TLK1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	24 studies	27% ± 9%	Explore
endothelial cell	20 studies	31% ± 13%	Explore
CD4-positive, alpha-beta T cell	19 studies	24% ± 6%	Explore
regulatory T cell	19 studies	29% ± 6%	Explore
memory B cell	17 studies	21% ± 4%	Explore
naive B cell	15 studies	22% ± 5%	Explore
astrocyte	15 studies	42% ± 18%	Explore
T cell	14 studies	22% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	12 studies	19% ± 3%	Explore
macrophage	12 studies	30% ± 12%	Explore
natural killer cell	11 studies	20% ± 3%	Explore
microglial cell	11 studies	29% ± 10%	Explore
platelet	10 studies	34% ± 11%	Explore
glutamatergic neuron	10 studies	51% ± 24%	Explore
endothelial cell of lymphatic vessel	9 studies	28% ± 11%	Explore
GABAergic neuron	9 studies	48% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	19% ± 3%	Explore
oligodendrocyte precursor cell	9 studies	31% ± 9%	Explore
epithelial cell	9 studies	39% ± 16%	Explore
basal cell	9 studies	30% ± 15%	Explore
fibroblast	9 studies	24% ± 10%	Explore
adipocyte	9 studies	25% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	21% ± 5%	Explore
mucosal invariant T cell	8 studies	20% ± 3%	Explore
oligodendrocyte	8 studies	28% ± 15%	Explore
mast cell	7 studies	26% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	23% ± 5%	Explore
retinal cone cell	7 studies	37% ± 10%	Explore
ciliated cell	7 studies	30% ± 9%	Explore
T follicular helper cell	7 studies	27% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	20% ± 2%	Explore
smooth muscle cell	7 studies	18% ± 2%	Explore
gamma-delta T cell	7 studies	21% ± 9%	Explore
plasmacytoid dendritic cell	7 studies	22% ± 7%	Explore
plasma cell	6 studies	36% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	18% ± 3%	Explore
interneuron	6 studies	47% ± 23%	Explore
myeloid cell	6 studies	25% ± 4%	Explore
club cell	6 studies	26% ± 10%	Explore
retinal rod cell	6 studies	34% ± 12%	Explore
dendritic cell	6 studies	27% ± 9%	Explore
type I pneumocyte	6 studies	22% ± 7%	Explore
leukocyte	5 studies	24% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	21% ± 5%	Explore
neuron	5 studies	42% ± 21%	Explore
monocyte	5 studies	31% ± 7%	Explore
goblet cell	5 studies	32% ± 21%	Explore
type II pneumocyte	5 studies	24% ± 6%	Explore
hematopoietic precursor cell	4 studies	31% ± 12%	Explore
mature NK T cell	4 studies	24% ± 8%	Explore
precursor B cell	4 studies	20% ± 2%	Explore
cardiac muscle cell	4 studies	23% ± 1%	Explore
lymphocyte	4 studies	39% ± 11%	Explore
amacrine cell	4 studies	21% ± 9%	Explore
hematopoietic stem cell	4 studies	30% ± 17%	Explore
respiratory goblet cell	4 studies	34% ± 11%	Explore
pericyte	4 studies	22% ± 6%	Explore
classical monocyte	3 studies	21% ± 4%	Explore
non-classical monocyte	3 studies	22% ± 7%	Explore
plasmablast	3 studies	36% ± 8%	Explore
GABAergic interneuron	3 studies	36% ± 2%	Explore
retinal ganglion cell	3 studies	30% ± 6%	Explore
retina horizontal cell	3 studies	23% ± 10%	Explore
retinal bipolar neuron	3 studies	19% ± 0%	Explore
Mueller cell	3 studies	30% ± 8%	Explore
glycinergic amacrine cell	3 studies	18% ± 2%	Explore
CD4-positive helper T cell	3 studies	22% ± 3%	Explore
innate lymphoid cell	3 studies	17% ± 0%	Explore
hepatocyte	3 studies	50% ± 13%	Explore
retinal pigment epithelial cell	3 studies	36% ± 22%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	27% ± 9%	Explore
