HECTD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0048856Biological processanatomical structure development
GO_0035904Biological processaorta development
GO_0003170Biological processheart valve development
GO_0003281Biological processventricular septum development
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0016607Cellular componentnuclear speck
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameHECTD1
Protein nameE3 ubiquitin-protein ligase (EC 2.3.2.26)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
HECT domain E3 ubiquitin protein ligase 1
SynonymshCG_1812148
KIAA1131
DescriptionFUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal . .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. .

AccessionsA0A8I5KU01
ENST00000553700.5
H0YJP0
Q9ULT8
H0YJD4
ENST00000399332.6
ENST00000554882.6
H0YJ72
G3V4V5
ENST00000692835.1
ENST00000691390.1
ENST00000556224.6
Q5XJ19
A0A087X2H1
ENST00000611816.5
A0A8I5QJU2
A0A8I5QJE9
ENST00000688933.1
Q9BRJ0
A0A8I5KUD6
ENST00000693685.1
ENST00000553957.6
ENST00000555915.1