XPO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032434Biological processregulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006611Biological processprotein export from nucleus
GO_0000054Biological processribosomal subunit export from nucleus
GO_0042254Biological processribosome biogenesis
GO_0006406Biological processmRNA export from nucleus
GO_0010824Biological processregulation of centrosome duplication
GO_0034504Biological processprotein localization to nucleus
GO_0000056Biological processribosomal small subunit export from nucleus
GO_0006913Biological processnucleocytoplasmic transport
GO_0046825Biological processregulation of protein export from nucleus
GO_0000055Biological processribosomal large subunit export from nucleus
GO_0005730Cellular componentnucleolus
GO_0016020Cellular componentmembrane
GO_0005642Cellular componentannulate lamellae
GO_0000776Cellular componentkinetochore
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005635Cellular componentnuclear envelope
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0015030Cellular componentCajal body
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_1990904Cellular componentribonucleoprotein complex
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0031267Molecular functionsmall GTPase binding
GO_0003723Molecular functionRNA binding
GO_0005049Molecular functionnuclear export signal receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameXPO1
Protein nameExportin 1
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
SynonymsCRM1
DescriptionFUNCTION: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. .; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. .

AccessionsA0A7I2YQV4
ENST00000401558.7
ENST00000677803.1
ENST00000404992.6
ENST00000676999.1
ENST00000679035.1
ENST00000677814.1
A0A7I2V3W6
O14980
ENST00000677289.1
A0A7I2V2S3
ENST00000677813.1
ENST00000678263.1
ENST00000677150.1
ENST00000678182.1
ENST00000677476.1
ENST00000680228.1
ENST00000677850.1
ENST00000451765.6
A0A7I2V396
ENST00000676667.1
A0A7I2YQX3
A0A7I2V3P3
F8WF71
ENST00000677239.1
A0A7I2V3J1
ENST00000676789.1
A0A7I2V461
ENST00000676783.1
ENST00000678081.1
ENST00000677556.1
ENST00000678877.1
ENST00000443240.5
A0A7I2V2C5
A0A7I2V488
ENST00000678741.1
A0A7I2YQP1
A0A7I2V3N0
C9IYM2
ENST00000677928.1
A0A7I2V6B9
A0A7I2V2Y6
ENST00000676771.1
A0A7I2V4A3
ENST00000449444.5
ENST00000406957.5
ENST00000677933.1
ENST00000678790.1
ENST00000677417.1
ENST00000678172.1
ENST00000678360.1
A0A7P0Z4B7
A0A7I2V531
C9JKM9
ENST00000676889.1
ENST00000677422.1
ENST00000428210.5
ENST00000676553.1
A0A7I2V2H0
C9J673