FDPS | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	38 studies	35% ± 13%	Explore
natural killer cell	26 studies	24% ± 9%	Explore
endothelial cell of lymphatic vessel	23 studies	42% ± 15%	Explore
T cell	16 studies	22% ± 6%	Explore
epithelial cell	16 studies	35% ± 19%	Explore
B cell	15 studies	20% ± 7%	Explore
fibroblast	15 studies	26% ± 10%	Explore
basal cell	13 studies	33% ± 18%	Explore
CD8-positive, alpha-beta T cell	13 studies	33% ± 17%	Explore
capillary endothelial cell	13 studies	38% ± 13%	Explore
gamma-delta T cell	13 studies	23% ± 14%	Explore
type II pneumocyte	12 studies	39% ± 17%	Explore
endothelial cell of artery	12 studies	42% ± 16%	Explore
pericyte	12 studies	22% ± 6%	Explore
vein endothelial cell	12 studies	31% ± 14%	Explore
endothelial cell of vascular tree	12 studies	26% ± 8%	Explore
plasma cell	11 studies	36% ± 13%	Explore
CD4-positive, alpha-beta T cell	11 studies	33% ± 21%	Explore
smooth muscle cell	11 studies	23% ± 5%	Explore
type I pneumocyte	10 studies	24% ± 11%	Explore
club cell	10 studies	28% ± 13%	Explore
astrocyte	10 studies	27% ± 10%	Explore
regulatory T cell	10 studies	29% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	23% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	24% ± 5%	Explore
ciliated cell	9 studies	35% ± 12%	Explore
plasmablast	8 studies	42% ± 21%	Explore
secretory cell	8 studies	33% ± 19%	Explore
mature NK T cell	8 studies	21% ± 5%	Explore
connective tissue cell	8 studies	26% ± 8%	Explore
goblet cell	8 studies	32% ± 16%	Explore
myofibroblast cell	7 studies	22% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	26% ± 12%	Explore
conventional dendritic cell	6 studies	30% ± 16%	Explore
enterocyte	6 studies	23% ± 4%	Explore
transit amplifying cell	6 studies	27% ± 9%	Explore
neuron	6 studies	34% ± 12%	Explore
abnormal cell	6 studies	35% ± 12%	Explore
oligodendrocyte precursor cell	6 studies	26% ± 10%	Explore
plasmacytoid dendritic cell	6 studies	23% ± 6%	Explore
hematopoietic precursor cell	5 studies	39% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 5%	Explore
progenitor cell	5 studies	27% ± 7%	Explore
epithelial cell of proximal tubule	5 studies	19% ± 5%	Explore
amacrine cell	5 studies	34% ± 7%	Explore
retinal ganglion cell	5 studies	75% ± 25%	Explore
mucus secreting cell	5 studies	27% ± 3%	Explore
adipocyte	5 studies	30% ± 20%	Explore
dendritic cell	5 studies	35% ± 15%	Explore
macrophage	5 studies	22% ± 5%	Explore
hepatocyte	5 studies	44% ± 27%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	31% ± 15%	Explore
duct epithelial cell	4 studies	34% ± 6%	Explore
ionocyte	4 studies	30% ± 4%	Explore
respiratory goblet cell	4 studies	35% ± 17%	Explore
pancreatic A cell	4 studies	30% ± 7%	Explore
exhausted T cell	4 studies	31% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	27% ± 12%	Explore
non-classical monocyte	4 studies	31% ± 9%	Explore
kidney loop of Henle epithelial cell	4 studies	18% ± 2%	Explore
mesothelial cell	4 studies	26% ± 13%	Explore
erythroblast	4 studies	40% ± 22%	Explore
lymphocyte	4 studies	31% ± 11%	Explore
precursor B cell	4 studies	27% ± 9%	Explore
monocyte	4 studies	27% ± 3%	Explore
erythrocyte	4 studies	36% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	33% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	48% ± 18%	Explore
GABAergic neuron	4 studies	34% ± 13%	Explore
glutamatergic neuron	4 studies	44% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	31% ± 18%	Explore
enteroendocrine cell	4 studies	36% ± 15%	Explore
oligodendrocyte	4 studies	28% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	18% ± 3%	Explore
memory B cell	4 studies	25% ± 14%	Explore
mucosal invariant T cell	4 studies	17% ± 2%	Explore
type B pancreatic cell	3 studies	33% ± 1%	Explore
leukocyte	3 studies	23% ± 10%	Explore
classical monocyte	3 studies	32% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	19% ± 4%	Explore
