ATP6V0D1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0097401Biological processsynaptic vesicle lumen acidification
GO_0036295Biological processcellular response to increased oxygen levels
GO_0006879Biological processintracellular iron ion homeostasis
GO_0007035Biological processvacuolar acidification
GO_0016241Biological processregulation of macroautophagy
GO_0007034Biological processvacuolar transport
GO_1902600Biological processproton transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0005813Cellular componentcentrosome
GO_1902495Cellular componenttransmembrane transporter complex
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0043679Cellular componentaxon terminus
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0000220Cellular componentvacuolar proton-transporting V-type ATPase, V0 domain
GO_0010008Cellular componentendosome membrane
GO_0016471Cellular componentvacuolar proton-transporting V-type ATPase complex
GO_0005765Cellular componentlysosomal membrane
GO_0033181Cellular componentplasma membrane proton-transporting V-type ATPase complex
GO_0030665Cellular componentclathrin-coated vesicle membrane
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0044877Molecular functionprotein-containing complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATP6V0D1
Protein nameV-type proton ATPase subunit
ATPase H+ transporting V0 subunit D1
V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1)
ATPase H+ transporting V0 subunit d1
SynonymsVPATPD
ATP6D
DescriptionFUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment . May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation . May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). .

FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. .

AccessionsH3BUQ0
H3BQJ1
H3BTB4
ENST00000568101.5
H3BTB5
F8WEN9
ENST00000564615.5
J3QL14
F5GYQ1
P61421
ENST00000290949.8
ENST00000561852.5
H3BSG7
ENST00000426604.7
ENST00000565835.5
ENST00000564191.5
C6SUN6
ENST00000563064.5
ENST00000540149.5
ENST00000566322.6
H3BQB4
ENST00000564788.1
H3BPS0