FERMT3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	31 studies	30% ± 12%	Explore
natural killer cell	26 studies	26% ± 7%	Explore
classical monocyte	23 studies	41% ± 14%	Explore
conventional dendritic cell	22 studies	32% ± 18%	Explore
non-classical monocyte	22 studies	34% ± 14%	Explore
CD8-positive, alpha-beta T cell	22 studies	26% ± 7%	Explore
monocyte	19 studies	30% ± 10%	Explore
plasmacytoid dendritic cell	19 studies	48% ± 12%	Explore
CD4-positive, alpha-beta T cell	19 studies	22% ± 6%	Explore
regulatory T cell	16 studies	25% ± 5%	Explore
B cell	15 studies	22% ± 6%	Explore
T cell	14 studies	23% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	32% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	27% ± 7%	Explore
mature NK T cell	13 studies	27% ± 7%	Explore
myeloid cell	13 studies	35% ± 13%	Explore
dendritic cell	11 studies	35% ± 20%	Explore
platelet	11 studies	58% ± 18%	Explore
gamma-delta T cell	11 studies	28% ± 11%	Explore
memory B cell	9 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	23% ± 5%	Explore
mucosal invariant T cell	9 studies	25% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	26% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	29% ± 9%	Explore
naive B cell	8 studies	19% ± 6%	Explore
alveolar macrophage	7 studies	21% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	30% ± 5%	Explore
hematopoietic precursor cell	6 studies	34% ± 16%	Explore
plasma cell	6 studies	32% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	19% ± 2%	Explore
megakaryocyte	6 studies	79% ± 17%	Explore
hematopoietic stem cell	6 studies	39% ± 22%	Explore
plasmablast	5 studies	39% ± 20%	Explore
T follicular helper cell	5 studies	19% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	30% ± 12%	Explore
mast cell	4 studies	22% ± 8%	Explore
neutrophil	4 studies	22% ± 2%	Explore
exhausted T cell	4 studies	32% ± 9%	Explore
immature B cell	4 studies	22% ± 8%	Explore
microglial cell	4 studies	21% ± 5%	Explore
mononuclear phagocyte	4 studies	31% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	33% ± 5%	Explore
intermediate monocyte	4 studies	45% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	29% ± 5%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	56% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	26% ± 7%	Explore
leukocyte	3 studies	24% ± 6%	Explore
innate lymphoid cell	3 studies	25% ± 6%	Explore
precursor B cell	3 studies	34% ± 6%	Explore
pro-B cell	3 studies	30% ± 8%	Explore
germinal center B cell	3 studies	33% ± 9%	Explore
T-helper 17 cell	3 studies	20% ± 2%	Explore
T-helper 1 cell	3 studies	26% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	26% ± 4%	Explore
double negative thymocyte	3 studies	31% ± 5%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	29% ± 4%	Explore
erythrocyte	3 studies	24% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	29% ± 12%	Explore
lung	3 studies	25% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4529.11	578 / 578	95%	35.79	1099 / 1155
breast	95%	1215.78	436 / 459	93%	27.01	1035 / 1118
intestine	94%	1599.48	904 / 966	88%	28.59	463 / 527
stomach	92%	1122.53	330 / 359	88%	32.35	251 / 286
bladder	100%	1029.33	21 / 21	74%	24.29	374 / 504
uterus	85%	659.88	145 / 170	86%	20.72	395 / 459
thymus	91%	968.88	596 / 653	80%	35.13	481 / 605
kidney	76%	805.07	68 / 89	87%	26.22	784 / 901
esophagus	73%	615.71	1052 / 1445	79%	18.44	144 / 183
prostate	86%	733.04	210 / 245	66%	9.39	330 / 502
skin	59%	414.95	1073 / 1809	91%	65.71	430 / 472
adrenal gland	95%	1192.78	244 / 258	51%	8.05	117 / 230
ovary	42%	312.62	76 / 180	81%	17.95	349 / 430
liver	57%	466.18	128 / 226	64%	13.04	260 / 406
pancreas	26%	182.80	84 / 328	95%	56.13	169 / 178
brain	26%	196.85	691 / 2642	88%	25.54	618 / 705
lymph node	0%	0	0 / 0	100%	368.31	29 / 29
peripheral blood	100%	19741.44	929 / 929	0%	0	0 / 0
spleen	100%	11674.89	241 / 241	0%	0	0 / 0
adipose	100%	2249.65	1200 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	42.68	42 / 45
eye	0%	0	0 / 0	89%	119.79	71 / 80
blood vessel	85%	1259.14	1139 / 1335	0%	0	0 / 0
heart	66%	526.38	565 / 861	0%	0	0 / 0
muscle	18%	102.77	142 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0033632	Biological process	regulation of cell-cell adhesion mediated by integrin
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0033622	Biological process	integrin activation
GO_0034446	Biological process	substrate adhesion-dependent cell spreading
GO_0030335	Biological process	positive regulation of cell migration
GO_0007159	Biological process	leukocyte cell-cell adhesion
GO_0070527	Biological process	platelet aggregation
GO_0007160	Biological process	cell-matrix adhesion
GO_0042995	Cellular component	cell projection
GO_0002102	Cellular component	podosome
GO_0030055	Cellular component	cell-substrate junction
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0016020	Cellular component	membrane
GO_0008289	Molecular function	lipid binding
GO_0005178	Molecular function	integrin binding

IV. Literature review

[source]

Gene name	FERMT3
Protein name	FERM domain containing kindlin 3 Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) Fermitin family homolog 3
Synonyms	KIND3 URP2 MIG2B
Description	FUNCTION: Plays a central role in cell adhesion in hematopoietic cells . Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells . Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). .; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. .
Accessions	A0A8V8TME2 Q86UX7 ENST00000545896.2 F5H1C6 A0A8V8TP46 ENST00000279227.10 [Q86UX7-1] A0A8V8TMT7 A0A8V8TP41 A0A8V8TNT4 ENST00000698854.1 ENST00000544997.6 [Q86UX7-2] ENST00000698845.1 ENST00000698860.1 [Q86UX7-1] ENST00000698866.1 A0A8V8TMS8 ENST00000698873.1 ENST00000698847.1 ENST00000345728.10 [Q86UX7-2] H0YFT5 ENST00000698872.1 F5H3I6 ENST00000541252.2 ENST00000698869.1 ENST00000698852.1 [Q86UX7-2] A0A8V8TMB3 ENST00000698870.1 [Q86UX7-2] ENST00000698853.1 ENST00000698862.1 ENST00000698874.1 ENST00000698861.1 [Q86UX7-2] ENST00000698878.1 ENST00000698880.1 ENST00000698879.1 ENST00000698865.1 ENST00000544997.5 ENST00000698863.1 [Q86UX7-2] A0A8V8TMT4 A0A8V8TMD7 A0A8V8TNT9 ENST00000698868.1 A0A8V8TMU1

FERMT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review