ATP2B1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	39 studies	35% ± 13%	Explore
B cell	37 studies	35% ± 11%	Explore
endothelial cell	26 studies	31% ± 15%	Explore
conventional dendritic cell	25 studies	37% ± 12%	Explore
non-classical monocyte	24 studies	40% ± 16%	Explore
classical monocyte	24 studies	42% ± 14%	Explore
fibroblast	21 studies	25% ± 9%	Explore
monocyte	20 studies	42% ± 17%	Explore
memory B cell	20 studies	36% ± 11%	Explore
dendritic cell	18 studies	44% ± 15%	Explore
CD4-positive, alpha-beta T cell	18 studies	23% ± 5%	Explore
naive B cell	17 studies	31% ± 9%	Explore
T cell	16 studies	24% ± 9%	Explore
oligodendrocyte precursor cell	15 studies	38% ± 16%	Explore
natural killer cell	14 studies	23% ± 5%	Explore
regulatory T cell	14 studies	24% ± 7%	Explore
glutamatergic neuron	13 studies	72% ± 23%	Explore
myeloid cell	12 studies	37% ± 18%	Explore
endothelial cell of lymphatic vessel	11 studies	27% ± 8%	Explore
GABAergic neuron	11 studies	51% ± 24%	Explore
astrocyte	11 studies	29% ± 13%	Explore
microglial cell	11 studies	39% ± 8%	Explore
neutrophil	10 studies	34% ± 12%	Explore
leukocyte	10 studies	29% ± 6%	Explore
CD8-positive, alpha-beta T cell	10 studies	20% ± 6%	Explore
epithelial cell	10 studies	40% ± 22%	Explore
pericyte	10 studies	26% ± 7%	Explore
oligodendrocyte	10 studies	31% ± 12%	Explore
connective tissue cell	9 studies	31% ± 8%	Explore
neuron	9 studies	44% ± 20%	Explore
alveolar macrophage	8 studies	31% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	21% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	24% ± 8%	Explore
mesothelial cell	8 studies	46% ± 16%	Explore
smooth muscle cell	8 studies	19% ± 3%	Explore
mucosal invariant T cell	8 studies	20% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	22% ± 4%	Explore
mononuclear phagocyte	7 studies	43% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	21% ± 5%	Explore
myofibroblast cell	7 studies	29% ± 10%	Explore
amacrine cell	7 studies	35% ± 13%	Explore
interneuron	7 studies	52% ± 21%	Explore
retinal cone cell	7 studies	63% ± 17%	Explore
retinal rod cell	7 studies	32% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 4%	Explore
gamma-delta T cell	7 studies	22% ± 5%	Explore
secretory cell	6 studies	20% ± 6%	Explore
mature NK T cell	6 studies	22% ± 6%	Explore
vein endothelial cell	6 studies	31% ± 12%	Explore
retinal ganglion cell	6 studies	43% ± 18%	Explore
lymphocyte	6 studies	30% ± 9%	Explore
retina horizontal cell	6 studies	52% ± 14%	Explore
basal cell	6 studies	27% ± 8%	Explore
endothelial cell of vascular tree	6 studies	21% ± 7%	Explore
progenitor cell	5 studies	30% ± 12%	Explore
abnormal cell	5 studies	41% ± 15%	Explore
endothelial cell of artery	5 studies	23% ± 5%	Explore
enteroendocrine cell	5 studies	33% ± 11%	Explore
retinal bipolar neuron	5 studies	70% ± 17%	Explore
ON-bipolar cell	5 studies	60% ± 28%	Explore
Mueller cell	5 studies	26% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	27% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	22% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	21% ± 3%	Explore
enterocyte	4 studies	24% ± 4%	Explore
glial cell	4 studies	30% ± 13%	Explore
granule cell	4 studies	61% ± 13%	Explore
immature B cell	4 studies	29% ± 4%	Explore
ciliated cell	4 studies	24% ± 5%	Explore
OFF-bipolar cell	4 studies	40% ± 14%	Explore
myoepithelial cell	4 studies	33% ± 6%	Explore
type II pneumocyte	4 studies	24% ± 5%	Explore
pancreatic A cell	3 studies	60% ± 8%	Explore
type B pancreatic cell	3 studies	40% ± 11%	Explore
monocyte-derived dendritic cell	3 studies	47% ± 14%	Explore
hematopoietic precursor cell	3 studies	38% ± 17%	Explore
plasmablast	3 studies	33% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	17% ± 2%	Explore
neural crest cell	3 studies	26% ± 9%	Explore
GABAergic interneuron	3 studies	51% ± 6%	Explore
innate lymphoid cell	3 studies	30% ± 8%	Explore
plasma cell	3 studies	27% ± 11%	Explore
tissue-resident macrophage	3 studies	40% ± 13%	Explore
GABAergic amacrine cell	3 studies	31% ± 9%	Explore
rod bipolar cell	3 studies	74% ± 1%	Explore
intermediate monocyte	3 studies	58% ± 13%	Explore
CD4-positive helper T cell	3 studies	29% ± 7%	Explore
type I pneumocyte	3 studies	20% ± 1%	Explore
ependymal cell	3 studies	32% ± 9%	Explore
hematopoietic stem cell	3 studies	22% ± 4%	Explore
mast cell	3 studies	26% ± 8%	Explore
