LYST | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	30 studies	27% ± 9%	Explore
endothelial cell	25 studies	32% ± 16%	Explore
classical monocyte	25 studies	38% ± 15%	Explore
non-classical monocyte	24 studies	56% ± 15%	Explore
mast cell	20 studies	34% ± 15%	Explore
CD8-positive, alpha-beta T cell	19 studies	30% ± 11%	Explore
monocyte	18 studies	40% ± 17%	Explore
B cell	17 studies	28% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	30% ± 9%	Explore
astrocyte	16 studies	36% ± 20%	Explore
dendritic cell	16 studies	32% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	28% ± 8%	Explore
macrophage	15 studies	31% ± 13%	Explore
naive B cell	14 studies	26% ± 7%	Explore
microglial cell	13 studies	52% ± 18%	Explore
T cell	12 studies	23% ± 5%	Explore
glutamatergic neuron	11 studies	49% ± 25%	Explore
oligodendrocyte precursor cell	11 studies	32% ± 14%	Explore
myeloid cell	11 studies	32% ± 13%	Explore
conventional dendritic cell	10 studies	29% ± 21%	Explore
GABAergic neuron	10 studies	45% ± 23%	Explore
vein endothelial cell	10 studies	36% ± 22%	Explore
regulatory T cell	10 studies	22% ± 5%	Explore
oligodendrocyte	10 studies	28% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	28% ± 10%	Explore
mature NK T cell	9 studies	27% ± 10%	Explore
pericyte	9 studies	23% ± 8%	Explore
fibroblast	9 studies	30% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	28% ± 9%	Explore
retinal rod cell	8 studies	42% ± 22%	Explore
memory B cell	8 studies	19% ± 3%	Explore
gamma-delta T cell	8 studies	24% ± 6%	Explore
endothelial cell of lymphatic vessel	7 studies	33% ± 13%	Explore
neutrophil	7 studies	28% ± 6%	Explore
mucosal invariant T cell	7 studies	19% ± 3%	Explore
retinal cone cell	7 studies	44% ± 18%	Explore
interneuron	6 studies	54% ± 23%	Explore
epithelial cell	6 studies	32% ± 16%	Explore
ciliated cell	6 studies	25% ± 8%	Explore
type I pneumocyte	6 studies	22% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	23% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	21% ± 4%	Explore
neuron	5 studies	41% ± 15%	Explore
lymphocyte	5 studies	29% ± 12%	Explore
retina horizontal cell	5 studies	38% ± 20%	Explore
adipocyte	5 studies	22% ± 4%	Explore
amacrine cell	5 studies	36% ± 21%	Explore
double negative thymocyte	5 studies	36% ± 16%	Explore
endothelial cell of artery	5 studies	25% ± 6%	Explore
smooth muscle cell	5 studies	23% ± 4%	Explore
type II pneumocyte	5 studies	23% ± 4%	Explore
granule cell	4 studies	41% ± 5%	Explore
retinal ganglion cell	4 studies	37% ± 20%	Explore
retinal pigment epithelial cell	4 studies	35% ± 20%	Explore
mononuclear phagocyte	4 studies	34% ± 6%	Explore
Mueller cell	4 studies	35% ± 18%	Explore
abnormal cell	4 studies	21% ± 7%	Explore
alveolar macrophage	4 studies	45% ± 16%	Explore
leukocyte	3 studies	35% ± 14%	Explore
CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
exhausted T cell	3 studies	65% ± 8%	Explore
retinal bipolar neuron	3 studies	24% ± 9%	Explore
GABAergic interneuron	3 studies	40% ± 6%	Explore
progenitor cell	3 studies	25% ± 1%	Explore
OFF-bipolar cell	3 studies	46% ± 16%	Explore
ON-bipolar cell	3 studies	35% ± 14%	Explore
glycinergic amacrine cell	3 studies	34% ± 10%	Explore
intermediate monocyte	3 studies	54% ± 20%	Explore
innate lymphoid cell	3 studies	26% ± 4%	Explore
endothelial cell of vascular tree	3 studies	43% ± 15%	Explore
hepatocyte	3 studies	34% ± 14%	Explore
ependymal cell	3 studies	38% ± 17%	Explore
hematopoietic precursor cell	3 studies	39% ± 7%	Explore
Schwann cell	3 studies	37% ± 25%	Explore
melanocyte	3 studies	52% ± 27%	Explore
basal cell	3 studies	34% ± 26%	Explore
