	29% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	29% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	31% ± 10%	Explore
capillary endothelial cell	10 studies	22% ± 7%	Explore
plasmacytoid dendritic cell	10 studies	23% ± 10%	Explore
basal cell	10 studies	27% ± 7%	Explore
mucosal invariant T cell	9 studies	26% ± 5%	Explore
endothelial cell of vascular tree	9 studies	31% ± 8%	Explore
endothelial cell of lymphatic vessel	8 studies	25% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	29% ± 12%	Explore
myofibroblast cell	8 studies	26% ± 8%	Explore
dendritic cell	7 studies	31% ± 22%	Explore
mast cell	7 studies	22% ± 5%	Explore
precursor B cell	7 studies	42% ± 17%	Explore
secretory cell	7 studies	35% ± 8%	Explore
type II pneumocyte	6 studies	26% ± 12%	Explore
leukocyte	6 studies	25% ± 7%	Explore
kidney loop of Henle epithelial cell	6 studies	23% ± 3%	Explore
endothelial cell of artery	6 studies	21% ± 7%	Explore
myeloid cell	6 studies	32% ± 9%	Explore
ciliated cell	6 studies	28% ± 11%	Explore
T follicular helper cell	6 studies	27% ± 1%	Explore
type I pneumocyte	5 studies	35% ± 9%	Explore
hematopoietic precursor cell	5 studies	37% ± 16%	Explore
progenitor cell	5 studies	26% ± 5%	Explore
transit amplifying cell	5 studies	20% ± 4%	Explore
pro-B cell	5 studies	40% ± 9%	Explore
innate lymphoid cell	5 studies	25% ± 3%	Explore
immature B cell	5 studies	36% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	29% ± 9%	Explore
vein endothelial cell	5 studies	27% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	26% ± 5%	Explore
renal alpha-intercalated cell	4 studies	31% ± 2%	Explore
goblet cell	4 studies	18% ± 2%	Explore
hematopoietic stem cell	4 studies	39% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	35% ± 4%	Explore
abnormal cell	4 studies	25% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 5%	Explore
glomerular endothelial cell	3 studies	21% ± 4%	Explore
enterocyte	3 studies	16% ± 1%	Explore
neural crest cell	3 studies	21% ± 2%	Explore
placental villous trophoblast	3 studies	23% ± 4%	Explore
lymphocyte	3 studies	34% ± 5%	Explore
plasma cell	3 studies	28% ± 7%	Explore
Mueller cell	3 studies	25% ± 7%	Explore
acinar cell	3 studies	35% ± 17%	Explore
germinal center B cell	3 studies	34% ± 1%	Explore
luminal cell of prostate epithelium	3 studies	33% ± 9%	Explore
pancreatic ductal cell	3 studies	54% ± 24%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	51% ± 19%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 13%	Explore
T-helper 17 cell	3 studies	23% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	26% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	24% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	27% ± 8%	Explore
lung	10 studies	25% ± 5%	Explore
kidney	6 studies	20% ± 4%	Explore
intestine	5 studies	22% ± 5%	Explore
uterus	5 studies	30% ± 10%	Explore
bone marrow	4 studies	28% ± 13%	Explore
breast	4 studies	27% ± 6%	Explore
placenta	3 studies	19% ± 0%	Explore
eye	3 studies	24% ± 4%	Explore
thymus	3 studies	34% ± 16%	Explore
prostate	3 studies	30% ± 8%	Explore
brain	3 studies	20% ± 6%	Explore
lymph node	3 studies	24% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	5417.58	459 / 459	100%	119.51	1118 / 1118
esophagus	100%	4333.01	1445 / 1445	100%	89.61	183 / 183
lung	100%	6307.59	578 / 578	100%	74.04	1155 / 1155
ovary	100%	5613.53	180 / 180	100%	98.19	430 / 430
prostate	100%	4566.75	245 / 245	100%	103.05	502 / 502
thymus	100%	6833.59	653 / 653	100%	130.33	605 / 605
uterus	100%	5705.05	170 / 170	100%	84.66	459 / 459
intestine	100%	5807.54	966 / 966	100%	92.63	526 / 527
stomach	100%	4245.86	359 / 359	100%	95.76	285 / 286
bladder	100%	4731.05	21 / 21	100%	83.89	502 / 504
kidney	100%	5454.24	89 / 89	99%	72.34	896 / 901
brain	100%	2770.42	2634 / 2642	100%	60.48	703 / 705
pancreas	99%	2055.10	325 / 328	99%	70.25	176 / 178
adrenal gland	100%	5182.43	258 / 258	98%	46.08	225 / 230
skin	100%	3636.11	1807 / 1809	95%	63.98	447 / 472
liver	100%	1760.90	226 / 226	90%	29.78	365 / 406
adipose	100%	6182.42	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	108.75	29 / 29
spleen	100%	5123.10	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	70.68	45 / 45
ureter	0%	0	0 / 0	100%	30.56	1 / 1
blood vessel	100%	5390.36	1334 / 1335	0%	0	0 / 0
heart	99%	3025.91	855 / 861	0%	0	0 / 0
muscle	98%	2036.39	789 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	93%	44.85	74 / 80
peripheral blood	84%	3122.06	776 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0031087	Biological process	deadenylation-independent decapping of nuclear-transcribed mRNA
GO_0000184	Biological process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0000932	Cellular component	P-body
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PNRC2
Protein name	Proline rich nuclear receptor coactivator 2 Proline-rich nuclear receptor coactivator 2
Synonyms	HSPC208
Description	FUNCTION: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery . May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs . Required for UPF1/RENT1 localization to the P-body . Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Also acts as a nuclear receptor coactivator . May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity). .
Accessions	ENST00000374468.1 [Q9NPJ4-1] ENST00000647887.1 [Q9NPJ4-1] ENST00000334351.8 [Q9NPJ4-1] ENST00000579103.1 Q9NPJ4 J3KS97

PNRC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review