T follicular helper cell	3 studies	18% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	32% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	45% ± 22%	Explore
peripheral blood	14 studies	26% ± 9%	Explore
lung	12 studies	27% ± 8%	Explore
eye	10 studies	34% ± 10%	Explore
intestine	8 studies	24% ± 9%	Explore
liver	5 studies	28% ± 13%	Explore
kidney	4 studies	22% ± 9%	Explore
adipose	4 studies	29% ± 6%	Explore
pancreas	3 studies	46% ± 8%	Explore
bone marrow	3 studies	29% ± 11%	Explore
uterus	3 studies	23% ± 9%	Explore
placenta	3 studies	29% ± 3%	Explore
lymph node	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	11423.50	2586 / 2642	100%	32.15	702 / 705
bladder	100%	3034.62	21 / 21	97%	22.99	491 / 504
lung	99%	3379.76	572 / 578	98%	29.35	1137 / 1155
intestine	100%	3267.04	966 / 966	97%	21.24	513 / 527
ovary	98%	2518.80	176 / 180	99%	22.92	425 / 430
prostate	98%	2159.05	239 / 245	98%	19.02	491 / 502
uterus	99%	2512.70	168 / 170	96%	22.96	440 / 459
breast	97%	2377.20	447 / 459	97%	22.69	1087 / 1118
esophagus	94%	1784.14	1362 / 1445	100%	36.14	183 / 183
thymus	99%	2285.09	645 / 653	95%	13.82	572 / 605
stomach	95%	1718.61	342 / 359	97%	21.90	278 / 286
skin	100%	7317.81	1801 / 1809	90%	28.18	423 / 472
pancreas	82%	1242.94	268 / 328	98%	20.45	175 / 178
kidney	79%	1420.93	70 / 89	95%	16.58	855 / 901
adrenal gland	72%	1081.54	185 / 258	94%	21.97	216 / 230
liver	68%	1004.80	154 / 226	77%	9.64	311 / 406
spleen	100%	3663.17	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	6.29	1 / 1
adipose	99%	3241.69	1196 / 1204	0%	0	0 / 0
muscle	99%	2562.23	791 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	24.07	28 / 29
blood vessel	94%	1817.78	1250 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	19.27	42 / 45
peripheral blood	77%	3046.78	715 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	54%	5.74	43 / 80
heart	49%	710.86	425 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051480	Biological process	regulation of cytosolic calcium ion concentration
GO_0008217	Biological process	regulation of blood pressure
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0001818	Biological process	negative regulation of cytokine production
GO_0051928	Biological process	positive regulation of calcium ion transport
GO_0003056	Biological process	regulation of vascular associated smooth muscle contraction
GO_1903779	Biological process	regulation of cardiac conduction
GO_1990034	Biological process	calcium ion export across plasma membrane
GO_1900076	Biological process	regulation of cellular response to insulin stimulus
GO_0030501	Biological process	positive regulation of bone mineralization
GO_0051481	Biological process	negative regulation of cytosolic calcium ion concentration
GO_0001772	Cellular component	immunological synapse
GO_0098978	Cellular component	glutamatergic synapse
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0042734	Cellular component	presynaptic membrane
GO_0098684	Cellular component	photoreceptor ribbon synapse
GO_0042995	Cellular component	cell projection
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0016323	Cellular component	basolateral plasma membrane
GO_0015085	Molecular function	calcium ion transmembrane transporter activity
GO_0005388	Molecular function	P-type calcium transporter activity
GO_0030165	Molecular function	PDZ domain binding
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0005516	Molecular function	calmodulin binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	ATP2B1
Protein name	ATPase plasma membrane Ca2+ transporting 1 Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) PMCA1kb Plasma membrane calcium-transporting ATPase 1 (Plasma membrane calcium ATPase isoform 1) (Plasma membrane calcium pump isoform 1) Plasma membrane calcium-ATPase isoform 1b
Synonyms	PMCA1
Description	FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis . Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells . May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. .
Accessions	Q3L582 ENST00000705822.1 [P20020-5] F8W1V5 ENST00000550716.1 Q58F24 ENST00000428670.8 [P20020-3] ENST00000705786.1 ENST00000359142.8 [P20020-2] A1X4P7 H0YHH6 ENST00000551310.2 A0A0U1RQU3 P20020 A0A994J4Z0 ENST00000635033.1 ENST00000551310.2 [P20020-2]

ATP2B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review