UBR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050862Biological processpositive regulation of T cell receptor signaling pathway
GO_0016567Biological processprotein ubiquitination
GO_0007283Biological processspermatogenesis
GO_0071596Biological processubiquitin-dependent protein catabolic process via the N-end rule pathway
GO_0007131Biological processreciprocal meiotic recombination
GO_0032007Biological processnegative regulation of TOR signaling
GO_0031507Biological processheterochromatin formation
GO_0007141Biological processmale meiosis I
GO_0010526Biological processretrotransposon silencing
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0007140Biological processmale meiotic nuclear division
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0071233Biological processcellular response to L-leucine
GO_0000151Cellular componentubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0070728Molecular functionL-leucine binding
GO_0008270Molecular functionzinc ion binding
GO_0141053Molecular functionhistone H2A ubiquitin ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBR2
Protein nameE3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (RING-type E3 ubiquitin transferase UBR2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II)
SynonymsC6orf133
KIAA0349
DescriptionFUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway . Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (By similarity). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth . Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity). Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis (By similarity). .

AccessionsENST00000372903.6 [Q8IWV8-2]
ENST00000372901.2 [Q8IWV8-4]
Q8IWV8
ENST00000372899.6 [Q8IWV8-1]