NUDT21 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0180010Biological processco-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
GO_0031124Biological processmRNA 3'-end processing
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0051262Biological processprotein tetramerization
GO_0110104Biological processmRNA alternative polyadenylation
GO_0030154Biological processcell differentiation
GO_0051290Biological processprotein heterotetramerization
GO_2000975Biological processpositive regulation of pro-B cell differentiation
GO_2000738Biological processpositive regulation of stem cell differentiation
GO_0034451Cellular componentcentriolar satellite
GO_0005813Cellular componentcentrosome
GO_0005847Cellular componentmRNA cleavage and polyadenylation specificity factor complex
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0005849Cellular componentmRNA cleavage factor complex
GO_0042382Cellular componentparaspeckles
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0003682Molecular functionchromatin binding
GO_0042802Molecular functionidentical protein binding
GO_0003729Molecular functionmRNA binding
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameNUDT21
Protein nameNudix hydrolase 21
Cleavage and polyadenylation specificity factor subunit 5 (Nucleoside diphosphate-linked moiety X motif 21)
Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit)
SynonymsCPSF5
CPSF25
CFIM25
DescriptionFUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs . CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) . Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation . The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs . NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7 . Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing . The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA . Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function (By similarity). Binds to chromatin (By similarity). Binds to, but does not hydrolyze mono- and di-adenosine nucleotides . .

AccessionsENST00000300291.10
O43809
H3BV41
ENST00000566340.5
ENST00000568822.1
H3BND3