TRAF3IP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032481Biological processpositive regulation of type I interferon production
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0005741Cellular componentmitochondrial outer membrane
GO_0000139Cellular componentGolgi membrane
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0005739Cellular componentmitochondrion
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameTRAF3IP3
Protein nameTRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3)
TRAF3 interacting protein 3
SynonymsT3JAM
DescriptionFUNCTION: Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development . Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF . Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism . Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts . In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production . However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 . .

AccessionsENST00000400959.7
ENST00000478359.5 [Q9Y228-3]
E2QRE5
ENST00000487271.5
ENST00000367026.7 [Q9Y228-2]
H0YF09
ENST00000477431.1
ENST00000367025.8 [Q9Y228-1]
C9JBA0
ENST00000479796.5
C9JXB3
A0A0K2GUT3
C9J0C0
ENST00000471368.1
ENST00000367024.5 [Q9Y228-1]
ENST00000367023.5
Q9Y228
B1AJU2