GNAI3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007194Biological processnegative regulation of adenylate cyclase activity
GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0046039Biological processGTP metabolic process
GO_0051301Biological processcell division
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0016239Biological processpositive regulation of macroautophagy
GO_0007212Biological processG protein-coupled dopamine receptor signaling pathway
GO_0005730Cellular componentnucleolus
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0000139Cellular componentGolgi membrane
GO_0005737Cellular componentcytoplasm
GO_0005834Cellular componentheterotrimeric G-protein complex
GO_0005765Cellular componentlysosomal membrane
GO_0019003Molecular functionGDP binding
GO_0031683Molecular functionG-protein beta/gamma-subunit complex binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0005525Molecular functionGTP binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGNAI3
Protein nameGuanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)
Synonyms
DescriptionFUNCTION: Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins . Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels . Stimulates the activity of receptor-regulated K(+) channels . The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division . .

AccessionsP08754
ENST00000369851.7