MAF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016480Biological processnegative regulation of transcription by RNA polymerase III
GO_0016479Biological processnegative regulation of transcription by RNA polymerase I
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0000994Molecular functionRNA polymerase III core binding
GO_0001002Molecular functionRNA polymerase III type 1 promoter sequence-specific DNA binding
GO_0001003Molecular functionRNA polymerase III type 2 promoter sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0001006Molecular functionRNA polymerase III type 3 promoter sequence-specific DNA binding

IV. Literature review

[source]
Gene nameMAF1
Protein nameRepressor of RNA polymerase III transcription MAF1 homolog
Repressor of RNA polymerase III transcription MAF1
Synonyms
DescriptionFUNCTION: Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance . Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB . When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout . Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP . .

FUNCTION: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. .

AccessionsENST00000322428.10
ENST00000527572.5
E9PJ05
ENST00000534585.5
ENST00000534811.1
H0YEV4
Q9H063
E9PSH4
E9PR76
ENST00000527058.1
ENST00000532522.5