PBX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001658Biological processbranching involved in ureteric bud morphogenesis
GO_0009954Biological processproximal/distal pattern formation
GO_0048568Biological processembryonic organ development
GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_0001779Biological processnatural killer cell differentiation
GO_0007548Biological processsex differentiation
GO_0001655Biological processurogenital system development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009887Biological processanimal organ morphogenesis
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0072089Biological processstem cell proliferation
GO_0006694Biological processsteroid biosynthetic process
GO_0001654Biological processeye development
GO_0048536Biological processspleen development
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0048706Biological processembryonic skeletal system development
GO_0048666Biological processneuron development
GO_0030325Biological processadrenal gland development
GO_0030326Biological processembryonic limb morphogenesis
GO_0048538Biological processthymus development
GO_0009952Biological processanterior/posterior pattern specification
GO_0007420Biological processbrain development
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0030278Biological processregulation of ossification
GO_0035162Biological processembryonic hemopoiesis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0001221Molecular functiontranscription coregulator binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0001222Molecular functiontranscription corepressor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePBX1
Protein namePBX homeobox 1 (Pre-B-cell leukemia transcription factor 1, isoform CRA_a)
PBX homeobox 1
Pre-B-cell leukemia transcription factor 1
Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL)
SynonymsPRL
hCG_23011
DescriptionFUNCTION: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 . Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein . Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 . Acts as a transcriptional activator of PF4 in complex with MEIS1 . Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 . Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). .; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. .

AccessionsQ53YC7
ENST00000482110.5
ENST00000699847.1
H0YLM3
ENST00000559578.1
P40424
ENST00000420696.7 [P40424-1]
ENST00000559560.1
ENST00000540236.4
A0A8V8TPF7
ENST00000558837.5
H0YLD4
ENST00000627490.2 [P40424-3]
ENST00000340699.7
ENST00000560641.5
ENST00000699846.1
ENST00000699848.1
S4R377
F8WA05
H0YLT4
ENST00000485769.5
H0YKH1
ENST00000559240.5
H0YLF5
ENST00000699845.1 [P40424-2]
ENST00000367897.5 [P40424-2]
H0YLB0