AFF4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	43 studies	35% ± 15%	Explore
fibroblast	36 studies	31% ± 13%	Explore
macrophage	31 studies	30% ± 13%	Explore
pericyte	28 studies	30% ± 12%	Explore
B cell	25 studies	25% ± 8%	Explore
smooth muscle cell	24 studies	29% ± 9%	Explore
natural killer cell	21 studies	22% ± 5%	Explore
classical monocyte	17 studies	25% ± 9%	Explore
naive B cell	17 studies	26% ± 8%	Explore
astrocyte	17 studies	38% ± 15%	Explore
epithelial cell	15 studies	37% ± 22%	Explore
CD4-positive, alpha-beta T cell	15 studies	20% ± 5%	Explore
CD8-positive, alpha-beta T cell	14 studies	20% ± 4%	Explore
microglial cell	14 studies	36% ± 14%	Explore
memory B cell	14 studies	23% ± 5%	Explore
basal cell	13 studies	33% ± 18%	Explore
non-classical monocyte	13 studies	25% ± 10%	Explore
oligodendrocyte precursor cell	13 studies	36% ± 15%	Explore
oligodendrocyte	13 studies	36% ± 12%	Explore
T cell	12 studies	24% ± 7%	Explore
monocyte	12 studies	29% ± 9%	Explore
ciliated cell	12 studies	26% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	23% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	24% ± 7%	Explore
capillary endothelial cell	12 studies	22% ± 5%	Explore
myofibroblast cell	12 studies	28% ± 10%	Explore
mast cell	11 studies	27% ± 9%	Explore
endothelial cell of lymphatic vessel	11 studies	29% ± 11%	Explore
plasmacytoid dendritic cell	11 studies	28% ± 9%	Explore
glutamatergic neuron	11 studies	47% ± 26%	Explore
connective tissue cell	11 studies	26% ± 9%	Explore
dendritic cell	10 studies	29% ± 16%	Explore
type I pneumocyte	10 studies	33% ± 9%	Explore
conventional dendritic cell	10 studies	30% ± 13%	Explore
endothelial cell of artery	10 studies	23% ± 7%	Explore
adipocyte	10 studies	35% ± 10%	Explore
GABAergic neuron	9 studies	46% ± 24%	Explore
neuron	9 studies	40% ± 18%	Explore
myeloid cell	9 studies	38% ± 9%	Explore
endothelial cell of vascular tree	9 studies	28% ± 16%	Explore
regulatory T cell	9 studies	19% ± 3%	Explore
gamma-delta T cell	9 studies	24% ± 9%	Explore
type II pneumocyte	8 studies	32% ± 8%	Explore
club cell	8 studies	31% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	21% ± 6%	Explore
mature NK T cell	8 studies	21% ± 5%	Explore
abnormal cell	8 studies	34% ± 16%	Explore
retinal rod cell	8 studies	30% ± 10%	Explore
vein endothelial cell	8 studies	31% ± 18%	Explore
secretory cell	7 studies	25% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	20% ± 5%	Explore
interneuron	7 studies	45% ± 23%	Explore
retinal cone cell	7 studies	33% ± 8%	Explore
goblet cell	7 studies	32% ± 26%	Explore
respiratory goblet cell	6 studies	33% ± 10%	Explore
retinal ganglion cell	6 studies	28% ± 12%	Explore
mucosal invariant T cell	6 studies	20% ± 4%	Explore
amacrine cell	6 studies	30% ± 11%	Explore
retina horizontal cell	6 studies	30% ± 9%	Explore
Mueller cell	6 studies	37% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	22% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	21% ± 5%	Explore
mononuclear phagocyte	5 studies	25% ± 10%	Explore
progenitor cell	5 studies	27% ± 3%	Explore
retinal bipolar neuron	5 studies	21% ± 3%	Explore
precursor B cell	5 studies	30% ± 9%	Explore
cardiac muscle cell	5 studies	33% ± 10%	Explore
mesothelial cell	5 studies	30% ± 9%	Explore
lymphocyte	5 studies	33% ± 9%	Explore
T follicular helper cell	5 studies	21% ± 4%	Explore
leukocyte	5 studies	23% ± 4%	Explore
squamous epithelial cell	4 studies	47% ± 17%	Explore
pancreatic A cell	4 studies	38% ± 20%	Explore
glial cell	4 studies	26% ± 5%	Explore
granule cell	4 studies	31% ± 5%	Explore
pro-B cell	4 studies	23% ± 2%	Explore
plasma cell	4 studies	30% ± 9%	Explore
brush cell	4 studies	29% ± 7%	Explore
immature B cell	4 studies	32% ± 10%	Explore
retinal pigment epithelial cell	4 studies	45% ± 25%	Explore
innate lymphoid cell	4 studies	21% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 6%	Explore
hepatocyte	4 studies	49% ± 22%	Explore
muscle cell	4 studies	39% ± 22%	Explore
enteroendocrine cell	4 studies	26% ± 5%	Explore
