HSPH1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	30 studies	35% ± 15%	Explore
macrophage	29 studies	42% ± 19%	Explore
natural killer cell	22 studies	33% ± 17%	Explore
CD4-positive, alpha-beta T cell	22 studies	32% ± 15%	Explore
mast cell	21 studies	37% ± 16%	Explore
fibroblast	21 studies	40% ± 18%	Explore
conventional dendritic cell	21 studies	36% ± 17%	Explore
CD8-positive, alpha-beta T cell	21 studies	33% ± 15%	Explore
B cell	19 studies	39% ± 15%	Explore
ciliated cell	18 studies	62% ± 19%	Explore
regulatory T cell	17 studies	31% ± 13%	Explore
T cell	16 studies	40% ± 20%	Explore
epithelial cell	16 studies	33% ± 17%	Explore
monocyte	15 studies	43% ± 19%	Explore
basal cell	15 studies	34% ± 13%	Explore
dendritic cell	14 studies	41% ± 23%	Explore
non-classical monocyte	14 studies	31% ± 14%	Explore
smooth muscle cell	14 studies	37% ± 15%	Explore
microglial cell	13 studies	27% ± 14%	Explore
astrocyte	12 studies	24% ± 6%	Explore
plasma cell	11 studies	32% ± 12%	Explore
classical monocyte	11 studies	26% ± 11%	Explore
memory B cell	11 studies	31% ± 10%	Explore
leukocyte	10 studies	41% ± 22%	Explore
connective tissue cell	10 studies	33% ± 11%	Explore
glutamatergic neuron	10 studies	47% ± 23%	Explore
pericyte	9 studies	42% ± 22%	Explore
naive B cell	9 studies	30% ± 12%	Explore
endothelial cell of vascular tree	9 studies	35% ± 14%	Explore
mature NK T cell	8 studies	28% ± 10%	Explore
abnormal cell	8 studies	27% ± 8%	Explore
secretory cell	8 studies	32% ± 10%	Explore
gamma-delta T cell	8 studies	40% ± 20%	Explore
plasmacytoid dendritic cell	8 studies	29% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	23% ± 8%	Explore
myeloid cell	7 studies	32% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	25% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	30% ± 13%	Explore
oligodendrocyte	7 studies	25% ± 9%	Explore
endothelial cell of lymphatic vessel	6 studies	32% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	20% ± 5%	Explore
capillary endothelial cell	6 studies	23% ± 8%	Explore
myofibroblast cell	6 studies	39% ± 18%	Explore
mucosal invariant T cell	6 studies	25% ± 10%	Explore
innate lymphoid cell	6 studies	33% ± 15%	Explore
GABAergic neuron	6 studies	46% ± 16%	Explore
alveolar macrophage	5 studies	27% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	20% ± 5%	Explore
mononuclear phagocyte	5 studies	32% ± 11%	Explore
plasmablast	5 studies	24% ± 5%	Explore
neuron	5 studies	31% ± 9%	Explore
retinal cone cell	5 studies	30% ± 15%	Explore
precursor B cell	5 studies	40% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	32% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	36% ± 16%	Explore
oligodendrocyte precursor cell	5 studies	21% ± 5%	Explore
type I pneumocyte	4 studies	27% ± 8%	Explore
type II pneumocyte	4 studies	27% ± 10%	Explore
deuterosomal cell	4 studies	54% ± 3%	Explore
ionocyte	4 studies	26% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	29% ± 10%	Explore
hematopoietic precursor cell	4 studies	21% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	31% ± 9%	Explore
retinal ganglion cell	4 studies	42% ± 20%	Explore
retinal pigment epithelial cell	4 studies	37% ± 19%	Explore
T follicular helper cell	4 studies	36% ± 13%	Explore
vein endothelial cell	4 studies	28% ± 12%	Explore
interneuron	4 studies	45% ± 21%	Explore
squamous epithelial cell	3 studies	39% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	45% ± 19%	Explore
glomerular endothelial cell	3 studies	46% ± 18%	Explore
epithelial cell of proximal tubule	3 studies	26% ± 9%	Explore
renal alpha-intercalated cell	3 studies	47% ± 23%	Explore
GABAergic interneuron	3 studies	23% ± 5%	Explore
glial cell	3 studies	25% ± 4%	Explore
ON-bipolar cell	3 studies	23% ± 5%	Explore
brush cell	3 studies	29% ± 14%	Explore
immature B cell	3 studies	43% ± 16%	Explore
