UBE2H | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	33 studies	34% ± 15%	Explore
fibroblast	22 studies	30% ± 12%	Explore
smooth muscle cell	22 studies	26% ± 9%	Explore
ciliated cell	19 studies	44% ± 16%	Explore
astrocyte	18 studies	36% ± 16%	Explore
pericyte	14 studies	30% ± 12%	Explore
basal cell	14 studies	37% ± 19%	Explore
oligodendrocyte	13 studies	34% ± 11%	Explore
B cell	12 studies	24% ± 9%	Explore
epithelial cell	12 studies	45% ± 26%	Explore
macrophage	12 studies	32% ± 13%	Explore
microglial cell	12 studies	35% ± 10%	Explore
oligodendrocyte precursor cell	12 studies	39% ± 15%	Explore
GABAergic neuron	11 studies	45% ± 21%	Explore
glutamatergic neuron	11 studies	46% ± 23%	Explore
endothelial cell of lymphatic vessel	10 studies	31% ± 14%	Explore
type I pneumocyte	9 studies	34% ± 12%	Explore
adipocyte	9 studies	46% ± 12%	Explore
neuron	8 studies	41% ± 18%	Explore
endothelial cell of artery	8 studies	22% ± 7%	Explore
endothelial cell of vascular tree	8 studies	36% ± 19%	Explore
T cell	7 studies	23% ± 7%	Explore
natural killer cell	7 studies	23% ± 3%	Explore
type II pneumocyte	7 studies	32% ± 10%	Explore
myeloid cell	7 studies	28% ± 6%	Explore
club cell	7 studies	37% ± 12%	Explore
secretory cell	7 studies	34% ± 13%	Explore
monocyte	6 studies	30% ± 11%	Explore
CD4-positive, alpha-beta T cell	6 studies	21% ± 3%	Explore
abnormal cell	6 studies	30% ± 15%	Explore
interneuron	6 studies	55% ± 19%	Explore
retina horizontal cell	6 studies	22% ± 4%	Explore
retinal cone cell	6 studies	24% ± 6%	Explore
dendritic cell	6 studies	24% ± 8%	Explore
mast cell	6 studies	29% ± 11%	Explore
Mueller cell	6 studies	30% ± 7%	Explore
capillary endothelial cell	6 studies	27% ± 9%	Explore
erythrocyte	6 studies	40% ± 24%	Explore
CD8-positive, alpha-beta T cell	5 studies	20% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
retinal bipolar neuron	5 studies	20% ± 3%	Explore
retinal ganglion cell	5 studies	26% ± 8%	Explore
kidney loop of Henle epithelial cell	5 studies	29% ± 10%	Explore
plasma cell	5 studies	39% ± 12%	Explore
amacrine cell	5 studies	28% ± 5%	Explore
cardiac muscle cell	5 studies	54% ± 13%	Explore
mesothelial cell	5 studies	29% ± 8%	Explore
vein endothelial cell	5 studies	36% ± 26%	Explore
lymphocyte	5 studies	34% ± 13%	Explore
respiratory goblet cell	5 studies	41% ± 15%	Explore
connective tissue cell	5 studies	25% ± 9%	Explore
myofibroblast cell	5 studies	30% ± 13%	Explore
squamous epithelial cell	4 studies	56% ± 16%	Explore
classical monocyte	4 studies	26% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	20% ± 1%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
granule cell	4 studies	38% ± 6%	Explore
retinal pigment epithelial cell	4 studies	42% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	27% ± 12%	Explore
naive B cell	4 studies	16% ± 0%	Explore
hepatocyte	4 studies	56% ± 15%	Explore
luminal cell of prostate epithelium	4 studies	34% ± 7%	Explore
muscle cell	4 studies	36% ± 19%	Explore
goblet cell	4 studies	39% ± 33%	Explore
renal principal cell	4 studies	34% ± 10%	Explore
ionocyte	3 studies	29% ± 12%	Explore
mature NK T cell	3 studies	24% ± 9%	Explore
non-classical monocyte	3 studies	25% ± 7%	Explore
GABAergic interneuron	3 studies	41% ± 3%	Explore
glial cell	3 studies	26% ± 8%	Explore
progenitor cell	3 studies	27% ± 2%	Explore
placental villous trophoblast	3 studies	49% ± 23%	Explore
brush cell	3 studies	37% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	17% ± 1%	Explore
GABAergic amacrine cell	3 studies	31% ± 5%	Explore
OFF-bipolar cell	3 studies	26% ± 4%	Explore
ON-bipolar cell	3 studies	25% ± 4%	Explore
