ADH5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045777Biological processpositive regulation of blood pressure
GO_0046294Biological processformaldehyde catabolic process
GO_0051409Biological processresponse to nitrosative stress
GO_0010430Biological processfatty acid omega-oxidation
GO_0001523Biological processretinoid metabolic process
GO_0051775Biological processresponse to redox state
GO_0003016Biological processrespiratory system process
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0106322Molecular functionS-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity
GO_0009055Molecular functionelectron transfer activity
GO_0004024Molecular functionalcohol dehydrogenase (NAD+) activity, zinc-dependent
GO_0042802Molecular functionidentical protein binding
GO_0106321Molecular functionS-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity
GO_0051903Molecular functionS-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
GO_0005504Molecular functionfatty acid binding
GO_0008270Molecular functionzinc ion binding
GO_0018467Molecular functionformaldehyde dehydrogenase (NAD+) activity

IV. Literature review

[source]
Gene nameADH5
Protein nameAlcohol dehydrogenase class-3 (Alcohol dehydrogenase class-III)
Alcohol dehydrogenase 5 (EC 1.1.1.1)
S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284)
Alcohol dehydrogenase class-3
Alcohol dehydrogenase 5 (class III), chi polypeptide
Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284)
SynonymsFDH
hCG_41483
HEL-S-60p
ADHX
DescriptionFUNCTION: Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione . Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate . Class-III ADH is remarkably ineffective in oxidizing ethanol . Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage . .

AccessionsD6R9G2
D6RAY0
ENST00000512659.5
D6RFE4
ENST00000296412.14
ENST00000505652.1
H0YAG8
Q6FI45
ENST00000502590.5
Q9H1A0
P11766
Q6IRT1
ENST00000503130.5
ENST00000626055.2