OFD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	34 studies	25% ± 8%	Explore
natural killer cell	31 studies	25% ± 9%	Explore
CD8-positive, alpha-beta T cell	23 studies	21% ± 5%	Explore
plasmacytoid dendritic cell	20 studies	56% ± 16%	Explore
naive B cell	19 studies	25% ± 5%	Explore
memory B cell	18 studies	25% ± 4%	Explore
CD4-positive, alpha-beta T cell	18 studies	19% ± 4%	Explore
T cell	17 studies	21% ± 5%	Explore
regulatory T cell	17 studies	20% ± 4%	Explore
gamma-delta T cell	15 studies	25% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	24% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	29% ± 7%	Explore
mature NK T cell	14 studies	22% ± 5%	Explore
endothelial cell	14 studies	25% ± 8%	Explore
ciliated cell	13 studies	31% ± 17%	Explore
mucosal invariant T cell	13 studies	24% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	26% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	20% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	20% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	26% ± 8%	Explore
type I pneumocyte	9 studies	23% ± 5%	Explore
conventional dendritic cell	9 studies	25% ± 14%	Explore
fibroblast	9 studies	18% ± 2%	Explore
basal cell	9 studies	24% ± 10%	Explore
microglial cell	8 studies	26% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	22% ± 4%	Explore
macrophage	7 studies	23% ± 5%	Explore
epithelial cell	7 studies	41% ± 24%	Explore
astrocyte	7 studies	31% ± 9%	Explore
oligodendrocyte	7 studies	24% ± 6%	Explore
leukocyte	6 studies	22% ± 5%	Explore
club cell	6 studies	21% ± 4%	Explore
retinal rod cell	6 studies	24% ± 6%	Explore
T follicular helper cell	6 studies	23% ± 4%	Explore
type II pneumocyte	6 studies	22% ± 5%	Explore
oligodendrocyte precursor cell	6 studies	35% ± 11%	Explore
precursor B cell	5 studies	33% ± 11%	Explore
dendritic cell	5 studies	29% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	22% ± 7%	Explore
innate lymphoid cell	5 studies	26% ± 5%	Explore
goblet cell	5 studies	27% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	20% ± 3%	Explore
deuterosomal cell	4 studies	23% ± 1%	Explore
plasma cell	4 studies	23% ± 11%	Explore
immature B cell	4 studies	24% ± 5%	Explore
lymphocyte	4 studies	33% ± 10%	Explore
Mueller cell	4 studies	26% ± 7%	Explore
respiratory goblet cell	4 studies	22% ± 7%	Explore
GABAergic neuron	4 studies	40% ± 16%	Explore
glutamatergic neuron	4 studies	47% ± 18%	Explore
abnormal cell	4 studies	27% ± 6%	Explore
interneuron	4 studies	32% ± 21%	Explore
exhausted T cell	3 studies	25% ± 7%	Explore
progenitor cell	3 studies	16% ± 1%	Explore
pericyte	3 studies	31% ± 16%	Explore
pro-B cell	3 studies	35% ± 2%	Explore
retinal cone cell	3 studies	29% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 4%	Explore
T-helper 17 cell	3 studies	23% ± 6%	Explore
neuron	3 studies	29% ± 6%	Explore
double negative thymocyte	3 studies	26% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	20% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	8 studies	19% ± 3%	Explore
peripheral blood	8 studies	24% ± 13%	Explore
brain	8 studies	33% ± 15%	Explore
eye	5 studies	28% ± 4%	Explore
intestine	4 studies	20% ± 6%	Explore
liver	4 studies	24% ± 5%	Explore
lymph node	3 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	5069.36	653 / 653	100%	33.75	605 / 605
esophagus	100%	2218.32	1444 / 1445	100%	20.01	183 / 183
breast	100%	3130.97	459 / 459	100%	33.41	1117 / 1118
prostate	100%	4474.85	245 / 245	100%	27.18	501 / 502
uterus	100%	4516.85	170 / 170	100%	32.27	458 / 459
bladder	100%	2616.90	21 / 21	100%	26.03	502 / 504
pancreas	100%	2253.74	328 / 328	99%	24.94	177 / 178
lung	100%	2969.22	578 / 578	99%	23.89	1146 / 1155
adrenal gland	100%	1714.57	258 / 258	99%	14.33	228 / 230
brain	100%	1851.27	2630 / 2642	100%	18.96	702 / 705
intestine	100%	2927.66	966 / 966	99%	23.32	520 / 527
ovary	100%	4838.88	180 / 180	98%	17.46	423 / 430
stomach	100%	2816.83	359 / 359	98%	21.39	281 / 286
kidney	100%	2824.39	89 / 89	98%	22.36	882 / 901
skin	100%	2318.57	1808 / 1809	89%	15.29	420 / 472
liver	100%	1434.35	226 / 226	82%	10.57	331 / 406
lymph node	0%	0	0 / 0	100%	28.44	29 / 29
spleen	100%	4314.51	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	11.03	1 / 1
adipose	100%	1820.86	1202 / 1204	0%	0	0 / 0
blood vessel	100%	1904.45	1330 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	22.72	44 / 45
heart	97%	1098.16	834 / 861	0%	0	0 / 0
muscle	93%	809.50	743 / 803	0%	0	0 / 0
peripheral blood	90%	1805.78	837 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	53%	6.28	42 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060271	Biological process	cilium assembly
GO_0000278	Biological process	mitotic cell cycle
GO_0060287	Biological process	epithelial cilium movement involved in determination of left/right asymmetry
GO_0010172	Biological process	embryonic body morphogenesis
GO_0090307	Biological process	mitotic spindle assembly
GO_2000314	Biological process	negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO_0035082	Biological process	axoneme assembly
GO_0007099	Biological process	centriole replication
GO_0005576	Cellular component	extracellular region
GO_0034451	Cellular component	centriolar satellite
GO_0016020	Cellular component	membrane
GO_0005813	Cellular component	centrosome
GO_0031514	Cellular component	motile cilium
GO_0005814	Cellular component	centriole
GO_0005929	Cellular component	cilium
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0036064	Cellular component	ciliary basal body
GO_0005634	Cellular component	nucleus
GO_0043015	Molecular function	gamma-tubulin binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0042802	Molecular function	identical protein binding
GO_0043014	Molecular function	alpha-tubulin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	OFD1
Protein name	OFD1 protein Alternative protein OFD1 Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) OFD1 centriole and centriolar satellite protein Epididymis tissue sperm binding protein Li 5a (Oral-facial-digital syndrome 1, isoform CRA_a)
Synonyms	CXorf5 hCG_1981836
Description	FUNCTION: Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis . Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). .
Accessions	ENST00000380550.6 [O75665-3] ENST00000683284.1 ENST00000683655.1 A0A804HK98 ENST00000682953.1 Q4G0Q0 E9KL37 A6NF31 ENST00000340096.11 [O75665-1] ENST00000683055.1 A0A804HKD3 ENST00000684577.1 L8E7V8 O75665 ENST00000683427.1 A0A804HIZ6 A0A804HK70 Q4VAK3 ENST00000682237.1 [O75665-2] Q6P668 ENST00000380567.6 ENST00000398395.8 A0A804HHU8 ENST00000683713.1 Q7Z7F6 A0A804HL42 ENST00000682562.1

OFD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review