alveolar macrophage	4 studies	38% ± 14%	Explore
ionocyte	3 studies	41% ± 8%	Explore
type B pancreatic cell	3 studies	44% ± 28%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	24% ± 5%	Explore
plasmablast	3 studies	42% ± 11%	Explore
glomerular endothelial cell	3 studies	22% ± 3%	Explore
renal alpha-intercalated cell	3 studies	22% ± 6%	Explore
GABAergic interneuron	3 studies	35% ± 3%	Explore
kidney loop of Henle epithelial cell	3 studies	21% ± 0%	Explore
tissue-resident macrophage	3 studies	31% ± 11%	Explore
GABAergic amacrine cell	3 studies	33% ± 11%	Explore
OFF-bipolar cell	3 studies	27% ± 5%	Explore
ON-bipolar cell	3 studies	26% ± 8%	Explore
glycinergic amacrine cell	3 studies	32% ± 7%	Explore
rod bipolar cell	3 studies	33% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 6%	Explore
neural progenitor cell	3 studies	31% ± 10%	Explore
ependymal cell	3 studies	42% ± 13%	Explore
adventitial cell	3 studies	29% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 7%	Explore
Schwann cell	3 studies	27% ± 10%	Explore
myoepithelial cell	3 studies	34% ± 11%	Explore
epithelial cell of proximal tubule	3 studies	19% ± 5%	Explore
mucus secreting cell	3 studies	28% ± 6%	Explore
renal principal cell	3 studies	24% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	40% ± 20%	Explore
lung	13 studies	27% ± 7%	Explore
peripheral blood	10 studies	25% ± 10%	Explore
eye	10 studies	33% ± 17%	Explore
kidney	6 studies	24% ± 4%	Explore
breast	5 studies	20% ± 6%	Explore
intestine	5 studies	22% ± 6%	Explore
heart	4 studies	31% ± 8%	Explore
adipose	4 studies	36% ± 10%	Explore
pancreas	3 studies	43% ± 22%	Explore
uterus	3 studies	33% ± 14%	Explore
lymph node	3 studies	25% ± 6%	Explore
liver	3 studies	35% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	8223.18	1445 / 1445	100%	45.31	183 / 183
lung	100%	9259.29	578 / 578	100%	31.89	1150 / 1155
ovary	100%	10971.75	180 / 180	99%	23.16	427 / 430
prostate	100%	8138.38	245 / 245	99%	43.85	497 / 502
brain	99%	5157.18	2620 / 2642	100%	42.60	703 / 705
breast	100%	8853.52	459 / 459	99%	56.10	1105 / 1118
pancreas	100%	3775.57	328 / 328	98%	35.50	175 / 178
adrenal gland	100%	9050.29	258 / 258	98%	37.19	225 / 230
kidney	100%	5288.20	89 / 89	98%	43.86	880 / 901
thymus	100%	9180.07	653 / 653	98%	40.75	590 / 605
stomach	100%	6193.51	359 / 359	97%	30.44	276 / 286
uterus	100%	9079.16	170 / 170	96%	25.80	442 / 459
liver	100%	5168.92	226 / 226	96%	21.74	390 / 406
bladder	100%	8440.05	21 / 21	96%	24.12	483 / 504
intestine	100%	7500.17	966 / 966	95%	24.99	503 / 527
skin	100%	9165.93	1809 / 1809	95%	36.10	449 / 472
adipose	100%	8803.65	1204 / 1204	0%	0	0 / 0
blood vessel	100%	10616.04	1335 / 1335	0%	0	0 / 0
muscle	100%	6606.87	803 / 803	0%	0	0 / 0
spleen	100%	4836.18	241 / 241	0%	0	0 / 0
heart	96%	4492.01	826 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	26.02	43 / 45
eye	0%	0	0 / 0	83%	18.25	66 / 80
peripheral blood	66%	2328.08	612 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	62%	11.62	18 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

IV. Literature review

[source]

Gene name	AFF4
Protein name	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) ALF transcription elongation factor 4 Alternative protein AFF4 AFF4 protein
Synonyms	MCEF HSPC092 AF5Q31
Description	FUNCTION: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. .
Accessions	ENST00000421773.1 C9JCE0 ENST00000425658.1 Q9UHB7 H7C319 ENST00000378595.7 [Q9UHB7-2] Q8TAX5 L8E815 ENST00000265343.10 [Q9UHB7-1]

GO_0010468	Biological process	regulation of gene expression
GO_0007286	Biological process	spermatid development
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0032783	Cellular component	super elongation complex
GO_0000791	Cellular component	euchromatin
GO_0005654	Cellular component	nucleoplasm
GO_0008023	Cellular component	transcription elongation factor complex
GO_0001650	Cellular component	fibrillar center
GO_0005515	Molecular function	protein binding

AFF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review