ERP44 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	33 studies	28% ± 11%	Explore
endothelial cell	27 studies	25% ± 9%	Explore
fibroblast	24 studies	24% ± 10%	Explore
natural killer cell	21 studies	21% ± 5%	Explore
non-classical monocyte	20 studies	30% ± 13%	Explore
classical monocyte	20 studies	25% ± 10%	Explore
monocyte	18 studies	23% ± 6%	Explore
B cell	18 studies	22% ± 6%	Explore
conventional dendritic cell	15 studies	28% ± 14%	Explore
pericyte	14 studies	23% ± 7%	Explore
naive B cell	13 studies	20% ± 5%	Explore
endothelial cell of lymphatic vessel	12 studies	22% ± 7%	Explore
CD8-positive, alpha-beta T cell	11 studies	21% ± 4%	Explore
mature NK T cell	11 studies	18% ± 3%	Explore
microglial cell	11 studies	29% ± 9%	Explore
myeloid cell	11 studies	26% ± 10%	Explore
plasma cell	10 studies	36% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	20% ± 4%	Explore
regulatory T cell	10 studies	18% ± 3%	Explore
dendritic cell	10 studies	29% ± 19%	Explore
gamma-delta T cell	10 studies	21% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	22% ± 4%	Explore
connective tissue cell	9 studies	22% ± 6%	Explore
plasmacytoid dendritic cell	9 studies	25% ± 8%	Explore
alveolar macrophage	8 studies	26% ± 7%	Explore
plasmablast	8 studies	40% ± 25%	Explore
CD4-positive, alpha-beta T cell	8 studies	20% ± 5%	Explore
smooth muscle cell	8 studies	20% ± 5%	Explore
mucosal invariant T cell	8 studies	18% ± 2%	Explore
epithelial cell	8 studies	41% ± 20%	Explore
T cell	8 studies	19% ± 3%	Explore
memory B cell	8 studies	18% ± 3%	Explore
capillary endothelial cell	7 studies	18% ± 3%	Explore
myofibroblast cell	7 studies	19% ± 3%	Explore
glutamatergic neuron	7 studies	42% ± 26%	Explore
ciliated cell	7 studies	27% ± 6%	Explore
type I pneumocyte	7 studies	23% ± 7%	Explore
oligodendrocyte	7 studies	27% ± 9%	Explore
endothelial cell of vascular tree	6 studies	21% ± 4%	Explore
GABAergic neuron	6 studies	41% ± 21%	Explore
astrocyte	6 studies	34% ± 14%	Explore
goblet cell	6 studies	31% ± 17%	Explore
basal cell	6 studies	32% ± 12%	Explore
mononuclear phagocyte	5 studies	33% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
endothelial cell of artery	5 studies	18% ± 4%	Explore
innate lymphoid cell	5 studies	19% ± 1%	Explore
type II pneumocyte	5 studies	24% ± 12%	Explore
secretory cell	4 studies	23% ± 7%	Explore
hematopoietic precursor cell	4 studies	27% ± 9%	Explore
neuron	4 studies	31% ± 10%	Explore
enterocyte	4 studies	19% ± 2%	Explore
immature B cell	4 studies	24% ± 5%	Explore
vein endothelial cell	4 studies	21% ± 5%	Explore
lymphocyte	4 studies	24% ± 6%	Explore
oligodendrocyte precursor cell	4 studies	31% ± 8%	Explore
abnormal cell	4 studies	22% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	23% ± 7%	Explore
interneuron	4 studies	46% ± 24%	Explore
mast cell	4 studies	19% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	18% ± 3%	Explore
pancreatic A cell	3 studies	42% ± 8%	Explore
type B pancreatic cell	3 studies	47% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
exhausted T cell	3 studies	24% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
progenitor cell	3 studies	15% ± 0%	Explore
GABAergic interneuron	3 studies	19% ± 3%	Explore
extravillous trophoblast	3 studies	25% ± 4%	Explore
placental villous trophoblast	3 studies	28% ± 3%	Explore
pro-B cell	3 studies	22% ± 2%	Explore
tissue-resident macrophage	3 studies	27% ± 6%	Explore
germinal center B cell	3 studies	21% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	22% ± 7%	Explore
pancreatic ductal cell	3 studies	41% ± 17%	Explore
enteroendocrine cell	3 studies	26% ± 10%	Explore
intestinal crypt stem cell	3 studies	21% ± 4%	Explore
