TEX264 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	17 studies	21% ± 5%	Explore
CD8-positive, alpha-beta T cell	14 studies	24% ± 5%	Explore
CD4-positive, alpha-beta T cell	13 studies	21% ± 4%	Explore
regulatory T cell	13 studies	23% ± 5%	Explore
endothelial cell	10 studies	26% ± 8%	Explore
endothelial cell of lymphatic vessel	9 studies	23% ± 7%	Explore
T cell	9 studies	20% ± 5%	Explore
ciliated cell	9 studies	28% ± 12%	Explore
non-classical monocyte	9 studies	25% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	23% ± 4%	Explore
basal cell	7 studies	29% ± 15%	Explore
mature NK T cell	7 studies	19% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	21% ± 1%	Explore
fibroblast	7 studies	22% ± 7%	Explore
B cell	7 studies	18% ± 3%	Explore
epithelial cell	7 studies	37% ± 15%	Explore
plasmacytoid dendritic cell	7 studies	22% ± 6%	Explore
gamma-delta T cell	7 studies	23% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	23% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	21% ± 2%	Explore
memory B cell	6 studies	18% ± 2%	Explore
plasma cell	5 studies	24% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	25% ± 5%	Explore
classical monocyte	5 studies	25% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	24% ± 5%	Explore
macrophage	5 studies	25% ± 7%	Explore
mucosal invariant T cell	5 studies	20% ± 4%	Explore
secretory cell	4 studies	27% ± 12%	Explore
conventional dendritic cell	4 studies	34% ± 13%	Explore
exhausted T cell	4 studies	28% ± 8%	Explore
epithelial cell of proximal tubule	4 studies	17% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	31% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	29% ± 7%	Explore
plasmablast	3 studies	44% ± 10%	Explore
hematopoietic precursor cell	3 studies	24% ± 3%	Explore
kidney loop of Henle epithelial cell	3 studies	28% ± 9%	Explore
retinal cone cell	3 studies	32% ± 6%	Explore
T follicular helper cell	3 studies	18% ± 3%	Explore
endothelial cell of vascular tree	3 studies	17% ± 1%	Explore
type I pneumocyte	3 studies	26% ± 8%	Explore
dendritic cell	3 studies	39% ± 9%	Explore
goblet cell	3 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	21% ± 6%	Explore
double negative thymocyte	3 studies	24% ± 5%	Explore
naive B cell	3 studies	16% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	21% ± 4%	Explore
kidney	4 studies	20% ± 2%	Explore
brain	4 studies	17% ± 2%	Explore
lung	3 studies	32% ± 12%	Explore
liver	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	2141.46	226 / 226	100%	38.18	406 / 406
ovary	100%	1956.25	180 / 180	100%	32.31	430 / 430
pancreas	100%	1557.04	328 / 328	100%	35.43	178 / 178
skin	100%	3670.82	1809 / 1809	100%	49.78	472 / 472
thymus	100%	3211.47	653 / 653	100%	47.40	605 / 605
prostate	100%	3036.76	245 / 245	100%	65.35	501 / 502
uterus	100%	2185.49	170 / 170	100%	33.76	458 / 459
kidney	100%	3742.17	89 / 89	100%	46.41	899 / 901
brain	100%	1594.16	2635 / 2642	100%	34.50	705 / 705
intestine	100%	2446.24	966 / 966	100%	39.10	525 / 527
adrenal gland	100%	4382.33	258 / 258	100%	38.24	229 / 230
stomach	100%	2300.03	359 / 359	99%	31.99	284 / 286
breast	100%	2407.08	459 / 459	99%	40.55	1107 / 1118
bladder	100%	2326.43	21 / 21	99%	40.06	499 / 504
lung	99%	1915.74	574 / 578	100%	27.43	1150 / 1155
esophagus	100%	2032.57	1445 / 1445	98%	16.19	180 / 183
adipose	100%	2173.07	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	55.32	80 / 80
lymph node	0%	0	0 / 0	100%	41.56	29 / 29
spleen	100%	2848.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	24.80	45 / 45
ureter	0%	0	0 / 0	100%	63.61	1 / 1
blood vessel	100%	1470.76	1330 / 1335	0%	0	0 / 0
muscle	99%	1226.94	791 / 803	0%	0	0 / 0
heart	98%	1583.08	846 / 861	0%	0	0 / 0
peripheral blood	96%	1651.29	896 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0061709	Biological process	reticulophagy
GO_0106300	Biological process	protein-DNA covalent cross-linking repair
GO_0005657	Cellular component	replication fork
GO_0000421	Cellular component	autophagosome membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0005576	Cellular component	extracellular region
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005634	Cellular component	nucleus
GO_0038023	Molecular function	signaling receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TEX264
Protein name	Testis expressed 264, ER-phagy receptor Testis-expressed protein 264 (Putative secreted protein Zsig11)
Synonyms	ZSIG11 UNQ337/PRO536
Description	FUNCTION: Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover . The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins . Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure . Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN . .
Accessions	C9JXQ7 ENST00000415259.5 ENST00000611400.4 C9J7N0 ENST00000341333.10 ENST00000457573.5 C9JHH5 ENST00000416589.5 ENST00000419358.5 Q9Y6I9 C9JL43 ENST00000395057.5 A0A087WTU3 ENST00000444233.1 C9JUC3 ENST00000457927.5 ENST00000412249.5 ENST00000425781.5 ENST00000614067.4

TEX264 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review