Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 38 studies | 42% ± 17% | |
| endothelial cell | 31 studies | 42% ± 18% | |
| pericyte | 25 studies | 35% ± 15% | |
| smooth muscle cell | 25 studies | 44% ± 15% | |
| astrocyte | 20 studies | 58% ± 18% | |
| mast cell | 18 studies | 27% ± 13% | |
| ciliated cell | 15 studies | 34% ± 16% | |
| oligodendrocyte | 15 studies | 44% ± 14% | |
| oligodendrocyte precursor cell | 15 studies | 53% ± 20% | |
| connective tissue cell | 15 studies | 35% ± 16% | |
| basal cell | 13 studies | 34% ± 17% | |
| glutamatergic neuron | 12 studies | 73% ± 22% | |
| epithelial cell | 12 studies | 36% ± 22% | |
| GABAergic neuron | 11 studies | 66% ± 24% | |
| myofibroblast cell | 11 studies | 46% ± 18% | |
| mesothelial cell | 11 studies | 44% ± 17% | |
| adipocyte | 11 studies | 60% ± 21% | |
| neuron | 8 studies | 50% ± 19% | |
| amacrine cell | 7 studies | 33% ± 11% | |
| microglial cell | 7 studies | 38% ± 24% | |
| retinal ganglion cell | 7 studies | 58% ± 20% | |
| secretory cell | 6 studies | 22% ± 10% | |
| interneuron | 6 studies | 65% ± 14% | |
| club cell | 6 studies | 37% ± 15% | |
| type I pneumocyte | 6 studies | 34% ± 9% | |
| type II pneumocyte | 6 studies | 32% ± 12% | |
| retinal cone cell | 6 studies | 58% ± 17% | |
| cardiac muscle cell | 6 studies | 55% ± 21% | |
| vein endothelial cell | 6 studies | 32% ± 17% | |
| capillary endothelial cell | 5 studies | 37% ± 10% | |
| progenitor cell | 5 studies | 51% ± 23% | |
| abnormal cell | 5 studies | 36% ± 16% | |
| adventitial cell | 5 studies | 35% ± 18% | |
| Mueller cell | 5 studies | 34% ± 18% | |
| endothelial cell of vascular tree | 5 studies | 34% ± 7% | |
| glomerular endothelial cell | 4 studies | 57% ± 6% | |
| kidney distal convoluted tubule epithelial cell | 4 studies | 25% ± 3% | |
| granule cell | 4 studies | 52% ± 20% | |
| muscle cell | 4 studies | 44% ± 19% | |
| megakaryocyte-erythroid progenitor cell | 4 studies | 44% ± 13% | |
| goblet cell | 4 studies | 37% ± 23% | |
| ionocyte | 3 studies | 40% ± 4% | |
| epithelial cell of proximal tubule | 3 studies | 43% ± 13% | |
| renal alpha-intercalated cell | 3 studies | 33% ± 8% | |
| interstitial cell of Cajal | 3 studies | 51% ± 12% | |
| GABAergic interneuron | 3 studies | 67% ± 5% | |
| glial cell | 3 studies | 41% ± 10% | |
| brush cell | 3 studies | 34% ± 12% | |
| serous secreting cell | 3 studies | 18% ± 2% | |
| endocardial cell | 3 studies | 41% ± 11% | |
| GABAergic amacrine cell | 3 studies | 66% ± 11% | |
| OFF-bipolar cell | 3 studies | 44% ± 12% | |
| ON-bipolar cell | 3 studies | 34% ± 14% | |
| retinal rod cell | 3 studies | 28% ± 7% | |
| luminal hormone-sensing cell of mammary gland | 3 studies | 33% ± 6% | |
| hepatocyte | 3 studies | 36% ± 15% | |
| ependymal cell | 3 studies | 65% ± 11% | |
| megakaryocyte | 3 studies | 64% ± 22% | |
| enteroendocrine cell | 3 studies | 39% ± 13% | |
| intestinal crypt stem cell | 3 studies | 20% ± 4% | |
| chondrocyte | 3 studies | 46% ± 10% | |
| respiratory goblet cell | 3 studies | 45% ± 17% | |
| hematopoietic stem cell | 3 studies | 22% ± 2% | |
| kidney loop of Henle epithelial cell | 3 studies | 38% ± 16% | |
| mucus secreting cell | 3 studies | 52% ± 15% | |
| myoepithelial cell | 3 studies | 43% ± 28% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 9487.93 | 180 / 180 | 100% | 29.89 | 428 / 430 |
| breast | 100% | 7419.56 | 459 / 459 | 99% | 65.24 | 1102 / 1118 |
| brain | 98% | 4187.69 | 2601 / 2642 | 99% | 25.76 | 698 / 705 |
| thymus | 100% | 6000.04 | 653 / 653 | 97% | 24.87 | 588 / 605 |
| prostate | 100% | 7613.31 | 245 / 245 | 96% | 17.22 | 484 / 502 |
| pancreas | 100% | 4960.14 | 327 / 328 | 90% | 12.45 | 161 / 178 |
| uterus | 100% | 30882.81 | 170 / 170 | 87% | 23.95 | 401 / 459 |
| adrenal gland | 100% | 7803.41 | 258 / 258 | 81% | 11.77 | 187 / 230 |
| bladder | 100% | 11151.43 | 21 / 21 | 73% | 11.98 | 368 / 504 |
| esophagus | 100% | 9197.75 | 1442 / 1445 | 73% | 9.98 | 133 / 183 |
