MATR3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
regulatory T cell	15 studies	32% ± 14%	Explore
natural killer cell	12 studies	30% ± 13%	Explore
B cell	12 studies	32% ± 11%	Explore
CD8-positive, alpha-beta T cell	11 studies	31% ± 10%	Explore
CD4-positive, alpha-beta T cell	10 studies	29% ± 11%	Explore
T cell	9 studies	34% ± 17%	Explore
fibroblast	8 studies	27% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	33% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	33% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	31% ± 15%	Explore
epithelial cell	7 studies	34% ± 18%	Explore
memory B cell	7 studies	34% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	35% ± 18%	Explore
macrophage	6 studies	33% ± 13%	Explore
pericyte	6 studies	34% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	31% ± 17%	Explore
mucosal invariant T cell	6 studies	33% ± 18%	Explore
naive B cell	6 studies	33% ± 19%	Explore
plasmacytoid dendritic cell	6 studies	34% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	30% ± 17%	Explore
astrocyte	5 studies	41% ± 17%	Explore
endothelial cell	5 studies	53% ± 20%	Explore
oligodendrocyte precursor cell	5 studies	50% ± 21%	Explore
basal cell	5 studies	35% ± 20%	Explore
ciliated cell	5 studies	40% ± 18%	Explore
conventional dendritic cell	5 studies	35% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	31% ± 9%	Explore
gamma-delta T cell	5 studies	30% ± 18%	Explore
plasma cell	4 studies	28% ± 7%	Explore
oligodendrocyte	4 studies	46% ± 17%	Explore
pancreatic A cell	3 studies	58% ± 23%	Explore
type B pancreatic cell	3 studies	60% ± 23%	Explore
glial cell	3 studies	42% ± 23%	Explore
interneuron	3 studies	44% ± 28%	Explore
microglial cell	3 studies	44% ± 11%	Explore
neuron	3 studies	59% ± 22%	Explore
erythroblast	3 studies	37% ± 20%	Explore
hematopoietic stem cell	3 studies	28% ± 9%	Explore
precursor B cell	3 studies	25% ± 10%	Explore
myeloid cell	3 studies	23% ± 6%	Explore
myofibroblast cell	3 studies	38% ± 7%	Explore
smooth muscle cell	3 studies	31% ± 6%	Explore
dendritic cell	3 studies	17% ± 0%	Explore
endothelial cell of lymphatic vessel	3 studies	32% ± 9%	Explore
abnormal cell	3 studies	49% ± 15%	Explore
classical monocyte	3 studies	29% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	32% ± 12%	Explore
endothelial cell of vascular tree	3 studies	29% ± 4%	Explore
exhausted T cell	3 studies	42% ± 3%	Explore
GABAergic neuron	3 studies	83% ± 6%	Explore
glutamatergic neuron	3 studies	90% ± 5%	Explore
goblet cell	3 studies	31% ± 11%	Explore
non-classical monocyte	3 studies	29% ± 8%	Explore
mononuclear phagocyte	3 studies	31% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	22% ± 2%	Explore
mature NK T cell	3 studies	32% ± 6%	Explore
plasmablast	3 studies	47% ± 18%	Explore
double negative thymocyte	3 studies	36% ± 25%	Explore
double-positive, alpha-beta thymocyte	3 studies	39% ± 25%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	32% ± 13%	Explore
brain	5 studies	66% ± 20%	Explore
lung	4 studies	28% ± 16%	Explore
pancreas	3 studies	58% ± 22%	Explore
skin	3 studies	21% ± 1%	Explore
lymph node	3 studies	28% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	318.38	1445 / 1445	57%	1.08	105 / 183
thymus	100%	458.56	653 / 653	49%	0.81	294 / 605
breast	100%	393.46	459 / 459	37%	0.87	416 / 1118
brain	100%	987.40	2642 / 2642	37%	0.60	261 / 705
kidney	100%	309.44	89 / 89	34%	0.73	304 / 901
pancreas	97%	183.61	317 / 328	30%	0.60	53 / 178
stomach	100%	252.30	358 / 359	21%	0.56	59 / 286
lung	100%	353.93	576 / 578	19%	0.63	221 / 1155
prostate	100%	434.56	245 / 245	19%	0.31	93 / 502
adrenal gland	100%	293.24	258 / 258	17%	0.24	39 / 230
uterus	100%	576.90	170 / 170	16%	0.32	72 / 459
skin	100%	273.49	1801 / 1809	15%	0.21	71 / 472
bladder	100%	419.90	21 / 21	14%	0.56	71 / 504
intestine	100%	355.07	966 / 966	13%	0.29	66 / 527
ovary	100%	698.11	180 / 180	8%	0.13	34 / 430
adipose	100%	374.25	1204 / 1204	0%	0	0 / 0
spleen	100%	327.48	241 / 241	0%	0	0 / 0
blood vessel	100%	419.57	1334 / 1335	0%	0	0 / 0
muscle	100%	318.52	801 / 803	0%	0	0 / 0
heart	95%	249.06	821 / 861	0%	0	0 / 0
liver	82%	114.12	185 / 226	4%	0.05	16 / 406
peripheral blood	61%	167.80	565 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	15%	0.23	12 / 80
tonsil	0%	0	0 / 0	7%	0.11	3 / 45
lymph node	0%	0	0 / 0	3%	0.05	1 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002218	Biological process	activation of innate immune response
GO_0003170	Biological process	heart valve development
GO_0001825	Biological process	blastocyst formation
GO_0003281	Biological process	ventricular septum development
GO_0010608	Biological process	post-transcriptional regulation of gene expression
GO_0045087	Biological process	innate immune response
GO_0016363	Cellular component	nuclear matrix
GO_0016020	Cellular component	membrane
GO_0005637	Cellular component	nuclear inner membrane
GO_0005634	Cellular component	nucleus
GO_0035198	Molecular function	miRNA binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0005198	Molecular function	structural molecule activity
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	MATR3
Protein name	Matrin-3 Matrin 3 (cDNA FLJ10526 fis, clone NT2RP2000931, highly similar to Matrin-3) Matrin 3
Synonyms	KIAA0723
Description	FUNCTION: May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway . Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs . May bind to specific miRNA hairpins . .
Accessions	D6RBI2 D6RCM3 ENST00000514488.1 ENST00000502929.5 ENST00000618441.5 [P43243-1] ENST00000509644.5 D6RAY2 ENST00000512876.5 ENST00000510056.5 D6R9N0 P43243 D6R991 D6R9F3 ENST00000515833.2 D6RBK5 ENST00000508689.1 D6RBS2 ENST00000504045.5 H0Y8T4 D6RB45 ENST00000503811.5 [P43243-2] ENST00000394805.8 [P43243-1] A0A1B0GX04 D6REM6 ENST00000506147.5 ENST00000513678.5 D6RAM9 ENST00000511249.5 ENST00000514694.5 ENST00000505016.2 A8MXP9 ENST00000504203.5 A0A0R4J2E8 D6R8Z5 ENST00000504023.1 D6RE02 ENST00000361059 D6REK4 D6RIA2 B3KM87 ENST00000502499.5 ENST00000502394.1 ENST00000514528.5 ENST00000504311.5 ENST00000503340.1 ENST00000394800.6

MATR3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review