abnormal cell	3 studies	45% ± 16%	Explore
connective tissue cell	3 studies	19% ± 1%	Explore
ependymal cell	3 studies	41% ± 13%	Explore
megakaryocyte	3 studies	48% ± 13%	Explore
alveolar macrophage	3 studies	39% ± 10%	Explore
transit amplifying cell	3 studies	36% ± 28%	Explore
brush cell	3 studies	30% ± 10%	Explore
T-helper 17 cell	3 studies	20% ± 2%	Explore
granule cell	3 studies	24% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	19% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	24% ± 10%	Explore
mucus secreting cell	3 studies	30% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	37% ± 20%	Explore
lung	9 studies	25% ± 10%	Explore
peripheral blood	8 studies	22% ± 6%	Explore
eye	7 studies	32% ± 13%	Explore
heart	4 studies	19% ± 3%	Explore
liver	4 studies	36% ± 18%	Explore
adipose	4 studies	25% ± 6%	Explore
intestine	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3107.05	1445 / 1445	100%	25.04	183 / 183
prostate	100%	3272.46	245 / 245	100%	37.07	502 / 502
brain	100%	3017.60	2640 / 2642	100%	22.07	705 / 705
uterus	100%	3079.68	170 / 170	100%	19.48	458 / 459
ovary	100%	3363.07	180 / 180	100%	16.56	429 / 430
breast	100%	2962.69	459 / 459	100%	31.12	1115 / 1118
adrenal gland	100%	3215.04	258 / 258	100%	22.97	229 / 230
thymus	100%	3051.92	653 / 653	100%	24.00	602 / 605
lung	99%	2392.59	575 / 578	100%	24.66	1155 / 1155
pancreas	100%	1760.75	328 / 328	99%	19.94	177 / 178
intestine	100%	3960.68	966 / 966	99%	19.85	523 / 527
kidney	100%	2437.78	89 / 89	99%	18.15	893 / 901
bladder	100%	3387.81	21 / 21	99%	18.20	499 / 504
stomach	100%	2764.48	359 / 359	99%	19.56	282 / 286
liver	100%	1950.71	226 / 226	98%	14.83	399 / 406
skin	100%	2865.88	1809 / 1809	93%	17.64	439 / 472
adipose	100%	2628.35	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3009.57	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	23.71	29 / 29
spleen	100%	3214.53	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.98	45 / 45
ureter	0%	0	0 / 0	100%	9.40	1 / 1
muscle	99%	1314.52	793 / 803	0%	0	0 / 0
heart	94%	1327.50	812 / 861	0%	0	0 / 0
peripheral blood	89%	3606.26	830 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	73%	8.85	58 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0006974	Biological process	DNA damage response
GO_0006886	Biological process	intracellular protein transport
GO_0035556	Biological process	intracellular signal transduction
GO_0006468	Biological process	protein phosphorylation
GO_1902275	Biological process	regulation of chromatin organization
GO_0007059	Biological process	chromosome segregation
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005515	Molecular function	protein binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	TLK1
Protein name	Tousled like kinase 1 (Tousled-like kinase 1, isoform CRA_b) (cDNA FLJ34656 fis, clone KIDNE2018352, highly similar to Serine/threonine-protein kinase tousled-like 1) Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) Uncharacterized protein TLK1 Tousled like kinase 1
Synonyms	KIAA0137 hCG_15833
Description	FUNCTION: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. .
Accessions	F8W7X8 ENST00000453628.1 Q53TE4 ENST00000521943.5 [Q9UKI8-5] C9JWT6 ENST00000431350.7 [Q9UKI8-1] B3KRP1 Q53TF9 ENST00000359766.7 ENST00000409443.6 ENST00000360843.7 [Q9UKI8-2] Q9UKI8 ENST00000434911.6 [Q9UKI8-4]

TLK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review