| lung | 99% | 4435.35 | 574 / 578 | 73% | 10.00 | 845 / 1155 |
| stomach | 98% | 5501.50 | 351 / 359 | 63% | 7.74 | 181 / 286 |
| kidney | 98% | 3468.29 | 87 / 89 | 58% | 7.36 | 524 / 901 |
| intestine | 100% | 10265.61 | 965 / 966 | 56% | 5.64 | 294 / 527 |
| skin | 97% | 3806.57 | 1750 / 1809 | 12% | 1.69 | 57 / 472 |
| blood vessel | 100% | 6501.78 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.61 | 1 / 1 |
| adipose | 100% | 5434.86 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 6086.19 | 800 / 803 | 0% | 0 | 0 / 0 |
| heart | 91% | 3296.27 | 787 / 861 | 0% | 0 | 0 / 0 |
| spleen | 84% | 1718.63 | 203 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 13.75 | 37 / 45 |
| eye | 0% | 0 | 0 / 0 | 30% | 3.49 | 24 / 80 |
| liver | 4% | 59.24 | 9 / 226 | 12% | 1.24 | 48 / 406 |
| peripheral blood | 2% | 24.19 | 15 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001658 | Biological process | branching involved in ureteric bud morphogenesis |
| GO_0009954 | Biological process | proximal/distal pattern formation |
| GO_0048568 | Biological process | embryonic organ development |
| GO_0010971 | Biological process | positive regulation of G2/M transition of mitotic cell cycle |
| GO_0001779 | Biological process | natural killer cell differentiation |
| GO_0007548 | Biological process | sex differentiation |
| GO_0001655 | Biological process | urogenital system development |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0009887 | Biological process | animal organ morphogenesis |
| GO_2000648 | Biological process | positive regulation of stem cell proliferation |
| GO_0072089 | Biological process | stem cell proliferation |
| GO_0006694 | Biological process | steroid biosynthetic process |
| GO_0001654 | Biological process | eye development |
| GO_0048536 | Biological process | spleen development |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0048706 | Biological process | embryonic skeletal system development |
| GO_0048666 | Biological process | neuron development |
| GO_0030325 | Biological process | adrenal gland development |
| GO_0030326 | Biological process | embryonic limb morphogenesis |
| GO_0048538 | Biological process | thymus development |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0007420 | Biological process | brain development |
| GO_0000086 | Biological process | G2/M transition of mitotic cell cycle |
| GO_0030278 | Biological process | regulation of ossification |
| GO_0035162 | Biological process | embryonic hemopoiesis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0140297 | Molecular function | DNA-binding transcription factor binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0001221 | Molecular function | transcription coregulator binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0001222 | Molecular function | transcription corepressor binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PBX1 |
| Protein name | PBX homeobox 1 (Pre-B-cell leukemia transcription factor 1, isoform CRA_a) PBX homeobox 1 Pre-B-cell leukemia transcription factor 1 Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL) |
| Synonyms | PRL hCG_23011 |
| Description | FUNCTION: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 . Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein . Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 . Acts as a transcriptional activator of PF4 in complex with MEIS1 . Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 . Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). .; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. . |
| Accessions | Q53YC7 ENST00000482110.5 ENST00000699847.1 H0YLM3 ENST00000559578.1 P40424 ENST00000420696.7 [P40424-1] ENST00000559560.1 ENST00000540236.4 A0A8V8TPF7 ENST00000558837.5 H0YLD4 ENST00000627490.2 [P40424-3] ENST00000340699.7 ENST00000560641.5 ENST00000699846.1 ENST00000699848.1 S4R377 F8WA05 H0YLT4 ENST00000485769.5 H0YKH1 ENST00000559240.5 H0YLF5 ENST00000699845.1 [P40424-2] ENST00000367897.5 [P40424-2] H0YLB0 |