MARCHF6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	35 studies	30% ± 14%	Explore
fibroblast	29 studies	27% ± 13%	Explore
pericyte	26 studies	24% ± 10%	Explore
smooth muscle cell	24 studies	23% ± 8%	Explore
ciliated cell	19 studies	38% ± 15%	Explore
astrocyte	17 studies	42% ± 19%	Explore
B cell	16 studies	26% ± 10%	Explore
endothelial cell of lymphatic vessel	13 studies	29% ± 14%	Explore
glutamatergic neuron	12 studies	52% ± 25%	Explore
CD8-positive, alpha-beta T cell	12 studies	18% ± 3%	Explore
T cell	11 studies	21% ± 5%	Explore
oligodendrocyte	11 studies	41% ± 16%	Explore
mast cell	11 studies	25% ± 12%	Explore
microglial cell	11 studies	34% ± 15%	Explore
macrophage	11 studies	31% ± 15%	Explore
natural killer cell	10 studies	20% ± 4%	Explore
GABAergic neuron	10 studies	51% ± 23%	Explore
oligodendrocyte precursor cell	10 studies	40% ± 21%	Explore
CD4-positive, alpha-beta T cell	10 studies	22% ± 5%	Explore
basal cell	10 studies	33% ± 18%	Explore
adipocyte	10 studies	29% ± 7%	Explore
type I pneumocyte	9 studies	30% ± 9%	Explore
capillary endothelial cell	9 studies	19% ± 6%	Explore
connective tissue cell	9 studies	27% ± 8%	Explore
endothelial cell of artery	9 studies	20% ± 2%	Explore
memory B cell	9 studies	18% ± 2%	Explore
epithelial cell	9 studies	44% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	21% ± 3%	Explore
myofibroblast cell	8 studies	26% ± 12%	Explore
neuron	8 studies	54% ± 17%	Explore
naive B cell	8 studies	20% ± 2%	Explore
amacrine cell	8 studies	35% ± 15%	Explore
endothelial cell of vascular tree	8 studies	25% ± 15%	Explore
monocyte	7 studies	26% ± 4%	Explore
vein endothelial cell	7 studies	27% ± 18%	Explore
regulatory T cell	7 studies	19% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	22% ± 4%	Explore
mesothelial cell	6 studies	30% ± 14%	Explore
gamma-delta T cell	6 studies	22% ± 9%	Explore
retinal ganglion cell	6 studies	37% ± 19%	Explore
myeloid cell	6 studies	29% ± 13%	Explore
club cell	6 studies	31% ± 10%	Explore
retinal rod cell	6 studies	26% ± 5%	Explore
Mueller cell	6 studies	29% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	19% ± 2%	Explore
type II pneumocyte	6 studies	26% ± 7%	Explore
non-classical monocyte	5 studies	22% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	18% ± 1%	Explore
abnormal cell	5 studies	28% ± 13%	Explore
retinal bipolar neuron	5 studies	33% ± 9%	Explore
mucosal invariant T cell	5 studies	19% ± 3%	Explore
plasma cell	5 studies	38% ± 13%	Explore
retina horizontal cell	5 studies	35% ± 7%	Explore
cardiac muscle cell	5 studies	32% ± 5%	Explore
dendritic cell	5 studies	28% ± 13%	Explore
lymphocyte	5 studies	34% ± 14%	Explore
respiratory goblet cell	5 studies	31% ± 13%	Explore
goblet cell	5 studies	37% ± 25%	Explore
secretory cell	4 studies	23% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	25% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	23% ± 4%	Explore
progenitor cell	4 studies	25% ± 8%	Explore
kidney loop of Henle epithelial cell	4 studies	24% ± 5%	Explore
retinal cone cell	4 studies	31% ± 10%	Explore
retinal pigment epithelial cell	4 studies	39% ± 24%	Explore
T follicular helper cell	4 studies	21% ± 2%	Explore
muscle cell	4 studies	35% ± 21%	Explore
enteroendocrine cell	4 studies	31% ± 17%	Explore
interneuron	4 studies	74% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	22% ± 2%	Explore
ionocyte	3 studies	33% ± 5%	Explore
pancreatic A cell	3 studies	26% ± 13%	Explore
classical monocyte	3 studies	24% ± 6%	Explore
conventional dendritic cell	3 studies	22% ± 5%	Explore
plasmablast	3 studies	31% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	24% ± 4%	Explore
squamous epithelial cell	3 studies	39% ± 29%	Explore
mononuclear phagocyte	3 studies	26% ± 8%	Explore
GABAergic amacrine cell	3 studies	36% ± 7%	Explore
OFF-bipolar cell	3 studies	27% ± 5%	Explore