leukocyte	3 studies	24% ± 3%	Explore
club cell	3 studies	25% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 7%	Explore
transit amplifying cell	3 studies	24% ± 9%	Explore
adipocyte	3 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	19% ± 3%	Explore
double negative thymocyte	3 studies	28% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	23% ± 7%	Explore
brain	10 studies	35% ± 18%	Explore
lung	9 studies	27% ± 6%	Explore
intestine	5 studies	22% ± 10%	Explore
pancreas	3 studies	44% ± 9%	Explore
placenta	3 studies	25% ± 3%	Explore
bone marrow	3 studies	16% ± 1%	Explore
adipose	3 studies	18% ± 1%	Explore
liver	3 studies	32% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3088.44	1445 / 1445	100%	67.31	183 / 183
liver	100%	3413.17	226 / 226	100%	50.68	406 / 406
lung	100%	4233.07	578 / 578	100%	58.80	1155 / 1155
ovary	100%	2791.99	180 / 180	100%	60.19	430 / 430
pancreas	100%	3517.12	328 / 328	100%	56.63	178 / 178
prostate	100%	2955.66	245 / 245	100%	78.57	502 / 502
stomach	100%	3345.91	359 / 359	100%	66.85	286 / 286
uterus	100%	3259.00	170 / 170	100%	62.61	459 / 459
breast	100%	3693.70	459 / 459	100%	54.51	1117 / 1118
thymus	100%	4457.25	653 / 653	100%	67.31	604 / 605
intestine	100%	3395.80	966 / 966	100%	67.55	526 / 527
bladder	100%	3222.00	21 / 21	100%	58.20	503 / 504
skin	100%	3532.11	1809 / 1809	100%	49.18	471 / 472
kidney	100%	2767.42	89 / 89	100%	47.21	898 / 901
adrenal gland	100%	3455.20	258 / 258	100%	55.24	229 / 230
brain	98%	1543.66	2593 / 2642	100%	34.71	705 / 705
adipose	100%	3959.76	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3740.24	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	86.11	29 / 29
spleen	100%	3556.58	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	55.97	45 / 45
ureter	0%	0	0 / 0	100%	26.38	1 / 1
peripheral blood	99%	4145.94	923 / 929	0%	0	0 / 0
muscle	99%	1651.79	797 / 803	0%	0	0 / 0
heart	99%	2411.78	849 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	33.92	76 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045454	Biological process	cell redox homeostasis
GO_0006457	Biological process	protein folding
GO_0006986	Biological process	response to unfolded protein
GO_0009100	Biological process	glycoprotein metabolic process
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0009986	Cellular component	cell surface
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0070062	Cellular component	extracellular exosome
GO_0005576	Cellular component	extracellular region
GO_0035580	Cellular component	specific granule lumen
GO_0005793	Cellular component	endoplasmic reticulum-Golgi intermediate compartment
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0003756	Molecular function	protein disulfide isomerase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ERP44
Protein name	Alternative protein ERP44 Endoplasmic reticulum protein 44 Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4)
Synonyms	UNQ532/PRO1075 TXNDC4 KIAA0573
Description	FUNCTION: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif . Inhibits the calcium channel activity of ITPR1 . May have a role in the control of oxidative protein folding in the endoplasmic reticulum . Required to retain ERO1A and ERO1B in the endoplasmic reticulum . .
Accessions	ENST00000689406.1 ENST00000687017.1 L8EAR9 A0A8I5KY49 ENST00000690317.1 A0A8I5KYU2 ENST00000687025.1 ENST00000686275.1 A0A8I5KW59 ENST00000691188.1 ENST00000262455.7 ENST00000687093.1 A0A8I5KNC9 Q9BS26 A0A8I5KT21 A0A8I5KTR3 A0A8I5KVZ0 ENST00000684842.1 ENST00000688230.1 A0A8I5KU76 ENST00000690739.1

ERP44 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review