UBA2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
pericyte	38 studies	38% ± 12%	Explore
smooth muscle cell	24 studies	38% ± 12%	Explore
fibroblast	19 studies	25% ± 10%	Explore
B cell	18 studies	22% ± 5%	Explore
CD4-positive, alpha-beta T cell	18 studies	23% ± 6%	Explore
endothelial cell	18 studies	31% ± 12%	Explore
CD8-positive, alpha-beta T cell	17 studies	22% ± 6%	Explore
natural killer cell	14 studies	23% ± 8%	Explore
regulatory T cell	14 studies	20% ± 4%	Explore
T cell	12 studies	21% ± 6%	Explore
endothelial cell of lymphatic vessel	10 studies	23% ± 9%	Explore
gamma-delta T cell	10 studies	25% ± 14%	Explore
naive B cell	9 studies	21% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	21% ± 5%	Explore
memory B cell	9 studies	19% ± 2%	Explore
adipocyte	9 studies	32% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	21% ± 4%	Explore
myofibroblast cell	8 studies	31% ± 14%	Explore
basal cell	8 studies	28% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	20% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	21% ± 3%	Explore
mature NK T cell	7 studies	18% ± 2%	Explore
abnormal cell	7 studies	25% ± 9%	Explore
glutamatergic neuron	7 studies	41% ± 23%	Explore
mucosal invariant T cell	7 studies	21% ± 3%	Explore
epithelial cell	7 studies	37% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	21% ± 6%	Explore
astrocyte	7 studies	27% ± 9%	Explore
GABAergic neuron	7 studies	36% ± 19%	Explore
oligodendrocyte precursor cell	7 studies	27% ± 10%	Explore
connective tissue cell	6 studies	30% ± 9%	Explore
neuron	6 studies	32% ± 13%	Explore
microglial cell	6 studies	26% ± 5%	Explore
T follicular helper cell	6 studies	19% ± 4%	Explore
oligodendrocyte	6 studies	27% ± 6%	Explore
plasmacytoid dendritic cell	6 studies	26% ± 8%	Explore
hematopoietic precursor cell	5 studies	29% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 3%	Explore
progenitor cell	5 studies	18% ± 2%	Explore
pro-B cell	5 studies	26% ± 4%	Explore
macrophage	5 studies	25% ± 7%	Explore
dendritic cell	5 studies	32% ± 19%	Explore
interneuron	5 studies	39% ± 22%	Explore
erythroblast	4 studies	33% ± 17%	Explore
lymphocyte	4 studies	25% ± 4%	Explore
myeloid cell	4 studies	22% ± 6%	Explore
immature B cell	4 studies	22% ± 6%	Explore
retina horizontal cell	4 studies	25% ± 8%	Explore
ciliated cell	4 studies	28% ± 7%	Explore
muscle cell	4 studies	33% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	23% ± 6%	Explore
mast cell	4 studies	19% ± 6%	Explore
endothelial cell of vascular tree	4 studies	26% ± 9%	Explore
goblet cell	4 studies	26% ± 11%	Explore
mesothelial cell	4 studies	28% ± 13%	Explore
plasmablast	3 studies	50% ± 7%	Explore
classical monocyte	3 studies	24% ± 5%	Explore
conventional dendritic cell	3 studies	35% ± 12%	Explore
non-classical monocyte	3 studies	26% ± 7%	Explore
neural crest cell	3 studies	26% ± 4%	Explore
retinal bipolar neuron	3 studies	26% ± 6%	Explore
capillary endothelial cell	3 studies	18% ± 2%	Explore
precursor B cell	3 studies	26% ± 3%	Explore
rod bipolar cell	3 studies	18% ± 1%	Explore
germinal center B cell	3 studies	20% ± 5%	Explore
exhausted T cell	3 studies	19% ± 1%	Explore
innate lymphoid cell	3 studies	19% ± 3%	Explore
hematopoietic stem cell	3 studies	23% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	40% ± 19%	Explore
intestinal crypt stem cell	3 studies	22% ± 4%	Explore
leukocyte	3 studies	22% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	26% ± 12%	Explore
melanocyte	3 studies	41% ± 9%	Explore
transit amplifying cell	3 studies	40% ± 19%	Explore
T-helper 1 cell	3 studies	20% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	21% ± 6%	Explore
brain	11 studies	31% ± 17%	Explore
lung	7 studies	24% ± 6%	Explore
eye	5 studies	24% ± 11%	Explore
bone marrow	4 studies	18% ± 4%	Explore
intestine	4 studies	23% ± 9%	Explore
adipose	4 studies	19% ± 2%	Explore
kidney	3 studies	18% ± 3%	Explore
lymph node	3 studies	25% ± 7%	Explore
liver	3 studies	41% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4573.90	1445 / 1445	100%	88.89	183 / 183
breast	100%	8000.55	459 / 459	100%	89.65	1117 / 1118
lung	100%	5292.30	577 / 578	100%	100.34	1155 / 1155
uterus	100%	6166.95	170 / 170	100%	102.96	458 / 459
ovary	100%	5577.38	180 / 180	100%	80.78	429 / 430
brain	100%	4503.26	2633 / 2642	100%	89.63	705 / 705
stomach	100%	3612.83	359 / 359	100%	78.92	285 / 286
intestine	100%	4448.89	966 / 966	99%	80.66	524 / 527
bladder	100%	5412.86	21 / 21	99%	88.62	501 / 504
prostate	100%	4168.96	244 / 245	100%	62.44	501 / 502
thymus	100%	5204.85	652 / 653	99%	67.55	600 / 605
adrenal gland	100%	4066.48	258 / 258	98%	63.29	225 / 230
skin	100%	6185.28	1809 / 1809	98%	115.90	461 / 472
kidney	100%	3270.89	89 / 89	98%	56.58	880 / 901
pancreas	97%	2596.70	319 / 328	99%	62.94	176 / 178
liver	92%	1774.30	209 / 226	94%	37.71	382 / 406
adipose	100%	9643.24	1204 / 1204	0%	0	0 / 0
blood vessel	100%	11781.53	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	78.96	29 / 29
muscle	100%	6768.41	803 / 803	0%	0	0 / 0
spleen	100%	3733.49	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	89.77	45 / 45
ureter	0%	0	0 / 0	100%	34.16	1 / 1
heart	97%	2980.59	835 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	99.09	76 / 80
peripheral blood	54%	2779.80	498 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016925	Biological process	protein sumoylation
GO_0033235	Biological process	positive regulation of protein sumoylation
GO_0031510	Cellular component	SUMO activating enzyme complex
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0032183	Molecular function	SUMO binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0016740	Molecular function	transferase activity
GO_0044390	Molecular function	ubiquitin-like protein conjugating enzyme binding
GO_0005524	Molecular function	ATP binding
GO_0019948	Molecular function	SUMO activating enzyme activity
GO_0044388	Molecular function	small protein activating enzyme binding
GO_0005515	Molecular function	protein binding
GO_0000287	Molecular function	magnesium ion binding

IV. Literature review

[source]

Gene name	UBA2
Protein name	SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) Ubiquitin like modifier activating enzyme 2
Synonyms	SAE2 UBLE1B HRIHFB2115
Description	FUNCTION: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. .
Accessions	Q9UBT2 ENST00000590048.6 U3KQ93 K7ESK7 ENST00000246548.9 [Q9UBT2-1] ENST00000591016.1 ENST00000439527.6 [Q9UBT2-2] ENST00000586313.1 ENST00000607361.5 ENST00000592791.1 K7ES38 U3KQ55 K7EPL2

UBA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review