AP2B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035904Biological processaorta development
GO_0098884Biological processpostsynaptic neurotransmitter receptor internalization
GO_0048488Biological processsynaptic vesicle endocytosis
GO_0001822Biological processkidney development
GO_0006886Biological processintracellular protein transport
GO_0060976Biological processcoronary vasculature development
GO_0003281Biological processventricular septum development
GO_0016192Biological processvesicle-mediated transport
GO_0072583Biological processclathrin-dependent endocytosis
GO_0098978Cellular componentglutamatergic synapse
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0030122Cellular componentAP-2 adaptor complex
GO_0016020Cellular componentmembrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0098794Cellular componentpostsynapse
GO_0030131Cellular componentclathrin adaptor complex
GO_0005829Cellular componentcytosol
GO_0045334Cellular componentclathrin-coated endocytic vesicle
GO_0036020Cellular componentendolysosome membrane
GO_0005048Molecular functionsignal sequence binding
GO_0035615Molecular functionclathrin adaptor activity
GO_0030276Molecular functionclathrin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAP2B1
Protein nameAdaptor related protein complex 2 subunit beta 1
AP complex subunit beta
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
SynonymsCLAPB1
ADTB2
hCG_1992160
DescriptionFUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 . The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. .

AccessionsENST00000612035.4
ENST00000620039.4
K7EKZ5
P63010
A0A140VJE8
K7EN71
ENST00000614600.4
ENST00000590432.5
A0A087WU93
A0A087WXS3
A0A087WYD1
ENST00000610402.5 [P63010-2]
ENST00000621914.4 [P63010-1]
ENST00000612116.5
ENST00000587805.1
A0A087WZQ6
K7ERB2
K7EJX1
ENST00000593014.3
K7EMN7
ENST00000618940.4 [P63010-2]
K7EJ01
A0A087X253
ENST00000616681.4
ENST00000628168.1
ENST00000588116.1
ENST00000592167.5
ENST00000591610.5
ENST00000589774.5
ENST00000590538.5
ENST00000616784.4
ENST00000621668.4