glomerular endothelial cell	3 studies	33% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	28% ± 9%	Explore
neural crest cell	3 studies	30% ± 5%	Explore
GABAergic amacrine cell	3 studies	25% ± 11%	Explore
pro-B cell	3 studies	25% ± 1%	Explore
retina horizontal cell	3 studies	27% ± 9%	Explore
retinal cone cell	3 studies	32% ± 6%	Explore
retinal rod cell	3 studies	22% ± 3%	Explore
serous secreting cell	3 studies	25% ± 5%	Explore
Mueller cell	3 studies	23% ± 5%	Explore
germinal center B cell	3 studies	19% ± 5%	Explore
endothelial cell of sinusoid	3 studies	24% ± 4%	Explore
granulocyte monocyte progenitor cell	3 studies	47% ± 25%	Explore
hematopoietic stem cell	3 studies	32% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	48% ± 17%	Explore
innate lymphoid cell	3 studies	18% ± 2%	Explore
double negative thymocyte	3 studies	31% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	26% ± 11%	Explore
peripheral blood	9 studies	23% ± 9%	Explore
intestine	8 studies	22% ± 8%	Explore
liver	8 studies	31% ± 20%	Explore
kidney	7 studies	19% ± 3%	Explore
eye	7 studies	24% ± 7%	Explore
brain	7 studies	27% ± 12%	Explore
pancreas	4 studies	30% ± 7%	Explore
adrenal gland	3 studies	18% ± 3%	Explore
bone marrow	3 studies	23% ± 8%	Explore
breast	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	1544.29	180 / 180	100%	42.63	430 / 430
stomach	100%	1979.09	359 / 359	100%	39.97	286 / 286
esophagus	100%	2368.90	1443 / 1445	100%	27.74	183 / 183
intestine	100%	2214.45	966 / 966	100%	50.06	526 / 527
lung	100%	3006.68	578 / 578	100%	39.02	1152 / 1155
breast	100%	2210.92	459 / 459	99%	37.64	1112 / 1118
pancreas	100%	1405.24	328 / 328	99%	33.13	177 / 178
uterus	100%	1831.33	170 / 170	99%	42.90	456 / 459
skin	100%	2993.29	1809 / 1809	99%	35.90	468 / 472
brain	99%	1458.29	2615 / 2642	100%	31.57	704 / 705
liver	100%	3268.50	226 / 226	99%	60.70	401 / 406
bladder	100%	1429.95	21 / 21	98%	40.43	496 / 504
prostate	100%	1536.39	245 / 245	98%	23.86	492 / 502
thymus	100%	1719.00	653 / 653	97%	22.03	585 / 605
kidney	100%	1797.51	89 / 89	93%	19.33	835 / 901
adrenal gland	100%	5447.22	258 / 258	89%	40.38	205 / 230
adipose	100%	2248.22	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	43.37	29 / 29
spleen	100%	1981.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	41.93	45 / 45
blood vessel	100%	1605.90	1331 / 1335	0%	0	0 / 0
muscle	99%	999.29	795 / 803	0%	0	0 / 0
heart	98%	1295.50	843 / 861	0%	0	0 / 0
peripheral blood	95%	2602.39	886 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	95%	17.74	76 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006695	Biological process	cholesterol biosynthetic process
GO_0045337	Biological process	farnesyl diphosphate biosynthetic process
GO_0033384	Biological process	geranyl diphosphate biosynthetic process
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0004161	Molecular function	dimethylallyltranstransferase activity
GO_0004337	Molecular function	geranyltranstransferase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	FDPS
Protein name	Farnesyl pyrophosphate synthase ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (Farnesyl diphosphate synthase) (Geranyltranstransferase) Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase) Alternative protein FDPS (2E,6E)-farnesyl diphosphate synthase (Dimethylallyltranstransferase) (Farnesyl diphosphate synthase) (Geranyltranstransferase) Farnesyl diphosphate synthase
Synonyms	KIAA1293 FPS hCG_1997329
Description	FUNCTION: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Accessions	A0A087X090 ENST00000611010.4 A0A087X1D8 A0A087WVN4 ENST00000474345.5 ENST00000491013.5 ENST00000447866.5 [P14324-2] P14324 A0A087WTP2 ENST00000356657.10 [P14324-1] ENST00000467076.5 [P14324-2] L8EC92 ENST00000465559.5 ENST00000368356.9 [P14324-1] ENST00000612683.1 [P14324-2]

FDPS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review