mural cell	3 studies	33% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	34% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	38% ± 21%	Explore
peripheral blood	15 studies	26% ± 9%	Explore
lung	8 studies	24% ± 7%	Explore
eye	8 studies	38% ± 21%	Explore
liver	5 studies	21% ± 8%	Explore
bone marrow	4 studies	21% ± 4%	Explore
heart	4 studies	20% ± 4%	Explore
adipose	4 studies	26% ± 5%	Explore
kidney	3 studies	26% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2874.62	1444 / 1445	99%	8.84	182 / 183
skin	100%	4953.36	1809 / 1809	99%	43.41	467 / 472
thymus	100%	3160.55	652 / 653	98%	10.70	592 / 605
brain	97%	2607.64	2561 / 2642	99%	8.47	699 / 705
breast	100%	5395.69	459 / 459	96%	9.57	1073 / 1118
lung	100%	5076.07	578 / 578	92%	5.93	1059 / 1155
uterus	100%	3770.57	170 / 170	84%	4.67	385 / 459
prostate	100%	2701.29	245 / 245	80%	3.34	400 / 502
pancreas	86%	981.23	281 / 328	93%	5.19	165 / 178
kidney	98%	1529.74	87 / 89	79%	4.67	711 / 901
bladder	100%	3637.52	21 / 21	75%	3.96	377 / 504
stomach	100%	2501.53	358 / 359	74%	3.91	213 / 286
adrenal gland	99%	1848.58	256 / 258	74%	3.73	171 / 230
intestine	100%	3022.09	966 / 966	60%	2.60	317 / 527
liver	97%	1261.33	219 / 226	57%	2.16	230 / 406
ovary	100%	2871.76	180 / 180	29%	0.85	125 / 430
adipose	100%	5202.47	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3481.41	1335 / 1335	0%	0	0 / 0
spleen	100%	5608.41	241 / 241	0%	0	0 / 0
peripheral blood	99%	6226.89	922 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	4.38	42 / 45
heart	87%	1221.17	751 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	79%	7.34	63 / 80
lymph node	0%	0	0 / 0	76%	6.61	22 / 29
muscle	76%	879.33	609 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0051607	Biological process	defense response to virus
GO_0033364	Biological process	mast cell secretory granule organization
GO_0015031	Biological process	protein transport
GO_0008104	Biological process	protein localization
GO_0042742	Biological process	defense response to bacterium
GO_0032510	Biological process	endosome to lysosome transport via multivesicular body sorting pathway
GO_0030595	Biological process	leukocyte chemotaxis
GO_0032438	Biological process	melanosome organization
GO_0043473	Biological process	pigmentation
GO_0006909	Biological process	phagocytosis
GO_0042832	Biological process	defense response to protozoan
GO_0042267	Biological process	natural killer cell mediated cytotoxicity
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0016020	Cellular component	membrane
GO_0019901	Molecular function	protein kinase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LYST
Protein name	LYST protein Lysosomal-trafficking regulator (Beige homolog) Lysosomal trafficking regulator
Synonyms	CHS1 CHS
Description	FUNCTION: Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes . Might regulate trafficking of effectors involved in exocytosis . In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules . In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways . .
Accessions	A0A8V8TKU7 A0A8V8TM69 ENST00000468626.2 A0A8V8TKT6 B7ZMN7 A0A8V8TL78 A0A8V8TME5 Q99698 ENST00000697235.1 A0A8V8TMC0 ENST00000487530.2 ENST00000697241.1 ENST00000697178.1 ENST00000697182.1 ENST00000489585.5 [Q99698-2] ENST00000697237.1 A0A8V8TM32 ENST00000697183.1 H7C4F5 A0A8V8TL83 A0A8V8TKS8 ENST00000389793.7 [Q99698-1] ENST00000468107.5 A0A8V8TL52 ENST00000697242.1 ENST00000697236.1 ENST00000475277.2 ENST00000697240.1 A0A8V8TMB4 ENST00000697184.1 ENST00000697180.1 ENST00000697181.1 A0A8V8TKW4 ENST00000461526.2 A0A8V8TL58

LYST report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review