glycinergic amacrine cell	3 studies	32% ± 3%	Explore
retinal rod cell	3 studies	18% ± 2%	Explore
rod bipolar cell	3 studies	29% ± 6%	Explore
gamma-delta T cell	3 studies	27% ± 9%	Explore
regulatory T cell	3 studies	21% ± 2%	Explore
ependymal cell	3 studies	49% ± 9%	Explore
adventitial cell	3 studies	23% ± 9%	Explore
leukocyte	3 studies	27% ± 3%	Explore
alveolar macrophage	3 studies	34% ± 9%	Explore
Schwann cell	3 studies	26% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	36% ± 7%	Explore
renal alpha-intercalated cell	3 studies	28% ± 8%	Explore
mural cell	3 studies	40% ± 11%	Explore
mucus secreting cell	3 studies	46% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	40% ± 18%	Explore
lung	11 studies	31% ± 14%	Explore
eye	8 studies	27% ± 17%	Explore
heart	5 studies	33% ± 11%	Explore
placenta	4 studies	29% ± 13%	Explore
prostate	4 studies	27% ± 7%	Explore
intestine	4 studies	20% ± 2%	Explore
kidney	4 studies	31% ± 9%	Explore
peripheral blood	3 studies	25% ± 3%	Explore
uterus	3 studies	32% ± 19%	Explore
breast	3 studies	24% ± 6%	Explore
liver	3 studies	36% ± 16%	Explore
adipose	3 studies	46% ± 21%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9084.15	1445 / 1445	100%	84.27	183 / 183
ovary	100%	8511.31	180 / 180	100%	121.07	430 / 430
prostate	100%	7438.62	245 / 245	100%	91.16	502 / 502
breast	100%	9120.61	459 / 459	100%	125.34	1116 / 1118
brain	100%	7436.84	2640 / 2642	100%	133.46	704 / 705
kidney	100%	8290.22	89 / 89	100%	81.42	898 / 901
skin	100%	8114.31	1809 / 1809	100%	100.26	470 / 472
lung	100%	9689.87	578 / 578	100%	97.87	1150 / 1155
adrenal gland	100%	15932.15	258 / 258	100%	84.29	229 / 230
uterus	100%	9245.23	170 / 170	100%	88.92	457 / 459
pancreas	100%	6349.74	328 / 328	99%	96.11	177 / 178
bladder	100%	7247.10	21 / 21	99%	74.58	501 / 504
thymus	100%	8295.41	653 / 653	99%	94.70	601 / 605
stomach	100%	6507.06	359 / 359	99%	57.64	284 / 286
intestine	100%	8491.04	966 / 966	99%	61.35	522 / 527
liver	100%	3638.78	226 / 226	95%	45.12	387 / 406
adipose	100%	9131.57	1204 / 1204	0%	0	0 / 0
blood vessel	100%	13833.27	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	44.52	29 / 29
muscle	100%	10067.62	803 / 803	0%	0	0 / 0
spleen	100%	6246.99	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	56.85	1 / 1
peripheral blood	100%	8688.57	928 / 929	0%	0	0 / 0
heart	98%	7278.01	842 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	61.40	44 / 45
eye	0%	0	0 / 0	96%	54.64	77 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_0070979	Biological process	protein K11-linked ubiquitination
GO_0000209	Biological process	protein polyubiquitination
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0061631	Molecular function	ubiquitin conjugating enzyme activity
GO_0005515	Molecular function	protein binding
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	UBE2H
Protein name	Ubiquitin conjugating enzyme E2 H Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H) Uncharacterized protein UBE2H E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) Ubiquitin conjugating enzyme E2 H (Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast), isoform CRA_a)
Synonyms	hCG_18056 tcag7.352
Description	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex . In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination . Capable, in vitro, to ubiquitinate histone H2A . .
Accessions	A4D1L5 A0A3B3IU20 C9JZY6 ENST00000649897.1 ENST00000496698.5 ENST00000472396.5 ENST00000490974.1 P62256 C9JZG9 H7C4M9 ENST00000355621.8 [P62256-1] C9J8Q9 Q75MF5 ENST00000480245.5 ENST00000473814.6 [P62256-2]

UBE2H report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review