AKNA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001837Biological processepithelial to mesenchymal transition
GO_0021849Biological processneuroblast division in subventricular zone
GO_0050727Biological processregulation of inflammatory response
GO_0060232Biological processdelamination
GO_0060234Biological processneuroblast delamination
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005814Cellular componentcentriole
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005874Cellular componentmicrotubule
GO_0001650Cellular componentfibrillar center
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAKNA
Protein nameAKNA transcript C1
AKNA transcript B1
Microtubule organization protein AKNA (AT-hook-containing transcription factor)
AKNA transcript C2
AKNA transcript F2
SynonymsKIAA1968
DescriptionFUNCTION: Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development . Binds to A/T-rich promoters . It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). .

AccessionsQ7Z591
ENST00000374088.8 [Q7Z591-1]
Q64FY1
ENST00000312033.3 [Q7Z591-3]
ENST00000307564.8 [Q7Z591-1]
Q64FX5
Q64FX9
ENST00000374079.8 [Q7Z591-4]
ENST00000223791.7 [Q7Z591-8]
Q64FY0
ENST00000374075.9 [Q7Z591-2]