BAZ2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016479Biological processnegative regulation of transcription by RNA polymerase I
GO_0000183Biological processrDNA heterochromatin formation
GO_0006346Biological processDNA methylation-dependent heterochromatin formation
GO_0006338Biological processchromatin remodeling
GO_0031507Biological processheterochromatin formation
GO_0006351Biological processDNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001188Biological processRNA polymerase I preinitiation complex assembly
GO_0005730Cellular componentnucleolus
GO_0016607Cellular componentnuclear speck
GO_0005677Cellular componentchromatin silencing complex
GO_0090536Cellular componentNoRC complex
GO_0005829Cellular componentcytosol
GO_0033553Cellular componentrDNA heterochromatin
GO_0005634Cellular componentnucleus
GO_0016922Molecular functionnuclear receptor binding
GO_0042393Molecular functionhistone binding
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0046872Molecular functionmetal ion binding
GO_0001164Molecular functionRNA polymerase I core promoter sequence-specific DNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBAZ2A
Protein nameBromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3)
Bromodomain adjacent to zinc finger domain 2A
SynonymsTIP5
KIAA0314
DescriptionFUNCTION: Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair . Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template . Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex . The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex . Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). .

AccessionsJ3KPG5
Q9UIF9
H0YHQ7
ENST00000551996.1
F8VU39
A0A0C4DGI9
ENST00000549787.5
H0YII3
ENST00000549884.6
ENST00000379441.7
F8VWQ3
ENST00000546695.5
F8W053
ENST00000551812.5 [Q9UIF9-1]
ENST00000549506.5
H0YHL2
ENST00000547650.1
ENST00000547453.1