HUWE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098779Biological processpositive regulation of mitophagy in response to mitochondrial depolarization
GO_0000209Biological processprotein polyubiquitination
GO_0061025Biological processmembrane fusion
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0006338Biological processchromatin remodeling
GO_0032922Biological processcircadian regulation of gene expression
GO_0007030Biological processGolgi organization
GO_0030154Biological processcell differentiation
GO_0010637Biological processnegative regulation of mitochondrial fusion
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0006284Biological processbase-excision repair
GO_0006513Biological processprotein monoubiquitination
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0034774Cellular componentsecretory granule lumen
GO_0000139Cellular componentGolgi membrane
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0140852Molecular functionhistone ubiquitin ligase activity
GO_0003723Molecular functionRNA binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHUWE1
Protein nameHUWE1 protein
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
HECT, UBA and WWE domain containing 1
Alternative protein HUWE1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
SynonymsRP3-339A18.4-002
RP3-339A18.4-010
KIAA0312
RP3-339A18.4-007
KIAA1578
HSPC272
UREB1
RP3-339A18.4-005
RP3-339A18.4-009
DescriptionFUNCTION: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins . Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 . Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair . Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 . Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC . Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination . Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN . May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation . Mediates polyubiquitination of isoform 2 of PA2G4 . Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 . Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling . .

AccessionsENST00000704099.1
Q5H963
Q5H964
ENST00000704101.1
Q8IWJ0
ENST00000468322.2
A0A994J483
Q7Z6Z7
A0A1B0GXC7
A0A087X146
ENST00000446750.1
ENST00000262854.11 [Q7Z6Z7-1]
ENST00000426907.5
A0A994J6V7
Q5H924
Q5H962
A0A087X1S3
Q3B7K0
A0A994J4V6
ENST00000612484.4 [Q7Z6Z7-3]
ENST00000622887.1
ENST00000704100.1
H0Y659
ENST00000342160.7 [Q7Z6Z7-1]
Q5H935
L8E996