ZFAND3 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
endothelial cell	31 studies	54% ± 22%	Explore
macrophage	20 studies	50% ± 27%	Explore
astrocyte	19 studies	61% ± 19%	Explore
fibroblast	18 studies	48% ± 21%	Explore
microglial cell	16 studies	71% ± 14%	Explore
oligodendrocyte	15 studies	54% ± 14%	Explore
smooth muscle cell	14 studies	46% ± 18%	Explore
oligodendrocyte precursor cell	14 studies	59% ± 18%	Explore
pericyte	14 studies	50% ± 22%	Explore
glutamatergic neuron	12 studies	69% ± 20%	Explore
GABAergic neuron	11 studies	64% ± 20%	Explore
adipocyte	11 studies	62% ± 21%	Explore
natural killer cell	10 studies	34% ± 20%	Explore
mast cell	10 studies	44% ± 18%	Explore
myeloid cell	9 studies	51% ± 21%	Explore
dendritic cell	9 studies	49% ± 21%	Explore
mesothelial cell	9 studies	49% ± 17%	Explore
endothelial cell of lymphatic vessel	9 studies	55% ± 21%	Explore
classical monocyte	8 studies	22% ± 6%	Explore
epithelial cell	8 studies	54% ± 17%	Explore
ciliated cell	8 studies	40% ± 18%	Explore
T cell	8 studies	40% ± 20%	Explore
monocyte	7 studies	60% ± 28%	Explore
neuron	7 studies	59% ± 25%	Explore
B cell	7 studies	45% ± 16%	Explore
basal cell	7 studies	52% ± 22%	Explore
interneuron	6 studies	74% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	30% ± 16%	Explore
retinal cone cell	6 studies	59% ± 30%	Explore
capillary endothelial cell	6 studies	38% ± 23%	Explore
vein endothelial cell	6 studies	49% ± 26%	Explore
type I pneumocyte	6 studies	59% ± 19%	Explore
type II pneumocyte	6 studies	62% ± 18%	Explore
non-classical monocyte	5 studies	27% ± 9%	Explore
leukocyte	5 studies	62% ± 18%	Explore
myofibroblast cell	5 studies	38% ± 26%	Explore
amacrine cell	5 studies	62% ± 27%	Explore
retina horizontal cell	5 studies	59% ± 25%	Explore
cardiac muscle cell	5 studies	62% ± 14%	Explore
endothelial cell of artery	5 studies	42% ± 20%	Explore
club cell	5 studies	55% ± 21%	Explore
regulatory T cell	5 studies	32% ± 14%	Explore
cholangiocyte	4 studies	64% ± 20%	Explore
hepatocyte	4 studies	73% ± 22%	Explore
glial cell	4 studies	39% ± 12%	Explore
granule cell	4 studies	67% ± 8%	Explore
plasma cell	4 studies	45% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	30% ± 13%	Explore
retinal pigment epithelial cell	4 studies	58% ± 26%	Explore
CD4-positive, alpha-beta T cell	4 studies	38% ± 9%	Explore
CD8-positive, alpha-beta T cell	4 studies	35% ± 14%	Explore
lymphocyte	4 studies	45% ± 21%	Explore
Mueller cell	4 studies	63% ± 18%	Explore
retinal ganglion cell	4 studies	65% ± 21%	Explore
retinal rod cell	4 studies	70% ± 14%	Explore
muscle cell	4 studies	50% ± 29%	Explore
alveolar macrophage	4 studies	65% ± 28%	Explore
naive B cell	4 studies	17% ± 2%	Explore
squamous epithelial cell	3 studies	45% ± 19%	Explore
pancreatic A cell	3 studies	28% ± 9%	Explore
endothelial cell of sinusoid	3 studies	36% ± 12%	Explore
hepatic stellate cell	3 studies	59% ± 23%	Explore
conventional dendritic cell	3 studies	24% ± 3%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	61% ± 3%	Explore
GABAergic interneuron	3 studies	63% ± 5%	Explore
progenitor cell	3 studies	49% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	36% ± 12%	Explore
mononuclear phagocyte	3 studies	49% ± 22%	Explore
mucosal invariant T cell	3 studies	35% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	32% ± 14%	Explore
GABAergic amacrine cell	3 studies	69% ± 14%	Explore
OFF-bipolar cell	3 studies	59% ± 25%	Explore
ON-bipolar cell	3 studies	59% ± 26%	Explore
glycinergic amacrine cell	3 studies	61% ± 14%	Explore
endothelial cell of vascular tree	3 studies	62% ± 15%	Explore
mature NK T cell	3 studies	35% ± 24%	Explore
connective tissue cell	3 studies	48% ± 19%	Explore
ependymal cell	3 studies	70% ± 13%	Explore
megakaryocyte	3 studies	40% ± 23%	Explore
neutrophil	3 studies	44% ± 20%	Explore
respiratory goblet cell	3 studies	60% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	22% ± 6%	Explore
mural cell	3 studies	64% ± 5%	Explore
mucus secreting cell	3 studies	55% ± 10%	Explore
gamma-delta T cell	3 studies	20% ± 3%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
brain	18 studies	60% ± 21%	Explore
lung	7 studies	49% ± 18%	Explore
eye	6 studies	61% ± 23%	Explore
heart	6 studies	45% ± 20%	Explore
liver	3 studies	54% ± 19%	Explore
peripheral blood	3 studies	19% ± 2%	Explore
intestine	3 studies	18% ± 2%	Explore
adipose	3 studies	61% ± 25%	Explore
kidney	3 studies	59% ± 10%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5048.08	1445 / 1445	100%	61.15	183 / 183
stomach	100%	4047.54	359 / 359	100%	62.96	286 / 286
brain	100%	4113.50	2640 / 2642	100%	140.86	705 / 705
prostate	100%	4519.70	245 / 245	100%	82.04	501 / 502
ovary	100%	3650.79	180 / 180	100%	79.82	429 / 430
skin	100%	4281.55	1808 / 1809	100%	103.60	471 / 472
breast	100%	4465.72	459 / 459	100%	94.84	1115 / 1118
intestine	100%	4994.65	966 / 966	100%	62.24	525 / 527
lung	100%	4727.77	577 / 578	100%	74.91	1152 / 1155
thymus	100%	4464.04	652 / 653	100%	91.89	602 / 605
kidney	100%	4405.11	89 / 89	99%	80.42	894 / 901
bladder	100%	5534.33	21 / 21	99%	67.74	500 / 504
pancreas	100%	2378.68	328 / 328	99%	69.40	176 / 178
liver	100%	3403.46	225 / 226	99%	70.15	402 / 406
uterus	100%	4283.06	170 / 170	98%	71.95	452 / 459
adrenal gland	100%	4678.86	258 / 258	98%	91.86	225 / 230
adipose	100%	4902.84	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6425.59	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	101.85	80 / 80
lymph node	0%	0	0 / 0	100%	51.84	29 / 29
muscle	100%	7598.22	803 / 803	0%	0	0 / 0
spleen	100%	3396.36	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	60.15	45 / 45
ureter	0%	0	0 / 0	100%	39.03	1 / 1
peripheral blood	99%	5347.19	924 / 929	0%	0	0 / 0
heart	98%	3676.04	841 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0