ON-bipolar cell	3 studies	34% ± 6%	Explore
glycinergic amacrine cell	3 studies	35% ± 5%	Explore
rod bipolar cell	3 studies	41% ± 5%	Explore
mature NK T cell	3 studies	21% ± 7%	Explore
erythrocyte	3 studies	34% ± 14%	Explore
hematopoietic stem cell	3 studies	21% ± 3%	Explore
enterocyte	3 studies	18% ± 2%	Explore
adventitial cell	3 studies	26% ± 7%	Explore
alveolar macrophage	3 studies	30% ± 10%	Explore
chondrocyte	3 studies	40% ± 6%	Explore
Schwann cell	3 studies	35% ± 14%	Explore
transit amplifying cell	3 studies	37% ± 26%	Explore
brush cell	3 studies	23% ± 4%	Explore
granule cell	3 studies	37% ± 9%	Explore
hepatocyte	3 studies	56% ± 12%	Explore
mucus secreting cell	3 studies	27% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	42% ± 24%	Explore
lung	13 studies	29% ± 13%	Explore
eye	9 studies	33% ± 15%	Explore
intestine	6 studies	23% ± 12%	Explore
peripheral blood	5 studies	31% ± 9%	Explore
kidney	5 studies	23% ± 4%	Explore
heart	5 studies	24% ± 4%	Explore
uterus	3 studies	25% ± 11%	Explore
adipose	3 studies	33% ± 8%	Explore
liver	3 studies	40% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	7348.19	1445 / 1445	100%	50.80	183 / 183
prostate	100%	8751.57	245 / 245	100%	48.51	502 / 502
lung	100%	10932.52	578 / 578	100%	57.65	1154 / 1155
breast	100%	10749.43	459 / 459	100%	63.50	1117 / 1118
brain	100%	8949.39	2637 / 2642	100%	55.78	705 / 705
intestine	100%	10098.64	966 / 966	100%	35.86	526 / 527
ovary	100%	13358.73	180 / 180	100%	38.63	429 / 430
pancreas	100%	8668.39	328 / 328	99%	39.91	177 / 178
thymus	100%	11859.96	653 / 653	99%	47.08	601 / 605
kidney	100%	7324.79	89 / 89	99%	52.88	895 / 901
stomach	100%	8443.44	359 / 359	99%	36.87	284 / 286
bladder	100%	8469.62	21 / 21	99%	41.10	500 / 504
adrenal gland	100%	8006.61	258 / 258	99%	59.63	228 / 230
uterus	100%	11318.62	170 / 170	99%	45.25	455 / 459
skin	100%	10355.83	1809 / 1809	98%	40.14	461 / 472
liver	100%	4770.82	226 / 226	97%	27.67	393 / 406
adipose	100%	9415.47	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9029.42	1335 / 1335	0%	0	0 / 0
muscle	100%	11200.23	803 / 803	0%	0	0 / 0
spleen	100%	10205.63	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	36.59	45 / 45
ureter	0%	0	0 / 0	100%	23.81	1 / 1
heart	98%	6082.64	842 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	24.44	28 / 29
peripheral blood	96%	6250.19	890 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	91%	22.68	73 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_0036503	Biological process	ERAD pathway
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0010498	Biological process	proteasomal protein catabolic process
GO_0000835	Cellular component	ER ubiquitin ligase complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0019899	Molecular function	enzyme binding
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0031624	Molecular function	ubiquitin conjugating enzyme binding
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_1990381	Molecular function	ubiquitin-specific protease binding

IV. Literature review

[source]

Gene name	MARCHF6
Protein name	E3 ubiquitin-protein ligase MARCHF6 (EC 2.3.2.27) (Doa10 homolog) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) (Protein TEB-4) (RING finger protein 176) (RING-type E3 ubiquitin transferase MARCHF6) RING-type E3 ubiquitin transferase (EC 2.3.2.27)
Synonyms	KIAA0597 RNF176 TEB4 MARCH6
Description	FUNCTION: E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation . Promotes ubiquitination of DIO2, leading to its degradation . Promotes ubiquitination of SQLE, leading to its degradation . E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 . .
Accessions	ENST00000503788.5 [O60337-6] A0A0B4J206 ENST00000510792.1 ENST00000274140.10 [O60337-4] ENST00000449913.6 [O60337-5] ENST00000502795.5 O60337 D6RHY7

MARCHF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review