Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 9 studies | 19% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 1225.78 | 578 / 578 | 90% | 9.55 | 1039 / 1155 |
thymus | 79% | 479.66 | 516 / 653 | 89% | 13.06 | 540 / 605 |
stomach | 88% | 516.73 | 317 / 359 | 68% | 8.41 | 195 / 286 |
uterus | 65% | 159.34 | 110 / 170 | 75% | 6.49 | 345 / 459 |
bladder | 57% | 528.52 | 12 / 21 | 81% | 8.06 | 409 / 504 |
esophagus | 59% | 213.61 | 854 / 1445 | 70% | 7.57 | 129 / 183 |
breast | 59% | 177.62 | 273 / 459 | 69% | 7.22 | 768 / 1118 |
intestine | 65% | 1576.45 | 632 / 966 | 61% | 5.16 | 320 / 527 |
prostate | 81% | 326.41 | 198 / 245 | 41% | 1.94 | 204 / 502 |
kidney | 51% | 272.69 | 45 / 89 | 58% | 4.21 | 520 / 901 |
liver | 81% | 231.70 | 184 / 226 | 24% | 1.61 | 97 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 103.07 | 29 / 29 |
spleen | 100% | 9835.21 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.22 | 1 / 1 |
peripheral blood | 99% | 5933.23 | 924 / 929 | 0% | 0 | 0 / 0 |
pancreas | 25% | 48.45 | 81 / 328 | 68% | 6.46 | 121 / 178 |
skin | 32% | 70.09 | 572 / 1809 | 59% | 8.98 | 277 / 472 |
tonsil | 0% | 0 | 0 / 0 | 89% | 17.92 | 40 / 45 |
adipose | 79% | 272.47 | 948 / 1204 | 0% | 0 | 0 / 0 |
ovary | 19% | 43.56 | 34 / 180 | 38% | 1.73 | 162 / 430 |
adrenal gland | 31% | 63.90 | 81 / 258 | 5% | 0.16 | 11 / 230 |
blood vessel | 33% | 121.75 | 447 / 1335 | 0% | 0 | 0 / 0 |
heart | 15% | 34.36 | 127 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 14% | 0.95 | 11 / 80 |
brain | 7% | 12.92 | 185 / 2642 | 3% | 0.31 | 23 / 705 |
muscle | 1% | 2.39 | 8 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045577 | Biological process | regulation of B cell differentiation |
GO_0007498 | Biological process | mesoderm development |
GO_0009617 | Biological process | response to bacterium |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0030888 | Biological process | regulation of B cell proliferation |
GO_0030217 | Biological process | T cell differentiation |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0045619 | Biological process | regulation of lymphocyte differentiation |
GO_0030183 | Biological process | B cell differentiation |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_1990841 | Molecular function | promoter-specific chromatin binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0043565 | Molecular function | sequence-specific DNA binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0005515 | Molecular function | protein binding |
GO_0042826 | Molecular function | histone deacetylase binding |
Gene name | IKZF3 |
Protein name | Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) IKAROS family zinc finger 3 |
Synonyms | ZNFN1A3 |
Description | FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. . |
Accessions | ENST00000351680.7 [Q9UKT9-3] ENST00000348427.7 Q9UKT9 ENST00000350532.7 [Q9UKT9-4] A0A0C4DGN9 ENST00000377958.6 [Q9UKT9-9] ENST00000377952.6 [Q9UKT9-12] ENST00000623724.3 [Q9UKT9-16] ENST00000439167.6 [Q9UKT9-8] ENST00000535189.5 [Q9UKT9-7] ENST00000377945.7 [Q9UKT9-13] ENST00000293068.9 [Q9UKT9-14] ENST00000439016.2 [Q9UKT9-5] ENST00000346243.7 [Q9UKT9-6] ENST00000583368.1 [Q9UKT9-16] ENST00000346872.8 [Q9UKT9-1] ENST00000467757.5 [Q9UKT9-2] ENST00000377944.7 [Q9UKT9-10] ENST00000394189.6 [Q9UKT9-11] |