WAPL | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	20 studies	24% ± 8%	Explore
macrophage	18 studies	25% ± 11%	Explore
natural killer cell	14 studies	19% ± 3%	Explore
classical monocyte	10 studies	21% ± 7%	Explore
regulatory T cell	10 studies	20% ± 4%	Explore
fibroblast	10 studies	21% ± 6%	Explore
CD8-positive, alpha-beta T cell	9 studies	19% ± 3%	Explore
oligodendrocyte	9 studies	28% ± 10%	Explore
T cell	8 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	8 studies	19% ± 4%	Explore
plasmacytoid dendritic cell	8 studies	22% ± 7%	Explore
myeloid cell	8 studies	26% ± 6%	Explore
epithelial cell	8 studies	34% ± 18%	Explore
dendritic cell	8 studies	29% ± 13%	Explore
gamma-delta T cell	8 studies	22% ± 9%	Explore
astrocyte	8 studies	29% ± 11%	Explore
microglial cell	8 studies	34% ± 11%	Explore
type I pneumocyte	7 studies	24% ± 6%	Explore
non-classical monocyte	7 studies	22% ± 7%	Explore
retinal rod cell	7 studies	29% ± 12%	Explore
monocyte	7 studies	25% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	20% ± 3%	Explore
pericyte	7 studies	21% ± 8%	Explore
oligodendrocyte precursor cell	7 studies	26% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	18% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	18% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	19% ± 2%	Explore
conventional dendritic cell	6 studies	26% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	19% ± 2%	Explore
mature NK T cell	6 studies	18% ± 3%	Explore
mucosal invariant T cell	6 studies	20% ± 3%	Explore
basal cell	6 studies	26% ± 13%	Explore
type II pneumocyte	6 studies	21% ± 6%	Explore
B cell	5 studies	17% ± 1%	Explore
leukocyte	5 studies	24% ± 7%	Explore
naive B cell	5 studies	17% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	18% ± 3%	Explore
glutamatergic neuron	5 studies	44% ± 22%	Explore
adipocyte	5 studies	23% ± 3%	Explore
GABAergic neuron	5 studies	37% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	19% ± 4%	Explore
neuron	4 studies	27% ± 11%	Explore
retina horizontal cell	4 studies	21% ± 6%	Explore
ciliated cell	4 studies	29% ± 9%	Explore
lymphocyte	4 studies	28% ± 8%	Explore
abnormal cell	4 studies	24% ± 11%	Explore
club cell	4 studies	22% ± 6%	Explore
alveolar macrophage	4 studies	27% ± 11%	Explore
endothelial cell of lymphatic vessel	4 studies	26% ± 7%	Explore
smooth muscle cell	4 studies	19% ± 2%	Explore
goblet cell	4 studies	30% ± 21%	Explore
interneuron	4 studies	38% ± 22%	Explore
exhausted T cell	3 studies	21% ± 6%	Explore
hematopoietic precursor cell	3 studies	29% ± 4%	Explore
glomerular endothelial cell	3 studies	19% ± 0%	Explore
retinal cone cell	3 studies	23% ± 1%	Explore
rod bipolar cell	3 studies	19% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	19% ± 3%	Explore
innate lymphoid cell	3 studies	19% ± 3%	Explore
memory B cell	3 studies	18% ± 3%	Explore
hepatocyte	3 studies	40% ± 21%	Explore
muscle cell	3 studies	26% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	26% ± 12%	Explore
myofibroblast cell	3 studies	19% ± 4%	Explore
T follicular helper cell	3 studies	18% ± 0%	Explore
transit amplifying cell	3 studies	35% ± 21%	Explore
mast cell	3 studies	21% ± 4%	Explore
erythroblast	3 studies	26% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	33% ± 17%	Explore
peripheral blood	8 studies	20% ± 4%	Explore
eye	6 studies	29% ± 13%	Explore
lung	4 studies	23% ± 5%	Explore
liver	4 studies	32% ± 10%	Explore
adipose	4 studies	19% ± 2%	Explore
kidney	3 studies	17% ± 2%	Explore
intestine	3 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	3374.29	459 / 459	100%	46.54	1118 / 1118
esophagus	100%	3166.50	1445 / 1445	100%	35.41	183 / 183
intestine	100%	3247.37	966 / 966	100%	29.07	527 / 527
lung	100%	3500.08	578 / 578	100%	29.37	1155 / 1155
stomach	100%	2463.34	359 / 359	100%	30.74	286 / 286
thymus	100%	3238.51	653 / 653	100%	30.03	604 / 605
bladder	100%	3108.90	21 / 21	100%	26.01	503 / 504
prostate	100%	2710.55	245 / 245	100%	26.51	501 / 502
uterus	100%	3223.13	170 / 170	100%	26.88	458 / 459
ovary	100%	2803.59	180 / 180	100%	20.28	429 / 430
brain	100%	1849.71	2631 / 2642	100%	24.54	705 / 705
pancreas	100%	1730.20	328 / 328	99%	27.78	177 / 178
kidney	100%	2253.97	89 / 89	99%	26.76	892 / 901
liver	100%	2052.96	226 / 226	98%	18.41	397 / 406
adrenal gland	100%	3012.85	258 / 258	97%	18.94	222 / 230
skin	100%	4764.38	1809 / 1809	96%	25.19	453 / 472
adipose	100%	3397.43	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3256.81	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	33.77	29 / 29
muscle	100%	3812.50	803 / 803	0%	0	0 / 0
spleen	100%	3159.70	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	27.15	45 / 45
ureter	0%	0	0 / 0	100%	13.06	1 / 1
heart	97%	1715.20	834 / 861	0%	0	0 / 0
peripheral blood	96%	3277.12	892 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	93%	15.77	74 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0071168	Biological process	protein localization to chromatin
GO_0045875	Biological process	negative regulation of sister chromatid cohesion
GO_0051301	Biological process	cell division
GO_0008156	Biological process	negative regulation of DNA replication
GO_0000070	Biological process	mitotic sister chromatid segregation
GO_0035562	Biological process	negative regulation of chromatin binding
GO_0000775	Cellular component	chromosome, centromeric region
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005694	Cellular component	chromosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0072686	Cellular component	mitotic spindle
GO_0005737	Cellular component	cytoplasm
GO_0045171	Cellular component	intercellular bridge
GO_0005634	Cellular component	nucleus
GO_0140083	Molecular function	ATP-dependent protein-DNA unloader activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	WAPL
Protein name	WAPL cohesin release factor Wings apart-like homolog variant 1 (Wings apart-like homolog variant 12) (Wings apart-like homolog variant 2) (Wings apart-like homolog variant 3) (Wings apart-like homolog variant 5) (Wings apart-like homolog variant 6) (Wings apart-like homolog variant 9) Wings apart-like homolog variant 14 Wings apart-like homolog variant 17 Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) WAPAL protein Wings apart-like homolog variant 7 Wings apart-like homolog variant 11 Wings apart-like homolog variant 15 Wings apart-like homolog variant 4 Wings apart-like homolog variant 16 Wings apart-like homolog variant 13 Wings apart-like homolog variant 8
Synonyms	WAPAL FOE KIAA0261
Description	FUNCTION: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin . Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. .
Accessions	B3Y1X7 ENST00000372075.2 Q7Z5K2 Q8WVX6 B3Y1X4 B3Y1X6 F6QZY1 B2RTX8 B3Y1W5 B3Y1W8 B3Y1X2 ENST00000298767.10 [Q7Z5K2-1] B3Y1X8 B3Y1X5 B3Y1W2 B3Y1W9

WAPL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review