MFF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	19 studies	23% ± 6%	Explore
fibroblast	18 studies	22% ± 8%	Explore
B cell	16 studies	24% ± 6%	Explore
CD4-positive, alpha-beta T cell	16 studies	22% ± 5%	Explore
regulatory T cell	16 studies	23% ± 4%	Explore
CD8-positive, alpha-beta T cell	15 studies	23% ± 5%	Explore
naive B cell	15 studies	22% ± 5%	Explore
endothelial cell	13 studies	27% ± 8%	Explore
oligodendrocyte	12 studies	31% ± 14%	Explore
memory B cell	12 studies	21% ± 3%	Explore
astrocyte	12 studies	29% ± 12%	Explore
oligodendrocyte precursor cell	12 studies	36% ± 18%	Explore
classical monocyte	11 studies	22% ± 9%	Explore
smooth muscle cell	11 studies	22% ± 5%	Explore
gamma-delta T cell	11 studies	24% ± 11%	Explore
macrophage	11 studies	21% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	25% ± 5%	Explore
T cell	10 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	24% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	22% ± 5%	Explore
pericyte	10 studies	21% ± 5%	Explore
plasma cell	9 studies	32% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	22% ± 4%	Explore
mucosal invariant T cell	9 studies	20% ± 3%	Explore
epithelial cell	9 studies	38% ± 15%	Explore
plasmablast	8 studies	43% ± 20%	Explore
connective tissue cell	8 studies	22% ± 6%	Explore
plasmacytoid dendritic cell	8 studies	26% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	23% ± 4%	Explore
conventional dendritic cell	7 studies	30% ± 17%	Explore
myofibroblast cell	7 studies	26% ± 8%	Explore
glutamatergic neuron	7 studies	43% ± 25%	Explore
microglial cell	7 studies	25% ± 7%	Explore
abnormal cell	7 studies	26% ± 11%	Explore
GABAergic neuron	7 studies	39% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	24% ± 8%	Explore
mature NK T cell	6 studies	21% ± 2%	Explore
endothelial cell of lymphatic vessel	6 studies	20% ± 4%	Explore
Mueller cell	6 studies	37% ± 9%	Explore
hematopoietic precursor cell	5 studies	27% ± 13%	Explore
non-classical monocyte	5 studies	27% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	24% ± 3%	Explore
kidney loop of Henle epithelial cell	5 studies	19% ± 3%	Explore
neuron	5 studies	37% ± 14%	Explore
mesothelial cell	5 studies	30% ± 11%	Explore
precursor B cell	5 studies	29% ± 8%	Explore
basal cell	5 studies	32% ± 12%	Explore
retinal rod cell	5 studies	25% ± 7%	Explore
monocyte	5 studies	19% ± 3%	Explore
T follicular helper cell	5 studies	21% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
interneuron	5 studies	39% ± 18%	Explore
pancreatic A cell	4 studies	30% ± 9%	Explore
exhausted T cell	4 studies	26% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	24% ± 8%	Explore
retinal ganglion cell	4 studies	58% ± 24%	Explore
hematopoietic stem cell	4 studies	18% ± 3%	Explore
immature B cell	4 studies	23% ± 2%	Explore
type I pneumocyte	4 studies	20% ± 3%	Explore
amacrine cell	4 studies	37% ± 11%	Explore
retina horizontal cell	4 studies	31% ± 10%	Explore
retinal pigment epithelial cell	4 studies	30% ± 15%	Explore
ciliated cell	4 studies	28% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	24% ± 1%	Explore
dendritic cell	4 studies	37% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 6%	Explore
goblet cell	4 studies	20% ± 5%	Explore
type B pancreatic cell	3 studies	35% ± 5%	Explore
epithelial cell of proximal tubule	3 studies	18% ± 3%	Explore
renal alpha-intercalated cell	3 studies	21% ± 6%	Explore
pro-B cell	3 studies	27% ± 3%	Explore
mononuclear phagocyte	3 studies	23% ± 9%	Explore
rod bipolar cell	3 studies	18% ± 2%	Explore
pancreatic ductal cell	3 studies	41% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	35% ± 23%	Explore
intestinal crypt stem cell	3 studies	24% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	26% ± 10%	Explore
transit amplifying cell	3 studies	29% ± 13%	Explore
double negative thymocyte	3 studies	33% ± 13%	Explore
adipocyte	3 studies	23% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	23% ± 6%	Explore