amacrine cell	3 studies	25% ± 3%	Explore
retina horizontal cell	3 studies	23% ± 4%	Explore
tissue-resident macrophage	3 studies	35% ± 20%	Explore
erythroblast	3 studies	39% ± 3%	Explore
goblet cell	3 studies	21% ± 1%	Explore
intermediate monocyte	3 studies	34% ± 13%	Explore
CD4-positive helper T cell	3 studies	34% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	40% ± 3%	Explore
luminal cell of prostate epithelium	3 studies	44% ± 3%	Explore
ependymal cell	3 studies	37% ± 11%	Explore
enteroendocrine cell	3 studies	25% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	44% ± 18%	Explore
transit amplifying cell	3 studies	33% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	28% ± 11%	Explore
brain	15 studies	32% ± 18%	Explore
intestine	7 studies	27% ± 12%	Explore
kidney	6 studies	33% ± 8%	Explore
eye	6 studies	27% ± 15%	Explore
liver	5 studies	33% ± 8%	Explore
uterus	4 studies	36% ± 7%	Explore
lymph node	4 studies	26% ± 6%	Explore
peripheral blood	3 studies	20% ± 3%	Explore
skin	3 studies	25% ± 6%	Explore
thymus	3 studies	37% ± 21%	Explore
breast	3 studies	38% ± 2%	Explore
prostate	3 studies	54% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	6950.86	21 / 21	99%	74.33	499 / 504
esophagus	99%	4861.71	1436 / 1445	99%	93.11	182 / 183
uterus	99%	5200.98	168 / 170	99%	69.98	456 / 459
thymus	100%	6320.28	650 / 653	99%	45.69	596 / 605
stomach	98%	6237.43	353 / 359	99%	78.26	284 / 286
breast	98%	3597.35	448 / 459	100%	76.32	1116 / 1118
lung	98%	11226.96	566 / 578	99%	55.65	1145 / 1155
prostate	100%	4613.62	245 / 245	97%	35.40	487 / 502
brain	97%	12998.31	2571 / 2642	100%	46.42	702 / 705
ovary	99%	7086.97	179 / 180	97%	37.51	417 / 430
skin	98%	4044.17	1769 / 1809	98%	93.32	461 / 472
intestine	99%	4773.23	955 / 966	96%	84.34	507 / 527
adrenal gland	100%	6735.67	258 / 258	94%	57.46	217 / 230
kidney	99%	5975.02	88 / 89	85%	25.27	769 / 901
pancreas	84%	2291.20	276 / 328	99%	56.77	176 / 178
liver	77%	3374.52	173 / 226	73%	19.66	296 / 406
lymph node	0%	0	0 / 0	100%	75.03	29 / 29
tonsil	0%	0	0 / 0	100%	60.36	45 / 45
ureter	0%	0	0 / 0	100%	14.72	1 / 1
spleen	100%	4985.14	240 / 241	0%	0	0 / 0
blood vessel	99%	4804.66	1320 / 1335	0%	0	0 / 0
adipose	96%	5654.39	1161 / 1204	0%	0	0 / 0
muscle	94%	3688.06	753 / 803	0%	0	0 / 0
heart	91%	4990.73	781 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	81%	29.82	65 / 80
peripheral blood	61%	7327.53	571 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051135	Biological process	positive regulation of NK T cell activation
GO_0006986	Biological process	response to unfolded protein
GO_0045345	Biological process	positive regulation of MHC class I biosynthetic process
GO_0006457	Biological process	protein folding
GO_0051085	Biological process	chaperone cofactor-dependent protein refolding
GO_0005576	Cellular component	extracellular region
GO_0005874	Cellular component	microtubule
GO_0071682	Cellular component	endocytic vesicle lumen
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0000774	Molecular function	adenyl-nucleotide exchange factor activity
GO_0140662	Molecular function	ATP-dependent protein folding chaperone
GO_0043014	Molecular function	alpha-tubulin binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	HSPH1
Protein name	Heat shock protein family H (Hsp110) member 1 Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein)
Synonyms	HSP110 HSP105 KIAA0201
Description	FUNCTION: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release . Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). .
Accessions	ENST00000602786.5 ENST00000380405.7 [Q92598-2] A0A0A0MSM0 ENST00000320027.10 [Q92598-1] ENST00000435381.5 ENST00000630972.2 [Q92598-4] R4GN69 ENST00000445273.6 Q92598 Q5TBM3

HSPH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review