PCGF5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
non-classical monocyte	20 studies	32% ± 15%	Explore
B cell	18 studies	22% ± 7%	Explore
astrocyte	18 studies	40% ± 19%	Explore
endothelial cell	17 studies	27% ± 11%	Explore
oligodendrocyte	16 studies	41% ± 16%	Explore
natural killer cell	13 studies	21% ± 5%	Explore
naive B cell	12 studies	21% ± 6%	Explore
CD4-positive, alpha-beta T cell	12 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	12 studies	19% ± 5%	Explore
smooth muscle cell	11 studies	25% ± 7%	Explore
oligodendrocyte precursor cell	11 studies	33% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	23% ± 4%	Explore
fibroblast	10 studies	24% ± 13%	Explore
GABAergic neuron	9 studies	48% ± 26%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	21% ± 4%	Explore
glutamatergic neuron	9 studies	45% ± 25%	Explore
memory B cell	9 studies	21% ± 4%	Explore
mucosal invariant T cell	9 studies	22% ± 3%	Explore
epithelial cell	9 studies	31% ± 15%	Explore
gamma-delta T cell	9 studies	23% ± 7%	Explore
erythrocyte	8 studies	30% ± 13%	Explore
classical monocyte	8 studies	24% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	20% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	24% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	23% ± 4%	Explore
macrophage	8 studies	24% ± 7%	Explore
regulatory T cell	8 studies	17% ± 1%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	24% ± 4%	Explore
platelet	7 studies	20% ± 5%	Explore
T cell	6 studies	21% ± 5%	Explore
monocyte	6 studies	20% ± 3%	Explore
Mueller cell	6 studies	35% ± 13%	Explore
adipocyte	5 studies	23% ± 3%	Explore
cardiac muscle cell	5 studies	31% ± 7%	Explore
basal cell	5 studies	29% ± 15%	Explore
type I pneumocyte	5 studies	24% ± 6%	Explore
goblet cell	5 studies	32% ± 20%	Explore
mature NK T cell	5 studies	20% ± 2%	Explore
precursor B cell	4 studies	24% ± 8%	Explore
plasma cell	4 studies	28% ± 9%	Explore
ciliated cell	4 studies	23% ± 4%	Explore
lymphocyte	4 studies	33% ± 12%	Explore
retina horizontal cell	4 studies	24% ± 8%	Explore
hepatocyte	4 studies	42% ± 24%	Explore
dendritic cell	4 studies	36% ± 20%	Explore
club cell	4 studies	18% ± 4%	Explore
endothelial cell of lymphatic vessel	4 studies	21% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	24% ± 3%	Explore
interneuron	4 studies	66% ± 22%	Explore
microglial cell	4 studies	20% ± 4%	Explore
type B pancreatic cell	3 studies	39% ± 16%	Explore
leukocyte	3 studies	27% ± 7%	Explore
conventional dendritic cell	3 studies	32% ± 11%	Explore
plasmablast	3 studies	32% ± 16%	Explore
neuron	3 studies	35% ± 18%	Explore
myeloid cell	3 studies	22% ± 4%	Explore
retinal pigment epithelial cell	3 studies	32% ± 18%	Explore
mesothelial cell	3 studies	22% ± 5%	Explore
mononuclear phagocyte	3 studies	21% ± 2%	Explore
amacrine cell	3 studies	23% ± 8%	Explore
retinal rod cell	3 studies	22% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	29% ± 10%	Explore
type II pneumocyte	3 studies	19% ± 2%	Explore
pancreatic A cell	3 studies	35% ± 10%	Explore
pancreatic ductal cell	3 studies	38% ± 14%	Explore
neural progenitor cell	3 studies	40% ± 16%	Explore
ependymal cell	3 studies	52% ± 7%	Explore
enteroendocrine cell	3 studies	19% ± 2%	Explore
intestinal crypt stem cell	3 studies	20% ± 3%	Explore
T follicular helper cell	3 studies	22% ± 5%	Explore
Schwann cell	3 studies	36% ± 22%	Explore
pericyte	3 studies	31% ± 19%	Explore
transit amplifying cell	3 studies	34% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	18% ± 0%	Explore
double negative thymocyte	3 studies	36% ± 20%	Explore
mural cell	3 studies	29% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	41% ± 21%	Explore
peripheral blood	10 studies	24% ± 6%	Explore
eye	5 studies	30% ± 16%	Explore
lung	4 studies	20% ± 2%	Explore
pancreas	3 studies	34% ± 14%	Explore
heart	3 studies	23% ± 2%	Explore
liver	3 studies	34% ± 11%	Explore
intestine	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	4065.67	966 / 966	100%	27.82	527 / 527
ovary	100%	3742.16	180 / 180	100%	21.47	430 / 430
esophagus	100%	3160.52	1443 / 1445	100%	31.17	183 / 183
brain	100%	4119.49	2641 / 2642	100%	32.29	703 / 705
prostate	100%	3496.26	244 / 245	100%	21.87	501 / 502
lung	100%	4355.25	577 / 578	99%	24.08	1149 / 1155
stomach	100%	2920.21	359 / 359	99%	30.70	284 / 286
liver	100%	2553.44	226 / 226	99%	18.58	403 / 406
thymus	100%	3611.56	652 / 653	99%	24.56	601 / 605
adrenal gland	100%	6773.45	258 / 258	99%	23.28	228 / 230
kidney	100%	3352.88	89 / 89	99%	31.89	891 / 901
breast	100%	3427.64	459 / 459	98%	22.73	1100 / 1118
pancreas	99%	1892.33	324 / 328	99%	23.02	177 / 178
uterus	100%	3323.18	170 / 170	98%	17.59	449 / 459
bladder	100%	3611.24	21 / 21	97%	18.66	490 / 504
skin	100%	3363.86	1805 / 1809	91%	15.95	429 / 472
adipose	100%	3633.00	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9793.49	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	27.76	29 / 29
muscle	100%	4329.26	803 / 803	0%	0	0 / 0
peripheral blood	100%	5703.36	929 / 929	0%	0	0 / 0
spleen	100%	3049.82	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	20.05	45 / 45
ureter	0%	0	0 / 0	100%	11.38	1 / 1
heart	96%	3651.27	826 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	56%	6.14	45 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060816	Biological process	random inactivation of X chromosome
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0031519	Cellular component	PcG protein complex
GO_0005813	Cellular component	centrosome
GO_0035102	Cellular component	PRC1 complex
GO_0005654	Cellular component	nucleoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0000805	Cellular component	X chromosome
GO_0005634	Cellular component	nucleus
GO_0140862	Molecular function	histone H2AK119 ubiquitin ligase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	PCGF5
Protein name	Polycomb group RING finger protein 5 (RING finger protein 159)
Synonyms	RNF159
Description	FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity . Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). .
Accessions	Q86SE9 ENST00000336126.6 [Q86SE9-1] ENST00000543648.5 [Q86SE9-1] ENST00000614189.4 [Q86SE9-1]

PCGF5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review