brain	13 studies	32% ± 20%	Explore
eye	9 studies	26% ± 10%	Explore
lung	7 studies	23% ± 6%	Explore
intestine	5 studies	22% ± 11%	Explore
kidney	4 studies	19% ± 3%	Explore
lymph node	4 studies	22% ± 7%	Explore
pancreas	3 studies	34% ± 7%	Explore
bone marrow	3 studies	18% ± 1%	Explore
adipose	3 studies	21% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	4725.52	2642 / 2642	100%	67.53	705 / 705
esophagus	100%	3452.56	1445 / 1445	100%	26.10	183 / 183
ovary	100%	4010.97	180 / 180	100%	31.47	430 / 430
prostate	100%	3424.19	245 / 245	100%	31.57	502 / 502
uterus	100%	4133.36	170 / 170	100%	30.83	459 / 459
breast	100%	3229.54	459 / 459	100%	31.60	1117 / 1118
skin	100%	3390.62	1807 / 1809	100%	37.75	472 / 472
intestine	100%	3828.56	966 / 966	100%	29.52	526 / 527
kidney	100%	4163.91	89 / 89	100%	31.46	899 / 901
pancreas	100%	2234.49	327 / 328	100%	27.28	178 / 178
stomach	100%	2703.63	359 / 359	100%	27.69	285 / 286
bladder	100%	3589.24	21 / 21	100%	27.41	502 / 504
adrenal gland	100%	3961.40	258 / 258	100%	30.55	229 / 230
liver	100%	1496.62	225 / 226	100%	22.38	406 / 406
thymus	100%	2961.67	653 / 653	100%	29.95	602 / 605
lung	99%	2612.93	574 / 578	100%	30.11	1155 / 1155
adipose	100%	3228.87	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	44.85	80 / 80
lymph node	0%	0	0 / 0	100%	31.48	29 / 29
muscle	100%	4202.85	803 / 803	0%	0	0 / 0
spleen	100%	2819.63	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	27.93	45 / 45
ureter	0%	0	0 / 0	100%	14.46	1 / 1
blood vessel	100%	4225.46	1334 / 1335	0%	0	0 / 0
heart	97%	3248.55	839 / 861	0%	0	0 / 0
peripheral blood	95%	2565.68	880 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0090200	Biological process	positive regulation of release of cytochrome c from mitochondria
GO_0000266	Biological process	mitochondrial fission
GO_0010821	Biological process	regulation of mitochondrion organization
GO_0090141	Biological process	positive regulation of mitochondrial fission
GO_0008053	Biological process	mitochondrial fusion
GO_0043653	Biological process	mitochondrial fragmentation involved in apoptotic process
GO_0007005	Biological process	mitochondrion organization
GO_0016559	Biological process	peroxisome fission
GO_0090314	Biological process	positive regulation of protein targeting to membrane
GO_0001836	Biological process	release of cytochrome c from mitochondria
GO_0006626	Biological process	protein targeting to mitochondrion
GO_1900063	Biological process	regulation of peroxisome organization
GO_0005739	Cellular component	mitochondrion
GO_0031966	Cellular component	mitochondrial membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005777	Cellular component	peroxisome
GO_0008021	Cellular component	synaptic vesicle
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0042803	Molecular function	protein homodimerization activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MFF
Protein name	Mitochondrial fission factor
Synonyms	GL004 hCG_2013339 C2orf33 AD030 AD033
Description	FUNCTION: Plays a role in mitochondrial and peroxisomal fission . Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface . May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. . FUNCTION: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. .
Accessions	ENST00000436237.5 ENST00000707109.1 ENST00000409616.5 ENST00000443428.6 ENST00000456345.2 ENST00000707110.1 E9PK16 A0A9H3ZVE5 A0A9L9PY92 ENST00000534203.5 C9J846 Q9GZY8 C9JHF5 C9JI76 ENST00000530359.5 E9PPW6 ENST00000524634.5 A0A9L9PXN3 ENST00000304593.14 [Q9GZY8-2] C9JAF1 ENST00000349901.11 [Q9GZY8-5] ENST00000392059.6 ENST00000418961.5 ENST00000525195.5 E9PPR7 ENST00000531278.5 A0A9L9PYL0 C9JU19 ENST00000337110.11 [Q9GZY8-3] H7C433 ENST00000707111.1 ENST00000353339.8 [Q9GZY8-1] ENST00000423098.5 ENST00000409565.5 [Q9GZY8-4] E9PKS0 A0A0A0MS29 ENST00000354503.10 [Q9GZY8-4] ENST00000452930.5 E9PQX8

MFF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review