TMC6 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	28 studies	24% ± 6%	Explore
CD8-positive, alpha-beta T cell	23 studies	23% ± 7%	Explore
CD4-positive, alpha-beta T cell	23 studies	23% ± 7%	Explore
B cell	22 studies	22% ± 5%	Explore
T cell	21 studies	22% ± 7%	Explore
regulatory T cell	19 studies	25% ± 5%	Explore
memory B cell	17 studies	21% ± 4%	Explore
non-classical monocyte	15 studies	29% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	28% ± 8%	Explore
gamma-delta T cell	13 studies	27% ± 8%	Explore
naive B cell	13 studies	20% ± 5%	Explore
mature NK T cell	12 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	29% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	24% ± 4%	Explore
oligodendrocyte	11 studies	25% ± 8%	Explore
mucosal invariant T cell	11 studies	28% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	24% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	26% ± 7%	Explore
macrophage	10 studies	25% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	27% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	27% ± 11%	Explore
T follicular helper cell	7 studies	23% ± 6%	Explore
epithelial cell	5 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	23% ± 6%	Explore
plasmablast	4 studies	44% ± 20%	Explore
myeloid cell	4 studies	21% ± 5%	Explore
immature B cell	4 studies	19% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	29% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	22% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	34% ± 9%	Explore
alveolar macrophage	4 studies	25% ± 9%	Explore
plasma cell	3 studies	35% ± 11%	Explore
classical monocyte	3 studies	32% ± 7%	Explore
conventional dendritic cell	3 studies	30% ± 10%	Explore
exhausted T cell	3 studies	35% ± 11%	Explore
monocyte	3 studies	23% ± 2%	Explore
lymphocyte	3 studies	28% ± 3%	Explore
endothelial cell	3 studies	18% ± 4%	Explore
leukocyte	3 studies	18% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 5%	Explore
basal cell	3 studies	20% ± 2%	Explore
T-helper 1 cell	3 studies	23% ± 6%	Explore
innate lymphoid cell	3 studies	26% ± 5%	Explore
double negative thymocyte	3 studies	26% ± 5%	Explore
abnormal cell	3 studies	23% ± 6%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	24% ± 5%	Explore
lung	4 studies	18% ± 1%	Explore
brain	4 studies	22% ± 4%	Explore
liver	3 studies	23% ± 9%	Explore
lymph node	3 studies	20% ± 1%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	6328.68	578 / 578	99%	33.39	1147 / 1155
breast	100%	3763.88	459 / 459	96%	19.14	1077 / 1118
prostate	98%	3053.34	241 / 245	97%	17.98	485 / 502
thymus	99%	2119.56	646 / 653	96%	38.19	579 / 605
esophagus	94%	1859.02	1364 / 1445	100%	22.28	183 / 183
intestine	95%	3529.14	921 / 966	99%	26.41	520 / 527
stomach	96%	1455.33	345 / 359	97%	22.55	278 / 286
bladder	95%	2093.67	20 / 21	98%	34.36	493 / 504
uterus	94%	1310.34	160 / 170	96%	25.50	441 / 459
pancreas	90%	1234.05	296 / 328	95%	28.28	169 / 178
brain	82%	2208.17	2169 / 2642	93%	15.21	659 / 705
kidney	97%	2307.99	86 / 89	78%	9.84	704 / 901
skin	72%	1622.73	1306 / 1809	94%	33.98	445 / 472
ovary	31%	317.71	55 / 180	97%	19.08	415 / 430
lymph node	0%	0	0 / 0	100%	62.87	29 / 29
spleen	100%	15798.63	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	17.33	1 / 1
adipose	100%	3518.18	1203 / 1204	0%	0	0 / 0
peripheral blood	100%	9500.45	928 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	99%	33.87	79 / 80
heart	98%	2285.23	843 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	32.69	44 / 45
adrenal gland	80%	835.21	207 / 258	11%	0.82	25 / 230
liver	49%	525.24	111 / 226	39%	7.36	157 / 406
blood vessel	45%	686.25	606 / 1335	0%	0	0 / 0
muscle	6%	51.24	50 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0