UBE2K report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032434Biological processregulation of proteasomal ubiquitin-dependent protein catabolic process
GO_1903265Biological processpositive regulation of tumor necrosis factor-mediated signaling pathway
GO_0000209Biological processprotein polyubiquitination
GO_0060340Biological processpositive regulation of type I interferon-mediated signaling pathway
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0010994Biological processfree ubiquitin chain polymerization
GO_0035458Biological processcellular response to interferon-beta
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0032433Cellular componentfilopodium tip
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0034450Molecular functionubiquitin-ubiquitin ligase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005524Molecular functionATP binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBE2K
Protein nameUbiquitin conjugating enzyme E2 K
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
E2 ubiquitin-conjugating enzyme (EC 2.3.2.23)
Alternative protein UBE2K
SynonymsLIG
HIP2
DescriptionFUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1. .

AccessionsENST00000510719.1
ENST00000503368.5 [P61086-2]
D6RFX1
ENST00000510934.5
ENST00000445950.2 [P61086-3]
ENST00000261427.10 [P61086-1]
D6RDM7
L8E874
P61086